Cupric nitrate

2.32 at 68 °F (USCG, 1999) - Denser than water; will sink

2.05 @25 °C

137.8 g/100 cc water @ 0 °C, 1270 g/100 cc water @ 100 °C, 100 g/100 cc alcohol @ 12.5 °C, very slightly sol in liq ammonia /Cupric nitrate trihydrate/

243.7 g/100 cc water @ 0 °C, sol in all proportions in hot water, sol in alcohol /Cupric nitrate hexahydrate/

Sol in water, ethyl acetate, dioxane

238.1 °F (USCG, 1999)

255-256 °C

255 °C

FCS -> FDA Cumulative Estimated Daily Intake (CEDI)

FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR

Obtained as a trihydrate and as a hexahydrate. Both are blue crystalline solids. Used in medicine, as an insecticide, in chemical analysis, in making light sensitive papers. Toxic oxides of nitrogen are produced in fires involving this material.

Liquid; Large Crystals; Liquid

Blue-green deliquescent solid; Soluble in water; [Merck Index] Blue deliquescent crystals; Soluble in water; [MSDSonline]

Sublimes @ 150-225 °C

FP: 238.1 °F= 114.5 °C= 387 deg K /Cupric nitrate trihydrate/

Blue, deliquescent, rhombic plates; practically insoluble in ethyl acetate; pH of 0.2 M aqueous solution 4.0, melting point 114.5 °C, MW 241.60, density 2.05; BP 170, decomposes /Cupric nitrate trihydrate/

Blue, deliquescent, prismatic crystals, loses 3 waters at 26.4 °C, density 2.07, freely soluble in water, sol in alc /Cupric nitrate hexahydrate/

Dissolves in and reacts vigorously with ether

Decomposition begins around 80 °C upon formation of the basic salt; at temperatures of 180 °C the oxide is produced.

This chemical does not meet GHS hazard criteria for 1.6% (21 of 1286) of reports.

Danger

H270 (13.7%): May cause or intensify fire; oxidizer [Danger Oxidizing gases]

P210, P220, P244, P260, P264, P264+P265, P270, P273, P280, P301+P316, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P321, P330, P332+P317, P337+P317, P362+P364, P363, P370+P376, P370+P378, P391, P403, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 1286 reports by companies from 43 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

This chemical does not meet GHS hazard criteria for 48.6% (36 of 74) of reports.

Chemical: Nitric acid, copper(2+) salt

Nitric acid, copper(2+) salt (2:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Nitric acid, copper(2+) salt (2:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 22-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/14299

Nitric acid, copper(2+) salt: HSNO Approval: HSR001323 Approved with controls

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

It is noncombustible.

Mixtures with wood, paper, & other combustibles may catch fire. /Cupric nitrate trihydrate/

Inhalation causes irritation of throat and lungs. Ingestion of large amounts causes violent vomiting and purging, intense pain, collapse, coma, convulsions, and paralysis. Solutions irritate eyes; contact with solid causes severe eye surface injury and skin irritation. (USCG, 1999)

An oxidizer which may violently combust or explode on contact with organic materials; [Hawley] A skin, eye, and respiratory tract irritant; May cause serious damage to eyes; [HSDB] Contact with solid causes eye burns and skin irritation; [CHRIS] A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause chemical pneumonitis and pulmonary edema; May cause skin sensitization; [MSDSonline] See NITRATES and NITRITES. See Copper.

Mixtures of CUPRIC NITRATE with alkyl esters may explode, owing to the formation of alkyl nitrates. Mixtures with phosphorus, tin(II) chloride or other reducing agents may react explosively [Bretherick, 1979 p. 108-109]. A finely divided mixture of potassium ferrocyanide and cupric nitrate exploded when dried at 220 °C [Chem. Abst. 77:1343 (1972)]. Noncombustible, but it will accelerate the burning of combustible materials. If large quantities of the material are involved in a fire or the material is finely divided, an explosion may result. Prolonged exposure to fire or heat may result in an explosion.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.4 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Evacuation: If fire becomes uncontrollable consider evacuation of one-half (1/2) mile radius. /Cupric nitrate; Cupric nitrate solution/

If material on fire or involved in fire: Flood with water. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. /Cupric nitrate; Cupric nitrate solution/

Environmental consideration--land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.

Environmental consideration--land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder. Neutralize with agricultural lime (CaO), crushed limestone (CaCo3) or sodium bicarbonate (NaHCO3). /Cupric nitrate solution/

Environmental consideration--water spill: Neutralize with agricultural lime (CaO), crushed limestone (CaCO3), or sodium bicarbonate (NaHCO3). Adjust pH to neutral (pH= 7). Use Mechanical dredges or lifts to remove immobilized masses of pollutants & precipitates. /Cupric nitrate; Cupric nitrate solution/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

If material not on fire & not involved in fire: Keep sparks, flames, & other sources of ignition away. Keep material out of water sources & sewers. /Cupric nitrate; Cupric nitrate solution/

Personnel protection: ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap & water. ... /Cupric nitrate; Cupric nitrate solution/

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

1.0 [mg/m3], as Cu

8 hr Time Weighted Avg (TWA): 1 mg/cu m /Copper dusts and mists, as Cu/

Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded. /Copper dusts and mists, as Cu/

Methemoglobinemia can be treated with supplemental oxygen and methylene blue 1% solution administered intravenously slowly over five minutes followed by IV flush with normal saline. Methylene blue restores the iron in hemoglobin to its normal (reduced) oxygen-carrying state. (L1613)

People must absorb small amounts of copper every day because copper is essential for good health, however, high levels of copper can be harmful. Very-high doses of copper can cause damage to your liver and kidneys, and can even cause death. Copper may induce allergic responses in sensitive individuals. Nitrate and nitrite poisoning causes methemoglobinemia. Nitrites may cause pregnancy complications and developmental effects. They may also be carcinogenic. (L1137, L278, L279)

TLm Crassostrea gigas (oysters) 1.9 ppm/hr in salt water /Conditions of bioassay not specified/ /Cupric nitrate trihydrate/

EC50 Selenastrum capricornatum (green alga) 85 ug/l/14 days /Cell volume bioassay/

EC50 Thalassiosira pseudonana (alga, saltwater) 5 ug/l/72 hr /Growth rate bioassay/

EC50 Nitschia closterium (alga, saltwater) 33 ug/l/96 hr /Growth rate bioassay/

For more Ecotoxicity Values (Complete) data for COPPER(II) NITRATE (8 total), please visit the HSDB record page.

Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes become saturated and copper accumulates in the nucleus, causing nuclear damage. This damage is possibly a result of oxidative damage, including lipid peroxidation. Copper inhibits the sulfhydryl group enzymes such as glucose-6-phosphate 1-dehydrogenase, glutathione reductase, and paraoxonases, which protect the cell from free oxygen radicals. It also influences gene expression and is a co-factor for oxidative enzymes such as cytochrome C oxidase and lysyl oxidase. In addition, the oxidative stress induced by copper is thought to activate acid sphingomyelinase, which lead to the production of ceramide, an apoptotic signal, as well as cause hemolytic anemia. Copper-induced emesis results from stimulation of the vagus nerve. Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613, L277, T49, A174, L280)

Breathing high levels of copper can cause irritation of the nose and throat. Ingesting high levels of copper can cause nausea, vomiting, diarrhea, headache, dizziness, and respiratory difficulty. Nitrate and nitrite poisoning causes methemoglobinemia. Symptoms include cyanosis, cardiac dysrhythmias and circulatory failure, and progressive central nervous system (CNS) effects. CNS effects can range from mild dizziness and lethargy to coma and convulsions. (L1137, L278, L279)

In Chinese hamster V79 cells, copper(II) nitrate produced dose-related incr in the mutation frequency (resistance to 8-azaguanine at 0.01 & 0.1 mmol/liter & in the frequency of sister chromatiD exchanges at 0.01-0.5 mmol/liter. /There was also/ an incr in the molecular weight of DNA isolated from the cells, which was attributed to binding of the copper ions to the DNA.

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Copper and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Start an IV with lactated Ringer's /SRP: "To keep open", minimal flow rate/. Watch for signs of fluid overload. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine, hydrochloride to assist eye irrigation ... . /Copper and related compounds/

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.4 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Cupric nitrate is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance.

Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Copper and cmpd/

Copper is mainly absorbed through the gastrointestinal tract, but it can also be inhalated and absorbed dermally. It passes through the basolateral membrane, possibly via regulatory copper transporters, and is transported to the liver and kidney bound to serum albumin. The liver is the critical organ for copper homoeostasis. In the liver and other tissues, copper is stored bound to metallothionein, amino acids, and in association with copper-dependent enzymes, then partitioned for excretion through the bile or incorporation into intra- and extracellular proteins. The transport of copper to the peripheral tissues is accomplished through the plasma attached to serum albumin, ceruloplasmin or low-molecular-weight complexes. Copper may induce the production of metallothionein and ceruloplasmin. The membrane-bound copper transporting adenosine triphosphatase (Cu-ATPase) transports copper ions into and out of cells. Physiologically normal levels of copper in the body are held constant by alterations in the rate and amount of copper absorption, compartmental distribution, and excretion. Intake of some amount of nitrates and nitrites is a normal part of the nitrogen cycle in humans. In vivo conversion of nitrates to nitrites can occur in the gastrointestional tract under the right conditions, significantly enhancing nitrates' toxic potency. The major metabolic pathway for nitrate is conversion to nitrite, and then to ammonia. Nitrites, nitrates, and their metabolites are excreted in the urine. (L1137, L277, L279)

Used in light sensitive reproductive papers, nickel plating baths, pesticides (wood preservatives, fungicides, herbicides, and insecticides), pyrotechnic compositions, aluminum brighteners, solid rocket fuel catalysts, paints/varnishes, drugs, flotation of cinnabar, cancer treatment, electrolysis and electroplating, and electronics; Also used as a ceramic color, a mordant and oxidant in textile dyeing and printing, a metal coloring reagent (burnishing iron, giving a black antique finish to copper, and coloring zinc brown), a nitrating agent for aromatic organosilicon compounds, an organic catalyst, a drilling mud dispersant, and a corrosion inhibitor; [HSDB]

Aluminum Producing [Category: Industry]

Ceramics making [Category: Hobbies]

For Copper(II) nitrate(USEPA/OPP Pesticide Code: 076102) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

In light sensitive reproductive papers; as ceramic color; as mordant and oxidant in textile dyeing and printing; as reagent for burnishing iron, for giving a black "antique" finish to copper; for coloring zinc brown; in nickel plating baths; in aluminum brighteners; in wood preservatives, fungicides, herbicides; in pyrotechnic compositions; as catalyst component in solid rocket fuel; as nitrating agent for aromatic organosilicon cmpd; as catalyst for organic reactions.

Glaze/ceramics ingredient; pyrotechnic/rocket fuel ingredient; mordant/oxidizing agent (textile dyeing); metal surface treatments agent

By treating copper or copper oxide with nitric acid. The solution is evaporated and product recovered by crystallization. /Hydrated salts/

... Sublimation of copper(II) nitrate under vacuum from ... mixt of copper(II) bromide and silver nitrate at about 200 °C. ...

Dissolving copper in nitric acid solution; dissolving copper(II) oxide, basic copper(II) carbonate or copper(II) hydroxide in nitric acid solution.

USEPA/OPP Pesticide Code 076102; Trade Names: None listed.

Grades: Technical; CP

Grade of purity: Pure, 100% ... /&/ reagent. /Trihydrate/

Gmelin's Copper (8th) 60B, 164-179 (1958); Addison, Hathaway, J Chem Soc 1958, 3099.

Petroleum Refineries

Nitric acid, copper(2+) salt (2:1): ACTIVE