HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Dodecyloxiran
2-Dodecyloxirane · dodecyl-oxiran · dodecyl-Oxirane · 2-lauryloxirane · n-dodecyloxirane · EPOXY TETRADECANE · Oxirane, dodecyl- · Oxirane, 2-dodecyl-
Identifikatoren & physikalische Daten
| CAS No. | 3234-28-4 |
|---|---|
| Summenformel | C14H28O |
| Durchschnittliche Molmasse | 212,37 g/mol |
| Monoisotopische Masse | 212,21401551 g/mol |
| SMILES | CCCCCCCCCCCCC1CO1 |
| InChIKey | IOHJQSFEAYDZGF-UHFFFAOYSA-N |
| PubChem CID | 18604 |
| ChEMBL | CHEMBL1598368 |
| EC No. | 221-781-6 |
| DTXSID | DTXSID9025249 |
| Lokaler Name | Dodecyloxiran |
Chemische & physikalische Eigenschaften
| XLogP | 6,3 |
|---|---|
| Polarare Oberfläche (TPSA) | 12,5 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 1 |
| Frei drehbare Bindungen | 11 |
| Schwere Atome | 15 |
| Formalladung | 0 |
| Komplexität | 133 |
| Dichte | 0.847 (NTP, 1992) - Less dense than waterwill float0.845 g/mL at 25 °C (lit.) |
| Löslichkeit | less than 1 mg/mL at 68 °F (NTP, 1992)130μg/L at 20℃ |
| Flammpunkt | greater than 235 °F (NTP, 1992)>110°C |
| Siedepunkt | 203 to 205 °F at 0.4 mmHg (NTP, 1992)95-96 °C/0.4 mmHg (lit.) |
| Schmelzpunkt | less than 68 °F (NTP, 1992)185-186 °C (decomp) |
| Physical Description | 1,2-epoxytetradecane is a clear colorless mobile liquid with an ether-like odor. (NTP, 1992) |
| Dampfdruck | 0.176Pa at 25℃ |
| Brechungsindex | 1.4408 |
| Aggregatzustand | liquid |
| Wichte | 0.845 |
| BRN | 107525 |
| InChI | InChI=1S/C14H28O/c1-2-3-4-5-6-7-8-9-10-11-12-14-13-15-14/h14H,2-13H2,1H3 |
| InChIKey | IOHJQSFEAYDZGF-UHFFFAOYSA-N |
| SMILES | O1CC1CCCCCCCCCCCC |
| LogP (Verteilungskoeffizient) | 5.77 at 25℃ |
| CAS Datenbank | 3234-28-4(CAS DataBase Reference) |
| EPA chemische Informationen | 1,2-Epoxytetradecane (3234-28-4) |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 2.9% (5 of 175) of reports.WarningH315 (97.1%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (26.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H335 (24%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]H400 (70.3%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]H410 (70.3%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]P261, P264, P264+P265, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 175 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Reported as not meeting GHS hazard criteria per 5 of 175 reports by companies.There are 9 notifications provided by 170 of 175 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| Regulatorische Informationen | Chemical: Oxirane, dodecyl-Oxirane, 2-dodecyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Oxirane, 2-dodecyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 15-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/11734Oxirane, dodecyl-: Does not have an individual approval but may be used under an appropriate group standard |
| Weitere Sicherheitsinformationen | IMAP assessments - Long-chain alkyl oxiranes: Human health tier II assessment |
| Brandgefahren | This chemical is probably combustible. (NTP, 1992) |
| Gesundheitsgefahren | ACUTE/CHRONIC HAZARDS: This compound is a local irritant. (NTP, 1992) |
| Reaktive Gruppe | EpoxidesPolymerizable Compounds |
| Reactivity Alerts | Polymerizable |
| Reactivity Profile | 1,2-EPOXYTETRADECANE, an epoxide, is incompatible with strong acids, caustics, and peroxides. (NTP, 1992). Epoxides are highly reactive. They polymerize in the presence of catalysts or when heated. These polymerization reactions can be violent. Compounds in this group react with acids, bases, and oxidizing and reducing agents. They react, possibly violently with water in the presence of acid and other catalysts. |
| Air and Water Reactions | This chemical is sensitive to exposure to moisture. Insoluble in water. |
| Hazard Classes and Categories | Skin Irrit. 2 (97.1%)Eye Irrit. 2 (26.9%)STOT SE 3 (24%)Aquatic Acute 1 (70.3%)Aquatic Chronic 1 (70.3%)Skin irritation - category 2Skin sensitisation - category 1 |
| Brandbekämpfung | Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992) |
| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.INHALATION: IMMEDIATELY leave the contaminated areatake deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be usedif not available, use a level of protection greater than or equal to that advised under Protective Clothing.INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992) |
| Freisetung ohne Brand | SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.STORAGE PRECAUTIONS: You should store this material under freezer conditions. (NTP, 1992) |
| Personal Protective Equipment (PPE) | RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992) |
| Wassergefährdungsklasse (WGK) | 1 |
| TSCA-Inventar-Status | TSCA listed |
| Zollcode | 2910.90.9100 |
| R-Sätze (R) | 36/38-36/37/38 |
| Gefahrensymbole | Xi |
| Sicherheitshinweise (S) | 26-36-37/39 |
| Lagerklasse | 10 - Combustible liquids |
| Gefahrenklasse | Aquatic Acute 1Aquatic Chronic 1Skin Irrit. 2 |
Anwendungen & Verwendung
Verwenden
1,2-Epoxytetradecane is used in the preparation of polymeric prodrugs used in treatments of cancer.