Carbenicillin

Pyocianil · onamic acid · ARBENICILLIN · CARBENICILLIN · Carboxybenzylpenicillin · CARBENICILLIN USP/EP/BP · Lactic Acid Impurity 53 · CARBENICILLIN READY MADE

https://huagongshe.com/de/chemical/20824

Identifikatoren & physikalische Daten

CAS No.	4697-36-3
Summenformel	C17H18N2O6S
Durchschnittliche Molmasse	378,4 g/mol
Monoisotopische Masse	378,08855747 g/mol
SMILES	CC1(C)S[C@@H]2[C@H](NC(=O)C(C(=O)O)c3ccccc3)C(=O)N2[C@H]1C(=O)O
InChIKey	FPPNZSSZRUTDAP-UWFZAAFLSA-N
PubChem CID	20824
ChEMBL	CHEMBL1214
ChEBI	CHEBI:3393
EC No.	225-171-0
DTXSID	DTXSID6048464
Lokaler Name	Carbenicillin

Chemische & physikalische Eigenschaften

XLogP	1,1
Polarare Oberfläche (TPSA)	149
H-Brücken-Donoren	3
H-Brücken-Akzeptoren	7
Frei drehbare Bindungen	5
Schwere Atome	26
Formalladung	0
Komplexität	645
pH	PH: (1% SOLN, WT/VOL) BETWEEN 6.8 & 7.5
LogP (Verteilungskoeffizient)	1.13logP = 1.131.8
Löslichkeit	451WHITE TO OFF-WHITE, CRYSTALLINE POWDERBITTER TASTEHYGROSCOPICODORLESSPKA1: 2.76PKA2: 3.5SPECIFIC OPTICAL ROTATION: +175 TO +185 DEG1 G SOL IN 1.2 ML WATER, 25 ML ALCOHOLSOL IN METHANOL, DIL ALKALI, DIL ACIDINSOL IN ACETONE, CHLOROFORM, ETHER /DISODIUM/3.90e-01 g/LSoluble in DMSOH2O: 100mg/mLethanol: 100mg/mL
Physical Description	Solid
Stability/Shelf Life	UNSTABLE IN ACID /DISODIUM/Extended-spectrum penicillins are generally stable for several yr in the dry state @ room temphowever, the drugs are stable only for short periods of time in soln unless frozen. Like other penicillins, stability of extended-spectrum penicillins is pH and temp dependent ... carbenicillin indanyl sodium is more resistant to acid-catalyzed hydrolysis than carbenicillin and is generally stable in the presence of acidic gastric secretions following oral admin.
Siedepunkt	737.8±60.0 °C(Predicted)
Dichte	1.53±0.1 g/cm3(Predicted)
Lagerbedingungen	−20°C
Aggregatzustand	Powder
pKa (Säurekonstante)	pKa 2.22±0.05(H2O t = 25.0 I = 0.15 (KCl)) (Uncertain)3.25±0.02 (Uncertain)
InChIKey	FPPNZSSZRUTDAP-UWFZAAFLSA-N
SMILES	CC1(C)S[C@@H]2[C@H](NC(=O)C(C(O)=O)c3ccccc3)C(=O)N2[C@H]1C(O)=O
CAS Datenbank	4697-36-3

Sicherheit & Vorschriften

GHS-Einstufung	DangerH317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]H334 (100%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 39 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Regulatorische Informationen	Status: Active Update: 10-11-2008 https://echa.europa.eu/registration-dossier/-/registered-dossier/3229
Weitere Sicherheitsinformationen	IMAP assessments - 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(carboxyphenylacetyl)amino]-3,3-dimethyl-7-oxo-, [2S-(2.alpha.,5.alpha.,6.beta.)]-: Environment tier I assessmentIMAP assessments - 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(carboxyphenylacetyl)amino]-3,3-dimethyl-7-oxo-, [2S-(2.alpha.,5.alpha.,6.beta.)]-: Human health tier I assessment
FDA-Anforderungen	Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended21 U.S.C. 321-392).
Hazard Classes and Categories	Skin Sens. 1 (100%)Resp. Sens. 1 (100%)
Lagerbedingungen	Carbenicillin indanyl sodium tablets should be protected from moisture and stored in tight containers at a temperature not exceeding 30 °C. /Carbenicillin indanyl sodium/
Entsorgungsverfahren	SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Anwendungen & Verwendung

Verwenden

Antibacterial.