HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Midodrine Hydrochloride
MIDODRINE · GUTRON · ST-1085 · AMATINE · HIPERTAN · METLIGINE · PROAMATINE · MIDODRINE HCL
Identifikatoren & physikalische Daten
| CAS No. | 3092-17-9 |
|---|---|
| Summenformel | C12H19ClN2O4 |
| Durchschnittliche Molmasse | 290,74 g/mol |
| Monoisotopische Masse | 290,1033348 g/mol |
| SMILES | COc1ccc(OC)c(C(O)CNC(=O)CN)c1.Cl |
| InChIKey | MGCQZNBCJBRZDT-UHFFFAOYSA-N |
| PubChem CID | 18340 |
| ChEMBL | CHEMBL1200461 |
| ChEBI | CHEBI:31847 |
| EC No. | 256-148-3 |
| DTXSID | DTXSID1047493 |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 93,8 |
|---|---|
| H-Brücken-Donoren | 4 |
| H-Brücken-Akzeptoren | 5 |
| Frei drehbare Bindungen | 6 |
| Schwere Atome | 19 |
| Formalladung | 0 |
| Komplexität | 262 |
| Human Drugs | FDA approved drugs -> Active ingredient |
| Collision Cross Section | 154 Ų [M+H-H2O]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards] |
| Schmelzpunkt | 192-193°C |
| Lagerbedingungen | -20°C Freezer |
| Hauptanwendungen | forensics and toxicologypharmaceutical (small molecule)veterinary |
| InChI | InChI=1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16)1H |
| InChIKey | MGCQZNBCJBRZDT-UHFFFAOYSA-N |
| SMILES | C1(C(O)CNC(=O)CN)C=C(C=CC=1OC)OC.Cl |
| CAS Datenbank | 3092-17-9(CAS DataBase Reference) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH301 (97.6%): Toxic if swallowed [Danger Acute toxicity, oral]P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 41 reports by companies from 2 notifications to the ECHA C&L Inventory.H301 (66.7%): Toxic if swallowed [Danger Acute toxicity, oral] |
|---|---|
| Hazard Classes and Categories | Acute Tox. 3 (66.7%)Acute Tox. 3 (97.6%) |
| Drug Induced Liver Injury | Drug Induced Liver Injury Rank (DILIrank 2.0)Midodrine hydrochloridevNo-DILI-concernNo matchDOI:10.1016/j.drudis.2016.02.015 |
| Wassergefährdungsklasse (WGK) | 3 |
| UN-Transportnummer | UN 2811 6.1/PG 3 |
| Zollcode | 29242990 |
| RTECS-Nr. | AB4343000 |
| R-Sätze (R) | 25 |
| Gefahrensymbole | T |
| Sicherheitshinweise (S) | 45 |
| Lagerklasse | 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects |
| Gefahrenklasse | Acute Tox. 3 Oral |
Anwendungen & Verwendung
Verwenden
A phenylalkanolamine derivative which has been found to be effective in treating hypertensive conditions due to their long lasting blood pressure increasing effects