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Strychnidin-10-on-sulfat (2:1)

Strychnine sulfate

HCID 22833295
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Grundinformationen

CAS
60-41-3
Standard-SMILES
O=C1C[C@@H]2OCC=C3CN4CC[C@]56c7ccccc7N1[C@H]5[C@H]2[C@H]3C[C@H]46.O=C1C[C@@H]2OCC=C3CN4CC[C@]56c7ccccc7N1[C@H]5[C@H]2[C@H]3C[C@H]46.O=S(=O)(O)O
InChIKey
GOOCRIHPADOQAS-ZNUXJMJHSA-N
Summenformel
C42H46N4O8S
Durchschnittliche Molmasse
766,9 g/mol
Monoisotopische Masse
766,30363561

Überblick

Strychnine sulfate appears as colorless, odorless, very bitter crystals or white crystalline powder. Has been used as a tonic and stimulant in veterinary medicine. Registered as a rodenticide in the U.S. (EPA, 1998)

Namen und Bezeichner

Bevorzugter Name
Strychnine sulfate
IUPAC
bis((4aR,5aS,8aR,13aS,15aS,15bR)-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one);sulfuric acid
Lokaler Name
Strychnidin-10-on-sulfat (2:1)
Englischer Name
Strychnine Sulfate
Summenformel
C21H22N2O2.1/2H2O4S
Molmasse
766.91

Namen und Synonyme

Strychnine sulfate60-41-3Strychnine hemisulphate saltAntivampireVampirolSTRYCHNINE SULPHATEStrychinium sulfateCaswell No. 806Strychnine, sulfate (2:1)Strychnine, sulfateStrychnine, sulphate (2:1)DTXSID8021721
Weitere Namen anzeigen
STRYCHNINE SULFATE HYDRATEL-STRYCHNINEstrychiniumsulfateSTRYCHNINE ALKALOIDSTRYCHNINE HEMISULFATEStrychnine Sulfate BPC
Strychnine sulfate [NF]UNII-FA486DV76SEPA Pesticide Chemical Code 076902FA486DV76SEINECS 200-477-7DTXCID501721STRYCHNINE SULFATE [MI]STRYCHNINE SULFATE [VANDF]

Datenbank-Bezeichner

CAS
60-41-3
PubChem CID
22833295
DTXSID
DTXSID8021721
ChEMBL
CHEMBL2103753
ChEBI
CHEBI:233239
UNII
FA486DV76S
EC Number
200-477-7

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
149 Ų
H-Brücken-Donoren
2
H-Brücken-Akzeptoren
10
Frei drehbare Bindungen
0
Schwere Atome
55
Formalladung
0
Komplexität
771

Experimentelle und physikochemische Eigenschaften

Density1.36 @ 20°C
SolubilitySolubility in water, g/100ml: 2.9
Decomposition~200 °C
Melting Point · 2 Einträge

392 °F with decomposition (EPA, 1998)

200 °C

Vapor Pressure0.00000001 [mm Hg] @25 °C
Physical Description · 2 Einträge

Strychnine sulfate appears as colorless, odorless, very bitter crystals or white crystalline powder. Has been used as a tonic and stimulant in veterinary medicine. Registered as a rodenticide in the U.S. (EPA, 1998)

ODOURLESS COLOURLESS CRYSTALS OR WHITE CRYSTALLINE POWDER WITH BITTER TASTE.

Physikochemische Eigenschaften

Schmelzpunkt
284 · 284-286 °C(lit.)
Dichte
1.0926 · 1.0926 (rough estimate)
Brechungsindex
1.6 · 1.6000 (estimate)
Löslichkeit
chloroform: clear to hazy
Aggregatzustand
powder
pka
8.26 · 8.26(at 25℃)
Farbe
white to off-white
Geruch (Odor)
Odorless
Merck
8855 · 8855
InChIKey
GOOCRIHPADOQAS-ZNUXJMJHSA-N
CAS Datenbank
60 · 60-41-3(CAS DataBase Reference)
EPA chemische Informationen
Strychnine sulfate (60-41-3)

Sicherheit und Regulatorisches

Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.

GHS-Klassifizierung

GHS Classification · 4 Einträge

Danger

H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]

P260, P264, P270, P271, P273, P284, P301+P316, P304+P340, P316, P320, P321, P330, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 43 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

Regulatory Information · 2 Einträge

Strychnine sulphate: HSNO Approval: HSR007329 Approved with controls

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

DOT LabelPoison
Fire Hazards · 2 Einträge

When heated to decomposition, it emits very toxic fumes of sulfur oxides and nitrogen oxides. Avoid alkalies, alkali carbonates and bicarbonates, benzoates, dichromates, bromides, iodides, tannic and picric acids, salicylates, borax, gold chloride and other alkaloid precipitants, piperazine, potassium-mercuric iodide. Protect from light. (EPA, 1998)

Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.

Health HazardsViolent poison!. Lowest published lethal dose orally in humans is 30 mg/kg. (EPA, 1998)
Reactive GroupAmides and Imides
EC ClassificationSymbol: T+, N; R: 26/28-50/53; S: (1/2)-13-28-45-60-61; Note: A
UN ClassificationUN Hazard Class: 6.1; UN Pack Group: I
Reactivity ProfileSTRYCHNINE SULFATE is a salt of strychnine. Strychnine is an alkaloid derivative which forms water soluble salts with acids.
Chemical DangersDecomposes on heating. This produces toxic fumes including sulfur oxides and nitrogen oxides.
Packaging and LabellingDo not transport with food and feedstuffs. Marine pollutant.
Air and Water ReactionsNo rapid reaction with air. No rapid reaction with water.
Hazard Classes and CategoriesAcute Tox. 1 (100%)

Sicherheit und Schutzausrüstung

Fire Fighting · 2 Einträge

(Non-Specific -- Strychnine and Salts) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. Wear self-contained (positive pressure if available) breathing apparatus and full protective clothing.

In case of fire in the surroundings, use appropriate extinguishing media.

First Aid Measures · 4 Einträge

Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.

Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth. Refer for medical attention . Avoid unnecessary stimulation of the victim.

First AidWarning: Strychnine sulfate may induce convulsions within 15 to 60 minutes following exposure. Caution is advised. Vital signs should be monitored closely.
Safe StorageProvision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Well closed.
Nonfire Spill Response(Non-Specific -- Strychnine and Salts) Do not touch spilled material; stop leak if you can do it without risk.
Spillage Disposal · 1 Eintrag

Personal protection: self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Isolation and EvacuationExcerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:
Eye PreventionWear safety goggles.
Inhalation RiskEvaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.
Skin PreventionProtective gloves.
Exposure PreventionAVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!
Ingestion PreventionDo not eat, drink, or smoke during work. Wash hands before eating.

Toxikologische Informationen

Exposure RoutesThe substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
Signs and Symptoms · 2 Einträge

See Ingestion.

Convulsions. Muscle stiffness. Shock or collapse.

ICSC Environmental Data · 1 Eintrag

The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to birds. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.

Sicherheitsdaten

wgk
3
ridadr
UN 1692 6.1/PG 1
RTECS-Nr.
WL2550000
risk_code
27/28-50/53-26/28
Toxizität
LD50 orally in rats: 5 mg/kg, E. W. Schafer, Toxicol. Appl. Pharmacol. 21, 315 (1972)
hazard_code
T+,N
safety_code
36/37-45-60-61-28-13
hazard_class
6.1(a)
packing_group
I
Speicherklasse
6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
Hazard Classifications
Acute Tox. 1 OralAcute Tox. 2 InhalationAquatic Acute 1Aquatic Chronic 1

Chemie und Industrie

Anwendungen

Verwendencentral stimulant

Anbieter28 Anbieter

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