Disodium 2-hydroxypentanedioate
Grundinformationen
- CAS
40951-21-1- Standard-SMILES
O=C([O-])CCC(O)C(=O)[O-].[Na+].[Na+]- InChIKey
DZHFTEDSQFPDPP-UHFFFAOYSA-L- Summenformel
- C5H6Na2O5
- Durchschnittliche Molmasse
- 192,08 g/mol
- Monoisotopische Masse
- 192,00106185
Überblick
Disodium 2-hydroxypentanedioate is an organic molecular entity.
Namen und Bezeichner
- Bevorzugter Name
- Disodium 2-hydroxypentanedioate
- IUPAC
- disodium;2-hydroxypentanedioate
- Englischer Name
- 2-hydroxypentanedioic acid
- Summenformel
- C5H9NaO5
- Molmasse
- 172.11
Namen und Synonyme
disodium 2-hydroxypentanedioateDTXSID00961324RefChem:1083838DTXCID70138915540951-21-1disodium;2-hydroxypentanedioate2-Hydroxypentanedioic acid sodium saltD-2-Hydroxypentanedioic acid disodium saltMFCD03939807Sodium 2-Hydroxypentanedioate2-Hydroxyglutaric Acid Disodium Salt, contains up to 10% Methanol2-Hydroxyglutaric acid disodium salt
Weitere Namen anzeigen
2-HG (sodium salt)Disodium 2-hydroxyglutarateα-Hydroxyglutaric acid (sodium)2-Hydroxyglutaric Acid Disodiumα-Hydroxyglutaric acid (disodium)2-Hydroxyglutaric Acid (sodium salt)DL-ALPHA-HYDROXYGLUTARIC ACID DISODIα-Hydroxyglutaric Acid (sodium salt)
(Rs)-2-hydroxypentanedioic acid disodium saltPentanedioic acid,2-hydroxy-, sodium salt (1:2)Disodium (R)-2-Hydroxyglutaratealpha-Oxyglutarate sodium2-Hydroxyglutaric Acid Disodium Salt, contains up to 10per cent MethanolSodium alpha-hydroxyglutarate2-Hydroxyglutaric acid sodium saltD-2-Hydroxypentanedioic acid-2Na+
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 100 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 5
- Frei drehbare Bindungen
- 2
- Schwere Atome
- 12
- Formalladung
- 0
- Komplexität
- 130
Physikochemische Eigenschaften
- Schmelzpunkt
- 290 C · >290C (dec.)
- storage temp.
- 2 · 2-8°C 2-8°C
- Löslichkeit
- Methanol (Slightly), Water (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Wasserlöslichkeit
- 100 mM · Soluble to 100 mM in water
- InChI
- 1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2
- InChIKey
- DZHFTEDSQFPDPP-UHFFFAOYSA-L
- SMILES
- [Na+].[Na+].OC(CCC([O-])=O)C([O-])=O
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- Speicherklasse
- 11 - Combustible Solids
Chemie und Industrie
Anwendungen
Beschreibungα-Hydroxyglutaric acid (2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases, and mutations in these enzymes lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased levels of L-2-hydroxyglutaric acid . 2-HG can also be metabolized from isocitrate by mutated forms of isocitrate dehydrogenase 1 (IDH1) and IDH2. 2-HG is structurally similar to α-ketoglutarate, the product of wild-type isocitrate dehydrogenases, and competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone lysine demethylases and DNA hydroxylases.
Verwenden2-Hydroxyglutaric acid is a potential inhibitor of glutamate carboxypeptidase.
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