Glycinhydrochlorid
GLYCINE HCL · GLYCINE-HCL BUFFER · AMINOACETIC ACID HYDROCHLORIDE · Gly.HCL · h-gly-oh.hcl · ycine hydrochL · GLYCINE HYDROCHLORIDE · Amino-acetic acid HCl
Identifikatoren & physikalische Daten
| CAS No. | 6000-43-7 |
|---|---|
| Summenformel | C2H5NO2.ClH |
| Durchschnittliche Molmasse | 111,53 g/mol |
| Monoisotopische Masse | 111,00870611 g/mol |
| SMILES | Cl.NCC(=O)O |
| InChIKey | IVLXQGJVBGMLRR-UHFFFAOYSA-N |
| PubChem CID | 22316 |
| EC No. | 227-841-8 |
| DTXSID | DTXSID7064079 |
| Lokaler Name | Glycinhydrochlorid |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 63,3 |
|---|---|
| H-Brücken-Donoren | 3 |
| H-Brücken-Akzeptoren | 3 |
| Frei drehbare Bindungen | 1 |
| Schwere Atome | 6 |
| Formalladung | 0 |
| Komplexität | 42,9 |
| Stoffklassen | Biological Agents -> Amino Acids and Derivatives |
| Physical Description | Hygroscopic solid[Merck Index] White odorless crystalline powder[Alfa Aesar MSDS] |
| Schmelzpunkt | 176-180 °C(lit.) |
| Dichte | 1.457[at 20℃] |
| Dampfdruck | 0.003Pa at 20℃ |
| Lagerbedingungen | 2-8°C |
| Aggregatzustand | Crystalline Powder |
| Farbe | White to almost white |
| Biologische Quelle | synthetic |
| Löslichkeit | SLIGHTLY SOLUBLE |
| Merck | 14,4491 |
| BRN | 3909617 |
| Hauptanwendungen | food and beverages |
| Kosmetik-Inhaltsstoffe Funktionen | BUFFERING |
| InChI | InChI=1S/C2H5NO2.ClH/c3-1-2(4)5/h1,3H2,(H,4,5)1H |
| InChIKey | IVLXQGJVBGMLRR-UHFFFAOYSA-N |
| SMILES | C(=O)(O)CN.Cl |
| LogP (Verteilungskoeffizient) | -3.25 at 20℃ |
| CAS Datenbank | 6000-43-7(CAS DataBase Reference) |
| EPA chemische Informationen | Glycine, hydrochloride (6000-43-7) |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 33.3% (3 of 9) of reports.DangerH314 (33.3%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 9 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | Chemical: Glycine, hydrochlorideStatus: Active Update: 29-05-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/23884 |
| Weitere Sicherheitsinformationen | Evaluation - Chemicals that are unlikely to require further regulation to manage risks to environment |
| Gefahrenübersicht | Causes altered sleep time (including change in righting reflex), ataxia, and dyspnea in oral lethal-dose studies of rats[RTECS] May cause irritation[Alfa Aesar MSDS] See Glycine. |
| Hazard Classes and Categories | Skin Corr. 1B (33.3%) |
| F | 10 |
| Wassergefährdungsklasse (WGK) | 2 |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | UN 1789 8/PG 3 |
| Zollcode | 29224999 |
| RTECS-Nr. | MC0560000 |
| R-Sätze (R) | 22 |
| Sicherheitshinweise (S) | 24/25-44 |
| Lagerklasse | 8B - Non-combustible corrosive hazardous materials |
| Gefahrenklasse | Eye Irrit. 2Met. Corr. 1Skin Irrit. 2 |
Anwendungen & Verwendung
Verwenden
Glycine hydrochloride is an inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.Glycine Hydrochloride is commonly used in buffer solutions, in electrophoresis, and preparative chromatography.
Herstellung & Synthese
synthetische
Glycine hydrochloride can be prepared by the action of hydrochloric acid on hippuric acid,aminoacetonitrile,methyleneaminoacetonitrile, and on ethyl phthaliminoacetate. Aniline has been recommended for its conversion into free glycine. Glycine can also be prepared by the interaction of chloroacetic acid and ammonia; by the hydrolysis of methyleneaminoacetonitrile by successive treatments with barium hydroxide and sulfuric acid; and by the hydrolysis of aminoacetonitrile by means of barium hydroxide. A thorough study has been reported for its preparation in improved yields by the sulfuric acid hydrolysis of aminoacetonitrile, and in satisfactory yields from chloroacetic acid and ammonia. Other methods of preparation include the reduction of cyanoformic esters, a modified Curtius degradation of ethyl cyanoacetate, and the hydrolysis of the neck ligaments of cattle.synthesis of Glycine hydrochloride