Milbemycin, oxime
Grundinformationen
- CAS
129496-10-2- Standard-SMILES
CC1=C[C@H]2C(=O)O[C@H]3C[C@@H](C/C=C(\C)C[C@@H](C)/C=C/C=C4\CO[C@H](/C1=N\O)[C@@]42O)O[C@@]1(CC[C@H](C)[C@@H](C)O1)C3.CC[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)C[C@@H](C)/C=C/C=C3\CO[C@@H]4/C(=N\O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2- InChIKey
LKMMLHTWKLEARD-MGZQXKBQSA-N- Summenformel
- C63H88N2O14
- Durchschnittliche Molmasse
- 1.097,4 g/mol
- Monoisotopische Masse
- 1.096,62355549
Überblick
used for heartworm (Dirofilaria immitis) and mites in dogs
Namen und Bezeichner
- Bevorzugter Name
- Milbemycin, oxime
- IUPAC
- (1R,4S,5'S,6R,6'R,8R,10E,13R,14E,16E,20R,21Z,24S)-6'-ethyl-24-hydroxy-21-hydroxyimino-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one;(1R,4S,5'S,6R,6'R,8R,10E,13R,14E,16E,20R,21Z,24S)-24-hydroxy-21-hydroxyimino-5',6',11,13,22-pentamethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
- Englischer Name
- Milbemycin oxime
- Summenformel
- 2C32H45NO7.2C31H43NO7
- Molmasse
- 2194.78
Namen und Synonyme
Milbemycin oximeInterceptor flavor tabsMilbemiteMilbeGuardCGA-1792460502PUN0GTMilbemite Otic SolutionMILBEGUARD FLAVOREDTRIFEXIS COMPONENT MILBEMYCIN OXIMENEXGARD SPECTRA COMPONENT MILBEMYCIN OXIMERefChem:66538DTXCID40819951
Weitere Namen anzeigen
MilbeximeMibemycin oximeMilbemyein oximeMilbemycin oxime CRSβ-phenylacrylophenoneMilbemycin oxime 92~95%Milbemycin Oxime (200 mg)Milbemycin Oxime (1443806)
DTXSID501057491129496-10-2DTXSID4058495Milbemycin, oximeMilbemycin A, 5-oximeSentinel flavor tabsUNII-0502PUN0GTMilbemycin oxime (Standard)
Datenbank-Bezeichner
- CAS
129496-10-2
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 214 Ų
- H-Brücken-Donoren
- 4
- H-Brücken-Akzeptoren
- 16
- Frei drehbare Bindungen
- 1
- Schwere Atome
- 79
- Formalladung
- 0
- Komplexität
- 2.260
Experimentelle und physikochemische Eigenschaften
Animal DrugsFDA approved animal drugs -> Active ingredient
Physikochemische Eigenschaften
- Schmelzpunkt
- 169.6 · 169.6-177.4°
- Flammpunkt
- 412 ℃ · 412℃
- storage temp.
- -20 °C · Store at -20°C
- Löslichkeit
- 100 · DMSO:100.0(Max Conc. mg/mL);91.13(Max Conc. mM)
- Aggregatzustand
- A crystalline solid
- Farbe
- White to off-white
- Stabilität
- Hygroscopic
- Major Application
- pharmaceutical (small molecule)
- InChIKey
- LKMMLHTWKLEARD-MGZQXKBQSA-N
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 2.4% (1 of 41) of reports.
Danger
H302 (92.7%): Harmful if swallowed [Warning Acute toxicity, oral]
P260, P261, P264, P270, P271, P273, P301+P317, P304+P340, P317, P319, P330, P391, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 41 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Regulatory InformationMilbemycin oxime: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazard Classes and CategoriesAcute Tox. 4 (92.7%)
Sicherheitsdaten
- wgk
- 3
- ridadr
- 2588
- hs_code
- 2932206000
- Toxizität
- LD50 orally in mice: 1000-1500 mg/kg (Ciba-Geigy)
- hazard_class
- 6.1(b)
- packing_group
- III
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Aquatic Acute 1Aquatic Chronic 1
Chemie und Industrie
Pharmakologische Informationen
ATC CodeQP - Antiparasitic products, insecticides and repellents
MeSH Pharmacological ClassificationAgents that kill parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.
Anwendungen
VerwendenMilbemycin oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of a mixture of two natural products, milbemycin A3 and A4 (in ~30:70 ratio). Milbemycin oxime is used therapeutically for the prevention of intestinal parasites in dogs. Like the other milbemycin/avermectins, it was developed for intestinal parasite control in animals and acts by opening glutamate sensitive chloride channels in neurons of invertebrates leading to paralysis by hyperpolarisation of these cells and signal transfer blocking.
Vor- und nachgelagerte Produkte
Vorgelagerte Rohstoffe
Anbieter100 Anbieter
国药集团化学试剂有限公司86-21-63210123 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]
苏州法姆医药科技有限公司
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