Phenoxodiol
Grundinformationen
- CAS
81267-65-4- Standard-SMILES
Oc1ccc(C2=Cc3ccc(O)cc3OC2)cc1- InChIKey
ZZUBHVMHNVYXRR-UHFFFAOYSA-N- Summenformel
- C15H12O3
- Durchschnittliche Molmasse
- 240,25 g/mol
- Monoisotopische Masse
- 240,07864424
Überblick
Idronoxil is a substance that is being studied in the treatment of cancer. It belongs to the family of drugs called signal transduction inhibitors.
Namen und Bezeichner
- Bevorzugter Name
- Phenoxodiol
- IUPAC
- 3-(4-hydroxyphenyl)-2H-chromen-7-ol
- Englischer Name
- Phenoxodiol
- Summenformel
- C15H12O3
- Molmasse
- 240.25
Namen und Synonyme
PhenoxodiolIdronoxil81267-65-43-(4-Hydroxyphenyl)-2H-chromen-7-ol3-(4-Hydroxyphenyl)-2H-1-benzopyran-7-olNV-062H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-Idronoxilo7-hydroxy-3-hydroxyphenyl-1H-benzopyran995FT1W541DTXSID50231029idronoxilum
Weitere Namen anzeigen
NV 06Idronoxil，PhenoxodiolPhenoxodiol, 10 mM in DMSO7,4'-DIHYDROXYISOFLAV-3-ENEPhenoxodiol Haginin E Idronoxil
2H-1-benzopyran-7-0,1,3-(4-hydroxyphenyl)RefChem:790571NOX66DTXCID00153520663-523-9DehydroequolHaginin EPhenoxodiol (Haginin E)
Datenbank-Bezeichner
- CAS
81267-65-4- PubChem CID
- 219100
- DTXSID
DTXSID50231029- ChEMBL
CHEMBL1957038- UNII
- 995FT1W541
- EC Number
- 663-523-9
- Nikkaji
- J1.174.680B
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2,7
- Polarare Oberfläche (TPSA)
- 49,7 Ų
- H-Brücken-Donoren
- 2
- H-Brücken-Akzeptoren
- 3
- Frei drehbare Bindungen
- 1
- Schwere Atome
- 18
- Formalladung
- 0
- Komplexität
- 318
Experimentelle und physikochemische Eigenschaften
DrugsPharmaceuticals -> Listed in ZINC15
SpringerMaterials Properties13C nuclear magnetic resonance spectrum
Endocrine DisruptorsPotential endocrine disrupting compound
Physikochemische Eigenschaften
- storage temp.
- room temp
- Löslichkeit
- 10 mg/mL, · DMSO: soluble10mg/mL, clear
- Aggregatzustand
- powder
- Farbe
- white to light brown
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P273, P301+P317, P330, P391, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 39 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Sicherheitsdaten
- wgk
- 3
- ridadr
- UN 3077 9 / PGIII
- risk_code
- 22-50
- hazard_code
- Xn,N
- safety_code
- 61
Chemie und Industrie
Pharmakologische Informationen
Pharmacodynamics
Phenoxodiol inhibits proliferation of many cancer cell lines and induces apoptosis by disrupting FLICE-inhibitory protein, FLIP, expression and by caspase-dependent and -independent degradation of the X-linked inhibitor of apoptosis, XIAP. In addition, phenoxodiol sensitizes drug-resistant tumour cells to anticancer drugs including paclitaxel, carboplatin and gemcitabine.
Mechanism of Action
The antiproliferative effects of phenoxodiol are associated with inhibition of plasma membrane electron transport in tumour cell lines and primary immune cells. Results from one study (PMID: 17904534) indicate that plasma membrane electron transport (PMET) may be a primary target for phenoxodiol in tumour cells and in activated T cells.
Anwendungen
VerwendenAntineoplastic which acts as an antiproliferative, topoisomerase II inhibitor; 5 reductase inhibitor[Note— The trivial name, phenoxodiol, has appeared in literature].
Anbieter65 Anbieter
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
武汉众志诚生物技术有限公司
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