Technetium (99mTc) sestamibi
Grundinformationen
- CAS
109581-73-9- Standard-SMILES
[C-]#[N+]CC(C)(C)OC.[C-]#[N+]CC(C)(C)OC.[C-]#[N+]CC(C)(C)OC.[C-]#[N+]CC(C)(C)OC.[C-]#[N+]CC(C)(C)OC.[C-]#[N+]CC(C)(C)OC.[Tc]- InChIKey
KNMLZCYLMYOYBD-UHFFFAOYSA-N- Summenformel
- C36H66N6O6Tc
- Durchschnittliche Molmasse
- 775,9 g/mol
- Monoisotopische Masse
- 775,41074
Überblick
Technetium Tc-99m sestamibi (commonly sestamibi) is a pharmaceutical agent used in nuclear medicine imaging. The drug is a coordination complex consisting of the radioisotope technetium-99m bound to six methoxyisobutylisonitrile (MIBI) ligands, hence the name sesta (6) MIBI.. Following intravenous injection of the drug, Technetium Tc-99m sestamibi is taken up by the myocardium, parathyroid, and/or breast tissue. The mechanism by which sestamibi localizes to these tissues has not been established. Single photon emission computed tomography (SPECT) is then performed to detect the gamma ray emmitted by the decay of Technetium-99m to Technetium-99. Currently available within a preparation kit for injection, Technetium Tc 99m Sestamibi is indicated for: 1) detecting coronary artery disease by localizing myocardial ischemia (reversible defects) and infarction (non-reversible defects); and 2) evaluating myocardial function and developing information for use in patient management decisions.
Namen und Bezeichner
- Bevorzugter Name
- Technetium (99mTc) sestamibi
- IUPAC
- hexakis(1-isocyano-2-methoxy-2-methylpropane);technetium
Namen und Synonyme
Technetium (99mTc) sestamibiSestamibiTechnetium Tc-99m sestamibi1-isocyano-2-methoxy-2-methylpropane;technetiumCardioliteTechnetium (99m Tc) sestamibiTechnetium Tc 99m sestamibi109581-73-999mTc Sestamibi99mTc Hexamibi99m Tc-sestamibi99m-Tc sestamibi
Weitere Namen anzeigen
SESTAMIBI [VANDF]SCHEMBL548709TC99M RP-30ATC99M-RP-30Atechnetium (mTc) sestamibi [INN]971Z4W1S09DB09161TECHNETIUM TC-99M SESTAMIBI KIT
Datenbank-Bezeichner
- CAS
109581-73-9- PubChem CID
- 22617237
- UNII
- 971Z4W1S09
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 81,5 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 12
- Frei drehbare Bindungen
- 12
- Schwere Atome
- 49
- Formalladung
- 0
- Komplexität
- 109
Chemie und Industrie
Pharmakologische Informationen
ATC Code
V - Various
QV - Various
Protein BindingThere is less than 1% protein binding of Technetium Tc 99m Sestamibi in plasma.
Biological Half-Life
Technetium Tc 99m decays by isomeric transition with a physical half-life of 6.02 hours. Blood clearance studies indicate that the fast clearing component clears with a t½ of 4.3 minutes at rest, and clears with a t½ of 1.6 minutes under exercise conditions. The myocardial biological half-life is approximately six hours after a rest or exercise injection. The biological half-life for the liver is approximately 30 minutes after a rest or exercise injection.
Metabolism/MetabolitesThe agent is excreted without any evidence of metabolism.
Absorption, Distribution and Excretion
At five minutes post injection about 8% of the injected dose remains in circulation. Myocardial uptake which is coronary flow dependent is 1.2% of the injected dose at rest and 1.5% of the injected dose at exercise.
The major pathway for clearance of Tc 99m Sestamibi is the hepatobiliary system. Activity from the gall bladder appears in the intestines within one hour of injection. Twenty-seven percent of the injected dose is excreted in the urine, and approximately thirty-three percent of the injected dose is cleared through the feces in 48 hours.
The effective half-life of clearance (which includes both the biological half-life and radionuclide decay) for the heart is approximately 3 hours, and for the liver is approximately 30 minutes, after a rest or exercise injection.
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