Amosulalol
Grundinformationen
- CAS
85320-68-9- Standard-SMILES
COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1- InChIKey
LVEXHFZHOIWIIP-UHFFFAOYSA-N- Summenformel
- C18H24N2O5S
- Durchschnittliche Molmasse
- 380,5 g/mol
- Monoisotopische Masse
- 380,14059304
Überblick
Amosulalol is a sulfonamide.
Namen und Bezeichner
- Bevorzugter Name
- Amosulalol
- IUPAC
- 5-[1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl]-2-methylbenzenesulfonamide
- Englischer Name
- Amosulalol
- Summenformel
- C18H24N2O5S
- Molmasse
- 380.46
Namen und Synonyme
Amosulalol85320-68-9AmosulalolumC69JI1BAU8DTXSID908688935-(1-hydroxy-2-((2-(2-methoxyphenoxy)ethyl)amino)ethyl)-2-methylbenzenesulfonamide5-[1-Hydroxy-2-[[2-(2-methoxyphenoxy)ethyl]amino]ethyl]-2-methylbenzenesulfonamideRefChem:112259DTXCID50816951Amosulalol [INN]5-[1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl]-2-methylbenzenesulfonamideAmosulalol (INN)
Weitere Namen anzeigen
Amosulalol USP/EP/BPAmosulalol, 10 mM in DMSOBenzenesulfonamide, 5-[1-hydroxy-2-[[2-(2-methoxyphenoxy)ethyl]amino]ethyl]-2-methyl-Benzenesulfonamide, 5-[1-hydroxy-2-[[2-(2-methoxyphenoxy)ethyl]amino]ethyl]-2-methyl-, (+-)-
(+-)-5-(1-Hydroxy-2-((2-(o-methoxyphenoxy)ethyl)amino)ethyl)-o-toluenesulfonamideAmosulalolum [Latin]UNII-C69JI1BAU8AMOSULALOL [MI]5-[1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl]-2-methyl-benzenesulfonamideAMOSULALOL [WHO-DD]SCHEMBL48933CHEMBL152231
Datenbank-Bezeichner
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 1,2
- Polarare Oberfläche (TPSA)
- 119 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 7
- Frei drehbare Bindungen
- 9
- Schwere Atome
- 26
- Formalladung
- 0
- Komplexität
- 510
Physikochemische Eigenschaften
- Aggregatzustand
- Solid
- Farbe
- White to off-white
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Anwendungen
BeschreibungAmosulalol is a potent antihypertensive with combined alpha and beta blocking properties. Indicated for the treatment of essential hypertension, it appears to possess a minimum of side-effects. Its beta-blocking property reduces the tachycardia associated with alpha-blockers, while its alpha-blocking activity reduces the peripheral vasoconstriction associated with beta-blockade.
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