Neomycin B-sulfat

Framycin sulfate · neomycin B sulphate · Chlorotoluron Impurity 5 · Neomycin B Sulfate (Framycetin Sulfate) · 2nd International Standard for Neomycin B · Framycetin sulfate (Neomycin B sulfate) RS · (2S,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-diamino-2-(((2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-6-hydroxycyclohexyl) · (2S,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-diamino-2-(((2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)tetrahydro-2H-pyran-3,4-diol xsulfate

https://huagongshe.com/de/chemical/197162

Identifikatoren & physikalische Daten

CAS No.	1405-10-3
Summenformel	C23H48N6O17S
Durchschnittliche Molmasse	712,7 g/mol
Monoisotopische Masse	712,27966508 g/mol
SMILES	NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O.O=S(=O)(O)O
InChIKey	OIXVKQDWLFHVGR-WQDIDPJDSA-N
PubChem CID	197162
ChEMBL	CHEMBL1950493
ChEBI	CHEBI:53636
EC No.	215-773-1
DTXSID	DTXSID10948247
Lokaler Name	Neomycin B-sulfat

Chemische & physikalische Eigenschaften

Polarare Oberfläche (TPSA)	436
H-Brücken-Donoren	15
H-Brücken-Akzeptoren	23
Frei drehbare Bindungen	9
Schwere Atome	47
Formalladung	0
Komplexität	953
Human Drugs	Breast FeedingLactationMilk, HumanAnti-Infective AgentsAntibacterial AgentsAminoglycosidesDermatologic AgentsFDA approved drugs -> Active ingredient
Animal Drugs	Active Ingredients (Neomycin Sulfate) -> FDA Greenbook
Lagerbedingungen	-20°C
Aggregatzustand	solid
Hauptanwendungen	USP Biologicspharmaceutical
InChIKey	OIXVKQDWLFHVGR-WQDIDPJDSA-N

Sicherheit & Vorschriften

GHS-Einstufung	DangerH317 (95.7%): May cause an allergic skin reaction [Warning Sensitization, Skin]P203, P233, P260, P261, P271, P272, P273, P280, P284, P302+P352, P304+P340, P318, P319, P321, P333+P317, P342+P316, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 372 reports by companies from 27 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.This chemical does not meet GHS hazard criteria for 96.3% (52 of 54) of all reports.Not Classified
Regulatorische Informationen	Hazard Traits - Developmental ToxicityNeomycin sulphate: Does not have an individual approval but may be used under an appropriate group standardFramycetin sulfate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Weitere Sicherheitsinformationen	IMAP assessments - Neomycin, sulfate (salt): Human health tier I assessment
Hazard Classes and Categories	Not ClassifiedSkin Sens. 1 (95.7%)Acute Tox. 4 (15.4%)
Treatment	Hemodialysis will remove neomycin sulfate from the blood. (L1712)
Gesundheitliche Auswirkungen	Antibiotic resistance
Expositionspfade	Eye contacttopical (eye drops). Poorly absorbed from the normal gastrointestinal tract. Although only approximately 3% of neomycin is absorbed through intact intestinal mucosa, significant amounts may be absorbed through ulcerated or denuded mucosa or if inflammation is present.
Toxizitätsübersicht	Aminoglycosides like neomycin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically neomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.

Anwendungen & Verwendung

Verwenden

Neomycin B Trisulfate is a trisulfate salt analog of Neomycin B (N389983), which is an aminoglycoside antibiotic.