HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Levopropoxyphene
HSDB 3414 · l-Propoxyphene · Levopropossifene · levopropoxyphene · Levopropoxyphenum · levopropoxyphene USP/EP/BP · (1R,2S)-1-benzyl-3-dimethylamino-2-methyl-1-phenylpropyl propionate · (1R,2S)-3-(Dimethylamino)-2-methyl-1-phenyl-1-(phenylmethyl)propyl propanoate
Identifikatoren & physikalische Daten
| CAS No. | 2338-37-6 |
|---|---|
| Summenformel | C22H29NO2 |
| Durchschnittliche Molmasse | 339,5 g/mol |
| Monoisotopische Masse | 339,21982917 g/mol |
| SMILES | CCC(=O)O[C@@](Cc1ccccc1)(c1ccccc1)[C@@H](C)CN(C)C |
| InChIKey | XLMALTXPSGQGBX-PGRDOPGGSA-N |
| PubChem CID | 200742 |
| ChEMBL | CHEMBL1738990 |
| ChEBI | CHEBI:51174 |
| DTXSID | DTXSID8023212 |
Chemische & physikalische Eigenschaften
| XLogP | 4,2 |
|---|---|
| Polarare Oberfläche (TPSA) | 29,5 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 3 |
| Frei drehbare Bindungen | 9 |
| Schwere Atome | 25 |
| Formalladung | 0 |
| Komplexität | 397 |
| Arzneimittel | Pharmaceuticals -> Listed in ZINC15 |
| LogP (Verteilungskoeffizient) | 4.81 |
| Color/Form | CRYSTALS FROM PETROLEUM ETHER |
| Löslichkeit | SOL IN METHANOL, ALC, CHLOROFORM, & ACETONEVERY SOL IN WATER /NAPSYLATE/ |
| Schmelzpunkt | 75-76ºC75-76 °CMP: 163-164 °CSPECIFIC OPTICAL ROTATION: -60.1 DEG @ 25 °C/D (0.7%)/HYDROCHLORIDE/75-76° |
| Optical Rotation | SPECIFIC OPTICAL ROTATION: -68.2 DEG @ 25 °C/D (CHLOROFORM, 0.6%) |
| Stability/Shelf Life | PERMITS MORE STABLE LIQ & TABLET DOSAGE FORMS /NAPSYLATE/ |
| Other Experimental Properties | ESSENTIALLY ODORLESS & HAS BITTER TASTEMELTS WITHIN RANGE OF 4 DEG BETWEEN 158 & 165 °C /NAPSYLATE/CRYSTALS FROM METHANOL PLUS ETHYL ACETATE /HYDROCHLORIDE/WHITE POWDER /NAPSYLATE/ |
| Siedepunkt | 444.0±45.0 °C(Predicted) |
| Dichte | 1.038±0.06 g/cm3(Predicted) |
| pKa (Säurekonstante) | 9.19±0.28(Predicted) |
Sicherheit & Vorschriften
| Wechselwirkungen | THE ANALGESIA PRODUCED BY ORAL ADMIN OF D-PROPOXYPHENE IS ENHANCED BY INITIAL LOADING WITH L-PROPOXYPHENE. |
|---|---|
| Human Toxicity Excerpts | UNTOWARD EFFECTS ARE USUALLY MILDHEADACHE, LIGHT-HEADINESS, SKIN RASH, DRYNESS OF MOUTH, NAUSEA & VOMITING, URINARY URGENCY, & TREMORS HAVE BEEN REPORTED. /NAPSYLATE/SIDE EFFECTS OF LEVOPROPOXYPHENE INCL...URTICARIA, DROWSINESS...& DIZZINESS. /NAPSYLATE/ |
| Non-Human Toxicity Excerpts | L-PROPOXYPHENE-HCL (225 MG/KG, SC) DECREASED NORADRENALINE LEVELS IN BRAINS OF MICE. |
| Gefahrstoffdaten | 2338-37-6(Hazardous Substances Data) |
Anwendungen & Verwendung
Verwenden
Antitussive.