N-Methyl-9-pentofuranosyl-9H-purin-6-amine
Grundinformationen
- CAS
1867-73-8- Standard-SMILES
CNc1ncnc2c1ncn2C1OC(CO)C(O)C1O- InChIKey
VQAYFKKCNSOZKM-UHFFFAOYSA-N- Summenformel
- C11H15N5O4
- Durchschnittliche Molmasse
- 281,27 g/mol
- Monoisotopische Masse
- 281,11240398
Überblick
Adenosine, N-methyl- is a purine nucleoside.
Namen und Bezeichner
- Bevorzugter Name
- N-Methyl-9-pentofuranosyl-9H-purin-6-amine
- IUPAC
- 2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolane-3,4-diol
- Englischer Name
- 6-Methylaminopurine 9-ribofuranoside
- Summenformel
- C11H15N5O4
- Molmasse
- 281.27
Namen und Synonyme
n-methyl-9-pentofuranosyl-9h-purin-6-amineRefChem:1091905DTXCID80209074DTXSID90859685NSC 294096-Methyladenosine;N-Methyladenosine6-Methylaminopurine 9-ribofuranosideNSC627045N6-Me-AdenosineOprea1_576536SCHEMBL23647923CHEBI:182179
Weitere Namen anzeigen
N6-METHYLADENOSINECS-1297N6-Me-AN6-Me-rAN6-Me-ArNSC-29409N-MethyladenosineAdenosine, N-methyl-N6,N6-Methyladenosin
VQAYFKKCNSOZKM-UHFFFAOYSA-NHMS3373K08HMS3652E11NSC29409NSC971132-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolane-3,4-diolNSC-97113NSC409168
Datenbank-Bezeichner
- CAS
1867-73-8、60209-41-8、65494-95-3- PubChem CID
- 1869
- ChEBI
CHEBI:182179
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- -0,4
- Polarare Oberfläche (TPSA)
- 126 Ų
- H-Brücken-Donoren
- 4
- H-Brücken-Akzeptoren
- 8
- Frei drehbare Bindungen
- 3
- Schwere Atome
- 20
- Formalladung
- 0
- Komplexität
- 349
Physikochemische Eigenschaften
- Schmelzpunkt
- 172 °C · 172 °C
- Siedepunkt
- 649.1 · 649.1±65.0 °C(Predicted)
- Dichte
- 1.85 · 1.85±0.1 g/cm3(Predicted)
- storage temp.
- 2 · Keep in dark place,Sealed in dry,2-8°C
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
- pka
- 13.12 · 13.12±0.70(Predicted)
- Aggregatzustand
- Powder
- Farbe
- White to off-white
- PH
- 4 · 4.0
- Stabilität
- Hygroscopic
- InChI
- InChI=1S/C11H15N5O4/c1-12-9-6-10(14-3-13-9)16(4-15-6)11-8(19)7(18)5(2-17)20-11/h3-5,7-8,11,17-19H,2H2,1H3,(H,12,13,14)/t5-,7-,8-,11-/m1/s1
- InChIKey
- VQAYFKKCNSOZKM-IOSLPCCCSA-N
- SMILES
- OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)NC)N=C2)[C@H](O)[C@@H]1O
Chemie und Industrie
Anwendungen
BeschreibungN6-Methyladenosine is an adenosine analog. It inhibits epinephrine-induced contraction of isolated guinea pig ileum and thoracic aorta when used at a concentration of 10 μM. N6-Methyladenosine (1 mg/kg, i.v.) decreases arterial blood pressure and renal blood flow and increases peripheral resistance in anesthetized dogs. It also inhibits tumor growth in the C3H/ST and C3HB/ST mouse models of spontaneous mammary adenocarcinomas. N6-Methyladenosine is also the most prevelant mRNA modification in eukaryotes and has roles in cell viability and development.
VerwendenN6-Methyladenosine is the most common internal modification of eukaryotic mRNA. The result of this modification is specifically recognized mRNA in the cytoplasm which regulates mRNA stability.N6-Methyladenosine is made when a protein complex containin the writer enzyme METTL3 adds a methyl group to adenosine. Two different eraser enzymes ALKBH5 and FTO can remove a methyl group to turn m6A bach into adenosine.
Vor- und nachgelagerte Produkte
Nachgelagerte Produkte
Anbieter100 Anbieter
湖北永阔科技有限公司027-59223108 15972152991 · [email protected]
陕西缔都新材料有限公司81124267 17392282731 · [email protected]
湖北威德利化学试剂有限公司186-02735115 18062128043 · [email protected]
Zugehörige Reaktionen
0
Keine Reaktionsaufzeichnungen unter den aktuellen Filterkriterien.
Notizen zur Verbindung
Wird geladen…