Selenocystine
Grundinformationen
- CAS
29621-88-3- Standard-SMILES
N[C@@H](C[Se][Se]C[C@H](N)C(=O)O)C(=O)O- InChIKey
JULROCUWKLNBSN-IMJSIDKUSA-N- Summenformel
- C6H12N2O4Se2
- Durchschnittliche Molmasse
- 334,11 g/mol
- Monoisotopische Masse
- 335,91274946
Überblick
RN given refers to parent cpd; structure
Namen und Bezeichner
- Bevorzugter Name
- Selenocystine
- IUPAC
- (2R)-2-amino-3-[[(2R)-2-amino-2-carboxyethyl]diselanyl]propanoic acid
- Englischer Name
- L-SELENOCYSTINE
- Summenformel
- C6H12N2O4Se2
- Molmasse
- 334.09
Namen und Synonyme
1464-43-3CHEBI:28553RefChem:8848323,3'-diselane-1,2-diylbis(2-aminopropanoic acid)3,3'-Diselenobisalanine3,3'-DiselenodialanineSelenocystineL-Selenocystine29621-88-3Seleno-L-cystineSelenocystine, L-C6H12N2O4Se2
Weitere Namen anzeigen
H-Se-Cystine-OHL-SELENOCYSTINE 98%L-Selenocystine,98%Seleno-L-cystine 95%3’-diselenodi-l-alanin3,3'-DISELENO-L-ALANINEl-3,3’-diselenodialanine
L-3,3'-DiselenodialanineAlanine, 3,3'-diselenodi-, L-(2R,2'R)-3,3'-diselanediylbis(2-aminopropanoic acid)MFCD00800971261B157KR83,3'-Diselenobis[L-alanine]L-Selenocystine Preparation Kit(2R)-2-amino-3-[[(2R)-2-amino-2-carboxyethyl]diselanyl]propanoic acid
Datenbank-Bezeichner
- CAS
29621-88-3- PubChem CID
- 207306
- DTXSID
DTXSID001044310- ChEMBL
CHEMBL5283716
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 127 Ų
- H-Brücken-Donoren
- 4
- H-Brücken-Akzeptoren
- 6
- Frei drehbare Bindungen
- 7
- Schwere Atome
- 14
- Formalladung
- 0
- Komplexität
- 192
Physikochemische Eigenschaften
- Schmelzpunkt
- 224.5 · 224.5-229.5 °C (lit.)
- Siedepunkt
- 538.3 · 538.3±60.0 °C(Predicted)
- storage temp.
- 2 · 2-8°C
- Löslichkeit
- Aqueous Acid (Slightly), Aqueous Base (Slightly)
- pka
- 1.69 · 1.69±0.10(Predicted)
- Aggregatzustand
- Powder
- Farbe
- Yellow
- BRN
- 1969559 · 1969559
- Stabilität
- Hygroscopic
- Major Application
- peptide synthesis
- InChI
- 1S/C6H12N2O4Se2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
- InChIKey
- JULROCUWKLNBSN-IMJSIDKUSA-N
- SMILES
- N[C@@H](C[Se][Se]C[C@H](N)C(O)=O)C(O)=O
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P260, P261, P264, P270, P271, P273, P301+P316, P304+P340, P316, P319, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 41 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 3 (100%)
Sicherheitsdaten
- wgk
- 3
- ridadr
- UN 3283 6.1/PG 3
- hs_code
- 29319090
- RTECS-Nr.
- AY6032000
- risk_code
- 23/25-33-50/53
- hazard_code
- T,N
- safety_code
- 20/21-28-45-60-61
- hazard_class
- 6.1
- packing_group
- III
- Speicherklasse
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- Hazard Classifications
- Acute Tox. 3 InhalationAcute Tox. 3 OralAquatic Acute 1Aquatic Chronic 1STOT RE 2
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Anwendungen
BeschreibungL-Selenocystine is a diselenide-bridged amino acid that may be confused with selenocysteine (Sec), which is a rare amino acid featuring a single selenium atom. L-Selenocystine is a redox-active selenium compound that has both anti- and pro-oxidant actions. This compound can be reduced by low molecular thiols and disulfide reductases to Sec. It is reduced to Sec by mammalian thioredoxin reductase (apparent Km = 6.0 μM), and this property can be used to assay thioredoxin reductase activity. L-Selenocystine induces an unfolded protein response, ER stress, and large cytoplasmic vacuolization in HeLa cells and has cytostatic effects in a range of cancer cell types.
VerwendenSeleno-L-cystine can be used for the synthesis of:Biologically active selenol compounds.Non-natural selenylated diamino acids.
Anbieter100 Anbieter
国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
郑州阿尔法化工有限公司+86-18530059196 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
湖南韵邦生物科技股份有限公司
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