C.I. Pigment Green 21

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.

Warning: Ingestion generally produces symptoms within 30 minutes but may be delayed for several hours. Caution is advised.

General First Aid:

· Wear positive pressure self-contained breathing apparatus (SCBA).

Biological Exposure Indices (BEI) [ACGIH] - Inorganic arsenic plus methylated metabolites in urine = 35 ug As/L; end of workweek;

0.01 [mg/m3], respirable fraction (Cu inorg. Compds.)[German Research Foundation (DFG)]

Extinguish fire, using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide.

Personnel protection: ... Wear positive pressure self-contained breathing apparatus when fighting fires involving this material.

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, liquid, NOS/

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, solid, NOS/

Personnel protection: ... Wear positive pressure self-contained breathing apparatus when fighting fires involving this material. /Arsenical cmpd, solid, NOS/

IN GENERAL, MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMP INTO TOXIC COMPONENTS ... SHOULD BE STORED IN A COOL, WELL-VENTILATED PLACE, OUT OF DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, & SHOULD BE PERIODICALLY INSPECTED ... INCOMPATIBLE MATERIALS SHOULD BE ISOLATED FROM EACH OTHER.

Protect container against physical damage. Store in well ventilated area away from food or food products and combustible materials. /Inorganic arsenic cmpd/

Environmental considerations: Land spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.

Environmental considerations: Water spill: Neutralize with agricultural lime (slaked lime), crushed limestone, or sodium bicarbonate. Remove trapped material with suction hoses. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.

Prompt cleanup and removal are necessary. Control runoff and isolate discharged material for proper disposal.

Floors and other accessible surfaces contaminated with inorganic arsenic may not be cleaned by the use of compressed air, and shoveling and brushing may be used only where vacuuming or other relevant methods have been tried and found not to be effective. /Inorganic arsenic compounds/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D004, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.

Chemical Treatability of Arsenic; Concentration Process: Chemical Precipitation; Chemical Classification: Metal; Scale of Study: Pilot Scale; Type of Wastewater Used: Domestic Wastewater + Pure Compound; Results of Study: 5ppm @ 4gpm @ pH= 7.0. Iron system-90% reduction; low lime system-80% reduction; high lime system-76% reduction; (3 coagulant systems were used; Iron system used 45 ppm as Fe of Fe2(SO4)3 @ pH= 6.0. Low lime system used 20 ppm Fe of Fe2(SO4)3 and 260 ppm of CaO @ pH= 10.0. High lime system used 600 ppm of CaO @ pH= 11.5. Chemical coagulation was followed by multimedia filtration). /Arsenic cmpd/

Chemical Treatability of Arsenic; Concentration Process: Chemical Precipitation; Chemical Classification: Metal; Scale of Study: Full Scale Continuous Flow; Type of Wastewater Used: Domestic Wastewater; Results of Study: Effluent character (ppb): 2.5, 56% reduction with lime; 3.3, 24% reduction with lime; (lime dose of 350-400 ppm as calcium oxide @ pH= 11.3). /Arsenic cmpd/

If material not involved in fire: Keep material out of water sources and sewers.

Personnel protection: Avoid breathing dusts, and fumes from burning material. Keep upwind. Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. ... If contact with the material anticipated, wear appropriate chemical protective clothing.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

For more Preventive Measures (Complete) data for PARIS GREEN (21 total), please visit the HSDB record page.

Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:

Immediate precautionary measure

Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20)

People must absorb small amounts of copper every day because copper is essential for good health, however, high levels of copper can be harmful. Very-high doses of copper can cause damage to your liver and kidneys, and can even cause death. Copper may induce allergic responses in sensitive individuals. Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20, L278, L279)

LC50 COLINIS VIRGINIANUS (BOBWHITE QUAIL) IN 5 DAY DIET 480 PPM (95% CONFIDENCE LIMIT 206-2042 PPM), AGE 14 DAYS /PURITY 97.4%.

LC50 COTURNIX COTURNIX JAPONICA (JAPANESE QUAIL) IN 5 DAY DIET 1204 PPM (95% CONFIDENCE LIMIT 1069-1351 PPM), AGE 20 DAYS /PURITY 97.4%/.

LC50 PHASIANUS COLCHICUS (RING-NECK PHEASANT) IN 5 DAY DIET 1043 (95% CONFIDENCE LIMIT 896-1217 PPM), AGE 10 DAYS /PURITY 97.4%/.

LC50 ANAS PLATYRHYNCHOS (MALLARD DUCK) IN 5 DAY DIET GREATER THAN 5000 PPM (NO MORTALITY TO 1900 PPM, 10% @ 2625 PPM, 20% @ 5000 PPM) /PURITY 97.4%/

For more Ecotoxicity Values (Complete) data for PARIS GREEN (9 total), please visit the HSDB record page.

Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes become saturated and copper accumulates in the nucleus, causing nuclear damage. This damage is possibly a result of oxidative damage, including lipid peroxidation. Copper inhibits the sulfhydryl group enzymes such as glucose-6-phosphate 1-dehydrogenase, glutathione reductase, and paraoxonases, which protect the cell from free oxygen radicals. It also influences gene expression and is a co-factor for oxidative enzymes such as cytochrome C oxidase and lysyl oxidase. In addition, the oxidative stress induced by copper is thought to activate acid sphingomyelinase, which lead to the production of ceramide, an apoptotic signal, as well as cause hemolytic anemia. Copper-induced emesis results from stimulation of the vagus nerve. Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17, L277, T49, A174, L280)

Breathing high levels of copper can cause irritation of the nose and throat. Ingesting high levels of copper can cause nausea, vomiting, diarrhea, headache, dizziness, and respiratory difficulty. Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of

A highly characteristic dermatitis confined to the scrotum, inguinal area, and nasolabial folds may follow moderate occupational exposure to paris green. The lesions begin with erythema, frequently become eczematous and weeping, & may start to heal with ... black scab. A sensitization reaction may be involved ... In less acute cases, hyperkeratosis, hyperhidrosis, or melanosis may occur. ... The hyperpigmentation is most marked on surfaces exposed to light. ... There may be a speckled depigmentation of pigmented areas giving the so called raindrop appearance.

Sixty four workers in a malaria control unit sprayed Baytex, Temephos (both organic thiophosphates), and paris green in oil for 5-6 hr per day without use of protective clothing, face masks, or gloves. Fourteen members of the group, aged 24-42 yr with exposure in the range 1-8 yr, had macular involvement. Symptoms incl visual impairment, dislike of bright light, night blindness, black dots in front of the eyes, and blurring of vision. Visual acuity was reduced in 9 subjects. Macular degeneration was characterized by areas of perifoveal depigmentation, dull foveal reflex, and bilaterial lesions.

TOXICITY PRIMARILY RESULT OF ARSENIC CONTENT.

It is toxic by inhalation (dust) & by ingestion.

For more Human Toxicity Excerpts (Complete) data for PARIS GREEN (7 total), please visit the HSDB record page.

Copper acetoarsenite was evaluated for mutagenicity in the Salmonella/microsome preincubation assay using a standard protocol approved by the National Toxicology Program. Copper acetoarsenite was tested at doses of 0, 3, 10, 33, 100, and 333 ug/plate in four Salmonella typhimurium strains (TA98, TA100, TA1535, and TA1537) in the presence and absence of Aroclor induced rat or hamster liver S9. Copper acetoarsenite was negative in these tests and the highest ineffective dose level tested in any Salmonella tester strain was 333 ug/plate.

Classification of carcinogenicity: 1) evidence in humans: sufficient; 2) evidence in animals: limited. Overall summary evaluation of carcinogenic risk to humans is Group 1: Carcinogenic to humans. NOTE: This evaluation applies to the group of chemicals as a whole and not necessarily to all individual chemicals within the group. /Arsenic and arsenic compounds/

CLASSIFICATION: A; human carcinogen. BASIS FOR CLASSIFICATION: Based on sufficient evidence from human data. An increased lung cancer mortality was observed in multiple human populations exposed primarily through inhalation. Also, increased mortality from multiple internal organ cancers (liver, kidney, lung, and bladder) and an increased incidence of skin cancer were observed in populations consuming drinking water high in inorganic arsenic. HUMAN CARCINOGENICITY DATA: Sufficient. ANIMAL CARCINOGENICITY DATA: Inadequate. /Inorganic Arsenic/

A1: Confirmed human carcinogen. /Arsenic and inorganic cmpd, as As/

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, liquid, NOS/

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, solid, NOS/

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Paris green is included on this list.

(a) The owner or operator of an existing glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (a)(1) or (a)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 2.5 Mg (2.7 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/

(b) The owner or operator of a new or modified glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (b)(1) or (b)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 0.4 Mg (0.44 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/

The owner or operator of each copper converter subject to the provisions of this subpart shall reduce inorganic arsenic emissions to the atmosphere by meeting the following design, equipment, work practice, and operational requirements: (1) Install, operate, and maintain a secondary hood system on each copper converter. Each secondary hood system shall consist of a hood enclosure, air curtain fan(s), exhaust system fan(s), and ductwork that conveys the captured emission to a control device ... (2) Optimize the capture of secondary inorganic arsenic emission by operating the copper converter and secondary hood systems at all times ... . /Inorganic arsenic/

For more Atmospheric Standards (Complete) data for PARIS GREEN (6 total), please visit the HSDB record page.

Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Cupric acetoarsenite is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 500 or 10,000 lbs. Extremely hazardous substances that are solids are subject to either of two threshold planning quantities ... The lower quantity applies only if the solid exists in powdered for and has a particle size less than 100 microns; or is handled in solution or in molten form; or meets the criteria for a National Fire Protection Association (NFPA) rating of 2, 3 or 4 for reactivity. If the solid does not meet any of these criteria, it is subject to the upper ... threshold planning quantity ... .

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1 lb or 0.454 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

Cupric acetoarsenite is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance.

Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Copper and cmpd/

Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Arsenic & cmpd/

The national primary drinking water maximum contaminant level (MCL) for inorganic arsenic is 0.05 mg/l. /Inorganic arsenic/

For the maximum protection of human health from the potential carcinogenic effects due to exposure of arsenic through ingestion of contaminated water & contaminated aquatic organisms, the ambient water concn should be zero based on the nonthreshold assumption for this chemical. However, zero level may not be attainable at the present time. Therefore, the levels which may result in incremental increase of cancer risk over the lifetime are estimated at 1X10-5, 1X10-6, & 1X10-7. The corresponding criteria are 22 ng/l, 2.2 ng/l, & .22 ng/l, respectively .... For consumption of aquatic organisms only, excluding consumption of water, the levels are 175 ng/ml, 17.5 ng/l, & 1.75 ng/l, respectively. /Arsenic/

D004; A solid waste containing arsenic may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste.

(AZ) ARIZONA 10 ug/L /Arsenic/

(CT) CONNECTICUT 10 ug/l /Arsenic/