Mifepristone
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Grundinformationen
- CAS
84371-65-3- Standard-SMILES
CC#C[C@]1(O)CCC2C3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)C)cc3)C[C@@]21C- Summenformel
- C29H35NO2
- Durchschnittliche Molmasse
- 429,59 g/mol
Namen und Bezeichner
- Bevorzugter Name
- Mifepristone
- Englischer Name
- Mifepristone
- Summenformel
- C29H35NO2
- Molmasse
- 429.59
Namen und Synonyme
RU486MifeprestoneMifepristone INN(8S,11R,13S,14S,17S)-11-(4-(Dimethylamino)phenyl)-17-hydroxy-13-methyl-17-(prop-1-yn-1-yl)-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-oneC-1073r38486ru486-6VGX 410MIFEGYNERU-38486
Datenbank-Bezeichner
- CAS
84371-65-3- PubChem CID
- 18649237
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 195 · 195-198°C
- Siedepunkt
- 544.13 °C · 544.13°C (rough estimate)
- Dichte
- 1.0731 · 1.0731 (rough estimate)
- Brechungsindex
- 1.629 · 1.6290 (estimate)
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml).
- Aggregatzustand
- Yellow solid
- pka
- 12.94 · 12.94±0.60(Predicted)
- Farbe
- Yellow
- Biologische Quelle
- synthetic (organic)
- Wasserlöslichkeit
- 474.8 ug/L · 474.8ug/L(22.5 ºC)
- Merck
- 14 · 14,6186
- Henry's Law Constant
- 2 · 2.0×10-1 mol/(m3Pa) at 25℃, HSDB (2015)
- Stabilität
- 1 year · Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- InChIKey
- VKHAHZOOUSRJNA-GCNJZUOMSA-N
- SMILES
- [H][C@@]12CCC3=CC(=O)CCC3=C1[C@H](C[C@@]4(C)[C@@]2([H])CC[C@@]4(O)C#CC)c5ccc(cc5)N(C)C
- CAS Datenbank
- 84371 · 84371-65-3(CAS DataBase Reference)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- hs_code
- 29372900
- RTECS-Nr.
- KG2955000
- risk_code
- 60-61
- hazard_code
- T
- safety_code
- 53-22-36/37/39-45
- Speicherklasse
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- Giftige Stoffe Daten
- 84371-65-3(Hazardous Substances Data)
- Hazard Classifications
- Repr. 1B
Chemie und Industrie
Anwendungen
BeschreibungMifepristone is an orally-active progesterone and glucocorticoid receptor antagonist indicated for use as a post-coital contraceptive. In addition to being an abortifacient, mifepristone is reported to be effective in the treatment of ocular hypertension; its potential therapeutic effect in hormone-dependent tumors is currently under investigation.
HistoryMifepristone (brand name: Mifeprex) is an abortion drug approved by the FDA in 2000 for the medical termination of pregnancy, up to 7 weeks of gestation, an extension extended to 10 weeks in 2016. A generic version of Mifeprex, mifepristone tablets (200 mg), was approved in 2019. The drug has been in use for 25 years. However, following a study by the Center for Ethics and Public Policy (EPPC) showing that nearly 11% of women using the drug experience serious adverse events, the FDA is reviewing the safety of mifepristone.
VerwendenMifepristone is a progesterone receptor antagonist with partial agonist activity. Abortifacient.
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