2-Amino-4-phosphonobutanoic acid
Grundinformationen
- CAS
20263-07-4- Standard-SMILES
NC(CCP(=O)(O)O)C(=O)O- InChIKey
DDOQBQRIEWHWBT-UHFFFAOYSA-N- Summenformel
- C4H10NO5P
- Durchschnittliche Molmasse
- 183,1 g/mol
- Monoisotopische Masse
- 183,02965942
Überblick
glutamate antagonist in locust muscle; structure; do not confuse with L-AP4, which is the propionic acid version
Namen und Bezeichner
- Bevorzugter Name
- 2-Amino-4-phosphonobutanoic acid
- IUPAC
- 2-amino-4-phosphonobutanoic acid
- Englischer Name
- 2-amino-4-phosphonobutyric acid
- Summenformel
- C4H10NO5P
- Molmasse
- 183.1
Namen und Synonyme
2-amino-4-phosphonobutanoic acid6323-99-52-Amino-4-phosphonobutyric acidButanoic acid, 2-amino-4-phosphono-BUTYRIC ACID, 2-AMINO-4-PHOSPHONO-H8B59H10OKDTXSID201017567NSC-30079NSC-354086Abu(P)DL-2-amino-4-phosphobutanoic acidRefChem:464373
Weitere Namen anzeigen
DL-2-Amino-4-phosphonobutyric Acid, 98.0+ % (HPLC)
DTXCID901451615DL-AP420263-07-4DL-2-Amino-4-phosphonobutyric acidap-4(+/-)-2-Amino-4-phosphonobutyric acidNSC30079DL-2-Amino-4-phosphonobutanoic acid (AP4)
Datenbank-Bezeichner
- CAS
20263-07-4、6323-99-5- PubChem CID
- 2207
- DTXSID
DTXSID201017567- ChEMBL
CHEMBL285843- UNII
- H8B59H10OK
- EC Number
- 622-387-0
- Nikkaji
- J327.345H
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- -5,5
- Polarare Oberfläche (TPSA)
- 121 Ų
- H-Brücken-Donoren
- 4
- H-Brücken-Akzeptoren
- 6
- Frei drehbare Bindungen
- 4
- Schwere Atome
- 11
- Formalladung
- 0
- Komplexität
- 187
Physikochemische Eigenschaften
- Schmelzpunkt
- 229 · 229-231 °C(Solv: ethanol (64-17-5); water (7732-18-5))
- Siedepunkt
- 491.7 · 491.7±55.0 °C(Predicted)
- Dichte
- 1.628 · 1.628±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- Löslichkeit
- 9.15 · Water:9.15(Max Conc. mg/mL);50.0(Max Conc. mM)
- Aggregatzustand
- White solid.
- pka
- 2.19 · 2.19±0.10(Predicted)
- Farbe
- White to off-white
- Wasserlöslichkeit
- 50 mM · Soluble to 50 mM in water
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
GHS-Klassifizierung
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 42 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Gefahrenhinweise
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
Chemie und Industrie
Pharmakologische Informationen
MeSH Pharmacological Classification
Drugs used to prevent SEIZURES or reduce their severity.
Drugs that bind to and activate excitatory amino acid receptors.
Anwendungen
BeschreibungDL-AP4 is a broad-spectrum glutamatergic antagonist. DL-AP4 (2.5 mM) inhibits electrically stimulated synaptic transmission in rabbit hippocampal slices. It also depresses depolarizations induced by NMDA , L-homocysteate, or kainate in isolated frog spinal cord when used at a concentration of 1 mM. DL-AP4 (0.2 mM) inhibits the accumulation of inositol induced by ibotenate , quisqualate, L-glutamate, and L-aspartate in rat hippocampal slices.
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陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
湖北永阔科技有限公司027-59223108 15972152991 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
上海迈瑞尔生化科技有限公司4006356688 18621169109 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
阿法埃莎（中国）化学有限公司400-6106006 · [email protected]
安耐吉化学&3A（安徽泽升科技股份有限公司）400-0056266 · [email protected]
MedBio脉铂医药
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