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HCID 18746Erstellt: 27. Oktober 2026

Nickel carbonate

[Carbonato(2-)-κO]nickel · Nickel, [carbonato(2-)-κO]-

https://huagongshe.com/de/chemical/18746

Molekülstruktur von Nickel carbonate

Identifikatoren & physikalische Daten

CAS No.16337-84-1
SummenformelNiCO3
Durchschnittliche Molmasse118,702 g/mol
Monoisotopische Masse117,92008676 g/mol
SMILESO=C([O-])[O-].[Ni+2]
InChIKeyZULUUIKRFGGGTL-UHFFFAOYSA-L
PubChem CID18746
EC No.222-068-2
DTXSIDDTXSID201333983

Chemische & physikalische Eigenschaften

Polarare Oberfläche (TPSA)63,2
H-Brücken-Donoren0
H-Brücken-Akzeptoren3
Frei drehbare Bindungen0
Schwere Atome5
Formalladung0
Komplexität18,8
StoffklassenMetals -> Nickel Compounds, InorganicCarcinogens
Dichte4.39 g/cu cm2.6 g/cm³4.39 @25 °C
Color/FormGreen rhombohedral crystals
Löslichkeit93 mg/l water @ 25 °CSoluble in dilute acidsSolubility in water, mg/l at 25 °C: 93 (practically insoluble)
DecompositionToxic gases and vapors (such as nickel carbonyl) may be released ... in the decomp of nickel cmpd. /Nickel & sol nickel cmpd/
SchmelzpunktDECOMPOSES BEFORE REACHING MELTING POINT.No melting pointdecomposes on heating
Physical DescriptionLiquidDry PowderOther SolidGreen crystals[HSDB] Nearly insoluble in water[Ullmann]LIGHT GREEN CRYSTALS.

Sicherheit & Vorschriften

GHS-EinstufungDangerH302: Harmful if swallowed [Warning Acute toxicity, oral]P203, P233, P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P317, P302+P352, P304+P340, P317, P318, P319, P321, P330, P332+P317, P333+P317, P342+P316, P362+P364, P391, P403, P405, and P501 (click each P-code to see the statement)
Regulatorische InformationenChemical: Carbonic acid, nickel(2+) salt (1:1)Hazard Traits - CarcinogenicityReproductive ToxicityRespiratory ToxicityCarbonic acid, nickel(2+) salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Carbonic acid, nickel(2+) salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Restricted substance: Nickel carbonateCarbonic acid, nickel(2+) salt (1:1): Does not have an individual approval but may be used under an appropriate group standard
Weitere SicherheitsinformationenIMAP assessments - Nickel carbonates: Human health tier II assessment
BrandgefahrenNot combustible. Gives off irritating or toxic fumes (or gases) in a fire.
GefahrenübersichtA skin irritantMay cause skin sensitization and asthma after prolonged contact[ICSC] Danger of skin and airway sensitization[MAK] See Nickel and linked occupational diseases.
EG-EinstufungSymbol: Xn, NR: 22-40-43-50/53S: (2)-22-36/37-60-61
UN-EinstufungUN Hazard Class: 6.1UN Pack Group: III
OSHA StandardsVacated 1989 OSHA PEL TWA 0.1 mg/cu m is still enforced in some states. /Nickel soluble compounds, as Ni/Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 1 mg/cu m. /Nickel, metal and insoluble cmpd, as Ni/
LuftstandardsListed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Nickel carbonate is included on this list.
Chemical DangersDecomposes on heating and on contact with acids. This produces carbon dioxide (see ICSC 0021). This produces toxic fumes of nickel monoxide. See ICSC 0926.
Packaging and LabellingDo not transport with food and feedstuffs.
Toxic Combustion ProductsToxic gases and vapors (such as nickel carbonyl) may be released in a fire involving nickel ... /Nickel & sol nickel cmpd/
NIOSH RecommendationsNIOSH considers nickel metal and other compounds (as Ni) to be a potential occupational carcinogen. /Nickel metal and other compounds (as Ni)/NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concentration. /Nickel metal and other compounds (as Ni)/Recommended Exposure Limit: 10 Hr TWA 0.015 mg/cu m. /Nickel metal and other compounds (as Ni)/
BrandbekämpfungIn case of fire in the surroundings, use appropriate extinguishing media.
Erste-Hilfe-MaßnahmenFresh air, rest. Refer for medical attention.Wear protective gloves when administering first aid. Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Refer for medical attention .
Sichere LagerungStore only in original packaging. Separated from food and feedstuffs and acids. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.
EntsorgungsverfahrenSRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
Verschüttetes entsorgenPersonal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Preventive MeasuresSRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers.SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
Eye PreventionWear safety goggles or eye protection in combination with breathing protection.
Inhalation RiskEvaporation at 20 °C is negligiblea harmful concentration of airborne particles can, however, be reached quickly when dispersed.
Skin PreventionProtective gloves. Protective clothing.
Minimum Risk LevelChronic Inhalation: 0.0001 mg/m3 (L134) Intermediate Oral: 0.01 mg/kg/day (L134)
Exposure PreventionAVOID ALL CONTACT!
Ingestion PreventionDo not eat, drink, or smoke during work.
TreatmentExcess exposure to nickel is usually handled by preventing further exposure and symptomatic treatment. Nickel poisoning may also be treated using chelation therapy with sodium diethyldithiocarbamate. (L42)
Gesundheitliche AuswirkungenThe most common harmful health effect of nickel in humans is an allergic reaction. This usually manifests as a skin rash, although some people experience asthma attacks. Long term inhahation of nickel causes chronic bronchitis and reduced lung function, as well as damage to the naval cavity. Ingestion of excess nickel results in damage to the stomach, blood, liver, kidneys, and immune system, as well as having adverse effects on reproduction and development. (L41)
UmweltverhaltenAquatic Fate: Under aerobic conditions and pH below 9 ... nickel forms with ... carbonate ... /and is/ sufficiently soluble to maintain aqueous an Ni(2+) concn above 10-6 M (60 ug/l). Above pH 9, precipitation of the ... carbonate exhibits some control on nickel mobility.
Unerwünschte WirkungenSkin Sensitizer - An agent that can induce an allergic reaction in the skin.
ExpositionspfadeThe substance can be absorbed into the body by inhalation of its aerosol and by ingestion.Inhalation (L41)oral (L41)dermal (L41)
Toxizitätsübersicht... Nickel carbonate is insoluble in water. ... Respiratory absorption with secondary gastrointestinal absorption of nickel (insoluble compounds) is the major route of entry during occupational exposure. A significant quantity of inhaled material is swallowed following mucocillary clearance from the respiratory tract. Poor personal hygiene & work practices can contribute to gastrointestinal exposure. Percutaneous absorption is negligible, quanitatively, but is important in the pathogenesis of contact hypersensitivity. Absorption is related to the solubility of the compound /& nickel carbonate is classified as an insoluble salt/. Nickel carbonate ... induced local mesenchymal tumors in a variety of experimental animals after im, sc, ip, intrapleural, intraocular, intraosseous, intrarenal, intra-articular, intratesticular or intra-adipose administration.Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promote cell proliferation. Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. Nickel has also been shown to alter several transcription factors, including hypoxia-inducible transcription factor, activating transcription factor, and NF-KB transcription factor. There is also evidence that nickel ions inhibit DNA repair, either by directly inhibiting DNA repair enzymes or competing with zinc ions for binding to zinc-finger DNA binding proteins, resulting in structural changes in DNA that prevent repair enzymes from binding. Nickel ions can also complex with a number of cellular ligands including amino acids, peptides, and proteins resulting in the generation of oxygen radicals, which induce base damage, DNA strand breaks, and DNA protein crosslinks. (L41, A40)
Signs and SymptomsCough.Redness. Pain.Symptoms of nickel poisoning include headache, nausea, vomiting, dizziness, irritability, and difficulty sleeping, followed by chest pains, sweating, rapid heart beat, and a dry cough. (L42)
ICSC Environmental DataThe substance is very toxic to aquatic organisms. The substance may cause long-term effects in the aquatic environment. It is strongly advised not to let the chemical enter into the environment.
Human Toxicity ExcerptsHuman peripheral lymphocytes were incubated 4 hr with 50 uM nickel carbonate. Nickel carbonate formed paracrystalline particles apparently with albumin, histidine, and lysine of the culture mediumthe particles were accumulated along the cell membranes of the lymphocytes (both outside and inside of the cells) especially in lymphocytes from subjects with nickel allergy. Lymphocytes from normal subjects formed more phagocytic pseudopodia than lymphocytes from the sensitized subjects.
Carcinogen Classification1, carcinogenic to humans. (L135)
Non-Human Toxicity ExcerptsNICKEL CARBONATE ... ADDED TO DIET OF YOUNG RATS AT 250, 500, & 1000 PPM FOR 8 WK, HAD NO SIGNIFICANT EFFECT ON GROWTH RATE. ... /WHEN/ FED TO MONKEYS (MACACA SINICUS) AT THE SAME DIETARY LEVELS FOR 24 WK ... NO SIGNIFICANT CHANGES IN GROWTH, HEMATOLOGIC VARIABLES, OR BEHAVIOR /WERE OBSERVED/.... DOGS & CATS FED UP TO 1000 PPM IN ... DIET AS ... NICKEL CARBONATE ON CHRONIC BASIS SHOWED NO DELETERIOUS EFFECTS.... /NICKEL CARBONATE (7 MG)/ FORMED INTO PELLETS WITH SHEEP FAT /WAS IMPLANTED/ INTO MUSCLE (UNSPECIFIED) OF GROUPS OF 35 NIH BLACK RATS /BY 3 SURGICAL IMPLANTATIONS/. PELLETS OF SHEEP FAT ALONE WERE SIMILARILY IMPLANTED IN CONTROL GROUP OF 35 RATS. AFTER 18 MO ... 6/35 RATS IMPLANTED WITH NICKEL CARBONATE HAD DEVELOPED SARCOMAS AT SITE OF IMPLANTATION. /NO TUMORS OBSERVED IN CONTROL/ (PAYNE, 1964)... When nickel carbonate was added to cattle diets, no toxicity was observed at 250 ppm nickel.
Evidence for CarcinogenicityA1: Confirmed human carcinogen. /Nickel, as Ni, Insoluble inorganic compounds (NOS)/Evaluation: There is sufficient evidence in humans for the carcinogenicity of nickel sulfate, and of the combinations of nickel sulfides and oxides encountered in the nickel refining industry. There is inadequate evidence in humans for the carcinogenicity of metallic nickel and nickel alloys. There is sufficient evidence in experimental animals for the carcinogenicity of metallic nickel, nickel monoxides, nickel hydroxides and crystalline nickel sulfides. There is limited evidence in experimental animals for the carcinogenicity of nickel alloys, nickelocene, nickel carbonyl, nickel salts, nickel arsenides, nickel antimonide, nickel selenides and nickel telluride. There is inadequate evidence in experimental animals for the carcinogenicity of nickel trioxide, amorphous nickel sulfide and nickel titanate. The Working Group made the overall evaluation on nickel compounds as a group on the basis of the combined results of epidemiological studies, carcinogenicity studies in experimental animals, and several types of other relevant data, supported by the underlying concept that nickel compounds can generate nickel ions at critical sites in their target cells. Overall evaluation: Nickel compounds are carcinogenic to humans (Group 1). Metallic nickel is possibly carcinogenic to humans (Group 2B). /Nickel compounds/
Clean Water Act AnforderungenToxic pollutant designated pursuant to section 307(a)(1) of the Clean Water Act and is subject to effluent limitations. /Nickel and compounds/
State Drinking Water Standards(CA) CALIFORNIA 100 ug/L /Nickel/(CT) CONNECTICUT 100 ug/L /Nickel/(DE) DELAWARE 100 ug/L /Nickel/(FL) FLORIDA 100 ug/L /Nickel/(WI) WISCONSIN 100 ug/L /Nickel/
Landesrichtlinien für Trinkwasser(AZ) ARIZONA 150 ug/L /Nickel/(MA) MASSACHUSETTS 100 ug/L /Nickel/(ME) MAINE 140 ug/L /Nickel/(MN) MINNESOTA 100 ug/L /Nickel/
Bundesrichtlinien für TrinkwasserEPA 100 ug/L /Nickel/