Calcium propionate

Fungicides

Active substance -> EU Pesticides database: Not approved

COLORLESS, MONOCLINIC TABLETS

Powder or monoclinic crystals

White powder

SOLUBILITY IN 49 G/100 CC WATER @ 0 °C; 55.8 G/100 CC WATER @ 100 °C /HYDRATE/

Sol in water; slightly sol in methanol, ethanol; practically insol in acetone, benzene.

INSOL IN ALCOHOL

Dry Powder; CBI; Liquid

White crystalline powder

Colorless or white Solid; Soluble in water; [HSDB] White powder; Soluble in water; [MSDSonline]

This chemical does not meet GHS hazard criteria for 20.5% (69 of 337) of reports.

Danger

H318 (78.6%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

P264+P265, P280, P305+P354+P338, and P317 (click each P-code to see the statement)

Aggregated GHS information provided per 337 reports by companies from 7 notifications to the ECHA C&L Inventory.

Danger

Chemical: Propanoic acid, calcium salt

Regulation (EC) No 257/2010

Propanoic acid, calcium salt (2:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Propanoic acid, calcium salt (2:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Reg. (EU) 2022/1443

Status: Active Update: 17-11-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/5706

Calcium propionate: Does not have an individual approval but may be used under an appropriate group standard

As the federal pesticide law FIFRA direct, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA 88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Calcium propionate is found on List D. Case No: 4078; Case Status: RED Approved 09/91 - OPP has made a decision that some/all uses of the pesticide are eligible for reregistration, as reflected in a Reregistration Eligibility Decision (RED) Document. Active ingredient (AI): Calcium propionate; AI Status: Cancelled - The active ingredient is no longer contained in any registered pesticide product. Thus, we characterize it as cancelled.

Eye Dam. 1 (78.6%)

Eye damage - category 1

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

/IN RATS/ SODIUM OR CALCIUM PROPIONATE HAD NO EFFECT ON GROWTH WHEN FED AT LEVELS OF 1 TO 3 G DAILY, FOR 4 TO 5 WK, BEGINNING WHEN ANIMALS WERE ABOUT 4 WK OF AGE.

... A LEVEL OF 5% /SODIUM OR CALCIUM/ PROPIONATE WAS PLACED IN BREAD BEFORE BAKING AND ... FED AS THREE-FOURTHS OF DIET OF RATS FOR ONE YEAR. THERE WAS NO DISCERNIBLE TOXICITY IN SPITE OF PRESENCE OF THREE OTHER ... ADDITIVES AT HIGH CONCN IN DIET.

LD50 Rat oral 3920 mg/kg

LD50 Mouse oral 2350 mg/kg

As the federal pesticide law FIFRA direct, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA 88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Calcium propionate is found on List D. Case No: 4078; Case Status: RED Approved 09/91 - OPP has made a decision that some/all uses of the pesticide are eligible for reregistration, as reflected in a Reregistration Eligibility Decision (RED) Document. Active ingredient (AI): Calcium propionate; AI Status: Cancelled - The active ingredient is no longer contained in any registered pesticide product. Thus, we characterize it as cancelled.

Used as a preservative in foods, tobacco, feed grain, cosmetics, and pharmaceuticals; Has been used in the production of butyl rubber and as an antifungal drug; [HSDB]

Farming (Feed Additives) [Category: Industry]

Active ingredient (AI): Calcium propionate; AI Status: Cancelled - The active ingredient is no longer contained in any registered pesticide product.

Inhibitor of molds & other microorganisms in foods, tobacco, pharmaceuticals; in butyl rubber to improve processability and scorching resistance.

THERAP CAT: Antifungal agent

Feed grain preservative

(1972) NEGLIGIBLE

(1975) NEGLIGIBLE

(1972) NEGLIGIBLE

(1975) NEGLIGIBLE

(1984) 7.56X10+7 g /propionates/

2023: 250,000 - <400,000 lb

(1972) 9.71X10+9 GRAMS

(1975) PROBABLY GREATER THAN 9.08X10+5 GRAMS

(1984) 8.51X10+9 g

(1993) 16,382 kg

ABOUT 80% AS AN ANTIFUNGAL FOOD ADDITIVE IN BAKED GOODS, MOSTLY IN BREAD; ABOUT 20% AS AN ANTIFUNGAL AGENT IN OTHER APPLICATIONS, PRINCPLY AS AN ADDITIVE IN PROCESSED CHEESE (1973)

Mold inhibitor-Baked goods, 80%; Feed grain preservative, 10%; and Misc, 10% (1983) /Sodium & calcium propionate/

Food additives

Food Additives -> PRESERVATIVE -> JECFA Functional Classes

Food Additives -> PRESERVATIVE -> JECFA Functional Classes

Cosmetics -> Preservative

Food, beverage, and tobacco product manufacturing

Propanoic acid, calcium salt (2:1): ACTIVE

PROPIONATE COMPOUND IS A MIXTURE CONTAINING 10% EACH OF CALCIUM AND SODIUM PROPIONATES IN A JELLY FOR LOCAL APPLICATION. ... IS USED IN TREATMENT OF VULVOVAGINAL MONILIASIS.

BECAUSE PROPIONATE INHIBITS MOLD AND SPARES YEAST, IT HAS SUPERSEDED THE ACID PHOSPHATE AS AN ANTI-ROPE AGENT. /PROPIONATE/

... FOUND THAT BREAD WHICH CONTAINED 0.2% OF PROPIONATE (BASIS TOTAL DOUGH WEIGHT) SHOWED NO VISIBLE MOLD FOR OVER 8 DAYS IN BOTH WRAPPED AND UNWRAPPED CONDITION AT ROOM TEMP. /PROPIONATE/

... REPORTED THAT, FOR BREAD, 0.2% ... BY FLOUR WT EXTENDED MOLD-FREE LIFE TO SIX DAYS, AS COMPARED WITH FOUR DAYS FOR UNTREATED LOAVES. NO ODOR PROBLEMS WERE FOUND AT THIS LEVEL.