4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride
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Grundinformationen
- CAS
30827-99-7- Standard-SMILES
Cl.NCCc1ccc(S(=O)(=O)F)cc1- InChIKey
WRDABNWSWOHGMS-UHFFFAOYSA-N- Summenformel
- C8H11ClFNO2S
- Durchschnittliche Molmasse
- 239,699 g/mol
- Monoisotopische Masse
- 239,01830549
Namen und Bezeichner
- Bevorzugter Name
- 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride
- IUPAC
- 4-(2-Aminoethyl)benzene-1-sulfonyl fluoride--hydrogen chloride (1/1)
- Englischer Name
- 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
- Summenformel
- C8H11ClFNO2S
- Molmasse
- 239.69
Namen und Synonyme
AEBSF4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE HYDROCHLORIDEAEBSF HCLAEBSF HYDROCHLORIDECS-2583AEBSF HCIA8456-25MGPEFABLOC SCPEFABLOC(R) SCAEBSF Solution
Datenbank-Bezeichner
- CAS
30827-99-7- PubChem CID
- 186136
- DTXSID
DTXSID60184830- ChEMBL
CHEMBL1256178- ChEBI
CHEBI:233276- UNII
- DHA6VL95HL
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 175 · 175-177 °C
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- 2 O: · H2O: soluble50mg/mL (stable for up to six months if stored refrigerated at a pH of less than 7. If a pH of greater than 7 is required, pH adjustment should be made just prior to use.)
- Aggregatzustand
- Powder
- Farbe
- White
- PH
- 3 · pH3.0~5.0 (10g/L, 25℃)
- Biologische Quelle
- synthetic (organic)
- Wasserlöslichkeit
- 10 g/L · 10 g/L (20 ºC)
- BRN
- 7604627 · 7604627
- Stabilität
- 1 year · Stable for 1 year from date of purchase as supplied. Solutions at pH <7 are stable for up to 6 months if stored in the refrigerator
- InChI
- InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
- InChIKey
- WRDABNWSWOHGMS-UHFFFAOYSA-N
- SMILES
- S(C1C=CC(CCN)=CC=1)(=O)(=O)F.Cl
- CAS Datenbank
- 30827 · 30827-99-7(CAS DataBase Reference)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- ridadr
- UN 3261
- hs_code
- 29214990
- risk_code
- 34-36/37/38
- hazard_code
- C,Xi
- hazard_note
- Corrosive
- safety_code
- 45-36/37/39-26-36
- hazard_class
- 8
- packing_group
- II
- Speicherklasse
- 12 - Non Combustible Liquids
- Hazard Classifications
- Eye Irrit. 2Skin Irrit. 2
Chemie und Industrie
Anwendungen
BeschreibungAEBSF is a water soluble, irreversible, broad spectrum inhibitor of serine proteases, including trypsin, chymotrypsin, plasmin, thrombin, and kallikreins. AEBSF can also prevent the activation of the ROS generator, NADPH oxidase. At 10-50 μg, AEBSF can attenuate airway inflammation in a mouse model of airway allergy. AEBSF maintains stability in slightly acidic aqueous solutions and serves as a nontoxic alternative to the organophosphate inhibitors, PMSF and DFP.
VerwendenAEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.
Anbieter100 Anbieter
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
爱斯特（成都）生物制药股份有限公司+86-28-85122536 85324413 · [email protected]
上海如吉生物科技发展有限公司+86-21-65211385-8001 36031160 · [email protected]
四川星优天下医药科技有限公司18328380615 · [email protected]
Syntechem Co.,Ltd[email protected]
上海迈瑞尔生化科技有限公司4006356688 18621169109 · [email protected]
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