Polyoxyethylene sorbitan monostearate
Grundinformationen
- CAS
9005-67-8- Standard-SMILES
CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](OCCO)[C@H]1OCCO- InChIKey
CRBBOOXGHMTWOC-NPDDRXJXSA-N- Summenformel
- C22H42O8
- Durchschnittliche Molmasse
- 434,6 g/mol
- Monoisotopische Masse
- 434,28796829
Überblick
1,4-Anhydro-6-O-dodecanoyl-2,3-bis-O-(2-hydroxyethyl)-D-glucitol is a fatty acid ester.
Namen und Bezeichner
- Bevorzugter Name
- Polyoxyethylene sorbitan monostearate
- IUPAC
- [(2R)-2-[(2R,3R,4S)-3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-hydroxyethyl] dodecanoate
- Englischer Name
- Tween 60
- Summenformel
- C64H126O26
- Molmasse
- 0
Namen und Synonyme
(2R)-2-[(2R,3R,4S)-3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-hydroxyethyl dodecanoateDTXSID9029300Polysorbata 60(2R)-2-((2R,3R,4S)-3,4-bis(2-hydroxyethoxy)oxolan-2-yl)-2-hydroxyethyl dodecanoateRefChem:1096504PEG-20 sorbitan palmitostearateINS-435E-435Polyoxyethylene 20 sorbitan monopalmitostearatePolyoxyethylene(20)sorbitan monopalmitostearate618-984-0CAL22UVI4M
Weitere Namen anzeigen
POLYSORBATE 60POLYOXYETHYLENE (20) SORBITAN MONOSTEARATETween 60, CPPolysorbat 60POLYOXYETHYLENE SORBITAN MONOSTEARATET-61PolysoFEMA 2916TWEEN(R) 60POLYETHYLENE GLYCOL SORBITAN MONOSTEARATE
CHEBI:53425FEMA No. 2916PEG sorbitan stearateSorbimacrogol stearate 300[(2R)-2-[(2R,3R,4S)-3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-hydroxyethyl] dodecanoateSorbomacrogol stearate 300Tween? 60DSSTox_CID_9300
Eigenschaften
Berechnete Struktureigenschaften
- XLogP
- 2,8
- Polarare Oberfläche (TPSA)
- 115 Ų
- H-Brücken-Donoren
- 3
- H-Brücken-Akzeptoren
- 8
- Frei drehbare Bindungen
- 20
- Schwere Atome
- 30
- Formalladung
- 0
- Komplexität
- 420
Experimentelle und physikochemische Eigenschaften
PolymersOther Classes -> Polyoxyethylenes
CosmeticsCosmetic ingredients (Polysorbate 60) -> CIR (Cosmetic Ingredient Review)
FragrancesFragrance Ingredient (Polysorbate 60) -> IFRA transparency List
Food AdditivesBOILER WATER ADDITIVE, EMULSIFIER OR EMULSIFIER SALT, FLAVORING AGENT OR ADJUVANT, STABILIZER OR THICKENER, SURFACE-ACTIVE AGENT -> FDA Substance added to food
Food Contact SubstancesFCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR
Physical Description
Dark yellow opaque viscous liquid; [Sigma-Aldrich MSDS]
Liquid
Physikochemische Eigenschaften
- Schmelzpunkt
- 23 °C · 23 °C
- Siedepunkt
- 802.68 °C · 802.68°C (rough estimate)
- Dichte
- 1.1 g/cm · 1.1 g/cm 3 at 20 °C
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Gefahrenhinweise
Regulatory Information
Chemical: Sorbitan, monooctadecanoate, poly(oxy-1,2-ethanediyl) derivs.
FRI - indicates a polymeric substance containing no free-radical initiator in its Inventory name but is considered to cover the designated polymer made with any free-radical initiator regardless of the amount used.
Sorbitan, monooctadecanoate, poly(oxy-1,2-ethanediyl) derivs.: Does not have an individual approval but may be used under an appropriate group standard
Hazards Summary
No evidence of reproductive or developmental toxicity in rats; [ToxPlanet: Shepard's Catalog of Teratogenic Agents] Causes pigmented or nucleated red blood cells and changes in erythrocyte count in 95-week constant oral studies of mice; Oral LD50 (rat) > 60 mL/kg; [RTECS] Acceptable daily intake (ADI) of 0-25 mg/kg; [JECFA] Not considered hazardous by GHS classification; [Sigma-Aldrich MSDS]
EPA Safer ChemicalChemical: Sorbitan, monooctadecanoate, poly(oxy-1,2-ethanediyl) derivs.
Toxikologische Informationen
Toxicity Summary
The CIR Expert Panel concluded that the polysorbates listed below are safe in cosmetics when formulated to be nonirritating. This conclusion supersedes the conclusion reached in the 1984, 2000, and 2001 CIR safety assessments...Polysorbate 60...
Safe for use in cosmetics, with qualifications
Sicherheitsdaten
- wgk
- 1
- tsca
- TSCA listed
- hs_code
- 34021300
- RTECS-Nr.
- WG2934000
- Toxizität
Chemie und Industrie
Pharmakologische Informationen
Cellular LocationsMembrane
Verwendung und Herstellung
Uses
CIR ingredient: Polysorbate 60
Used as a flavoring agent, emulsifier, boiler water additive, surface-active agent, and stabilizer or thickener for foods; [FDA] Used in cosmetics, pharmaceuticals, as a lubricant and finish emulsifier for textile and leather manufacture, laboratory reagent, and flavoring; [ECHA REACH Registrations] Permitted for use as an inert ingredient in non-food pesticide products; [EPA]
Leather Tanning and Processing [Category: Industry]
Use Classification
EPA Safer Chemical Functional Use Classes -> Surfactants
Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern
Fragrance Ingredients
Food Additives -> EMULSIFIER -> JECFA Functional Classes
Food Additives -> EMULSIFIER -> JECFA Functional Classes
General Manufacturing InformationSorbitan, monooctadecanoate, poly(oxy-1,2-ethanediyl) derivs.: ACTIVE
Anwendungen
VerwendenTween 60 is an emulsifier manufactured by reacting stearic acid with sorbitol to yield a product which is reacted with ethylene oxide. It is a nonionic, waterdispersible surface-active agent which is very hydrophilic. It is also termed polysorbate 60. It is used in whipped vegetable toppings for overrun and lightness; in cakes for increased volume and fine grain; in icings and confectionery for lightness and syneresis control; and in salad dressing for emulsion stability. It is frequently used with sorbitan monostearate or monoand diglycerides. The typical usage range is 0.10–0.40%.
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