Dronedarone Hydrochloride
Dronedarone HCl · Dronedarone hydrochloride, ≥98% (HPLC) · Multaq · CS-132 · SR33589 · SR-33589B · CAS:141625-93-6 · DRONEDARONE HCl CAS:
Identifikatoren & physikalische Daten
| CAS No. | 141625-93-6 |
|---|---|
| Summenformel | C31H45ClN2O5S |
| Durchschnittliche Molmasse | 593,2 g/mol |
| Monoisotopische Masse | 592,27377122 g/mol |
| SMILES | CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1.Cl |
| InChIKey | DWKVCQXJYURSIQ-UHFFFAOYSA-N |
| PubChem CID | 219025 |
| ChEMBL | CHEMBL1201729 |
| EC No. | 630-355-2 |
| DTXSID | DTXSID30161779 |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 97,2 |
|---|---|
| H-Brücken-Donoren | 2 |
| H-Brücken-Akzeptoren | 7 |
| Frei drehbare Bindungen | 18 |
| Schwere Atome | 40 |
| Formalladung | 0 |
| Komplexität | 800 |
| Human Drugs | FDA approved drugs -> Active ingredient |
| Schmelzpunkt | NA (low-melting) |
| Lagerbedingungen | 2-8°C |
| Löslichkeit | DMSO: soluble15mg/mL, clear |
| Aggregatzustand | powder |
| Farbe | white to off-white |
| Merck | 14,3449 |
| Stabilität | Hygroscopic |
| InChIKey | DWKVCQXJYURSIQ-UHFFFAOYSA-N |
| SMILES | Cl.CCCCN(CCCC)CCCOc1ccc(cc1)C(=O)c2c(CCCC)oc3ccc(NS(C)(=O)=O)cc23 |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 8.3% (1 of 12) of reports.WarningH302 (33.3%): Harmful if swallowed [Warning Acute toxicity, oral]P203, P260, P261, P263, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 12 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Hazard Classes and Categories | Acute Tox. 4 (33.3%) |
| Drug Induced Liver Injury | Drug Induced Liver Injury Rank (DILIrank 2.0)Dronedarone hydrochloridevMost-DILI-concern7Warnings & precautionsDOI:10.1016/j.drudis.2016.02.015 |
| Wassergefährdungsklasse (WGK) | 3 |
| UN-Transportnummer | UN 3077 9 / PGIII |
| Zollcode | 2935904000 |
| Lagerklasse | 11 - Combustible Solids |
Anwendungen & Verwendung
History
DRONEDARONE HYDROCHLORIDE (brand name: Multaq) is an antiarrhythmic drug developed by Sanofi-Aventis. It was approved by the FDA in July 2009 for the treatment of atrial fibrillation and atrial flutter, reducing the risk of cardiovascular hospitalization in patients with paroxysmal or persistent atrial fibrillation (AF) or atrial flutter (AFL). The drug was developed to create a treatment that maintains the therapeutic benefits of amiodarone while reducing associated serious side effects such as pulmonary toxicity and thyroid dysfunction. DRONEDARONE HYDROCHLORIDE is usually administered orally in tablet form. The recommended dose is 400 mg twice daily, one tablet in the morning and one in the evening.
Verwenden
Dronedarone Hydrochloride can be used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.