HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
7-Benzyl-6-methyl-6,7-dihydroquinazolino[3,2-a][1,4]benzodiazepine-5,13-dione
benzomalvin A · Quinazolino[3,2-a][1,4]benzodiazepine-5,13-dione, 6,7-dihydro-6-methyl-7-(phenylmethyl)-, (6S,7S)-
![Molekülstruktur von 7-Benzyl-6-methyl-6,7-dihydroquinazolino[3,2-a][1,4]benzodiazepine-5,13-dione](/img/chemical/190863.png)
Identifikatoren & physikalische Daten
| CAS No. | 157047-96-6 |
|---|---|
| Summenformel | C24H19N3O2 |
| Durchschnittliche Molmasse | 381,435 g/mol |
| Monoisotopische Masse | 381,14772685 g/mol |
| SMILES | CN1C(=O)c2ccccc2-n2c(nc3ccccc3c2=O)C1Cc1ccccc1 |
| InChIKey | YYWUABJYAOCACI-UHFFFAOYSA-N |
| PubChem CID | 190863 |
| DTXSID | DTXSID90935599 |
Chemische & physikalische Eigenschaften
| Siedepunkt | 599.3±60.0 °C(Predicted) |
|---|---|
| Dichte | 1.28±0.1 g/cm3(Predicted) |
| Lagerbedingungen | Store at -20°C |
| Löslichkeit | DMF: SolubleDMSO: SolubleEthanol: SolubleMethanol: Soluble |
| Aggregatzustand | A solid |
| pKa (Säurekonstante) | -0.46±0.40(Predicted) |
Anwendungen & Verwendung
Beschreibung
Benzomalvin A is a fungal metabolite produced by Penicillium. It inhibits yeast α-glucosidase in vitro (IC50 = 383.2 μM). In vivo, benzomalvin A (3.1-31.6 mg/kg) decreases plasma glucose levels in mice following administration of sucrose. It also decreases the plasma glucose postprandial peak in nicotinamide-streptozotocin-induced hyperglycemic mice when administered at a dose of 10 mg/kg. Benzomalvin A also acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P to guinea pig, rat, and human NK1 (Kis = 12, 42, and 43 μM, respectively).