| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 2.3% (25 of 1096) of reports.DangerH272 (94.2%): May intensify fireoxidizer [Danger Oxidizing liquidsOxidizing solids]P210, P220, P261, P264+P265, P271, P280, P304+P340, P305+P351+P338, P319, P337+P317, P370+P378, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 1096 reports by companies from 30 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Not Classified |
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| Regulatorische Informationen | Chemical: Nitric acid, ammonium saltNitric acid ammonium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Nitric acid ammonium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 31-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15999Restricted substance: Ammonium nitrate (AN)Nitric acid, ammonium salt: HSNO Approval: HSR001310 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
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| Weitere Sicherheitsinformationen | IMAP assessments - Nitric acid, ammonium salt: Human health tier II assessment |
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| DOT-Kennzeichnung | OxidizerOxidizer Class 9Explosive 1.1D |
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| Brandgefahren | Excerpt from ERG Guide 140 [Oxidizers]:Excerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:CAUTION: Ammonium nitrate products may explode if involved in fire or contaminated with hydrocarbons (fuels), organic matter, other contaminants or when hot molten and contained. Treat as an explosive (GUIDE 112). |
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| Gesundheitsgefahren | Excerpt from ERG Guide 140 [Oxidizers]:Excerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:· Inhalation, ingestion or contact (skin, eyes) with vapors or substance may cause severe injury, burns or death. |
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| Gefahrenübersicht | Listed in table of Methemoglobinemia-inducing agents: industrial, environmental, and pharmaceutical[Sullivan, p. 729] Ruminants may develop methemoglobinemia from the ingestion of nitrate compounds (Nitrates are converted into nitrites in the rumen.) [HSDB] A skin, eye, and respiratory tract irritantCan induce methemoglobinemia[ICSC] See NITRATES and NITRITES. |
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| DOT-Nummer und Handbuch | 2426 1401942 140 |
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| Reaktive Gruppe | Salts, Acidic |
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| UN-Einstufung | UN Hazard Class: 5.1UN Pack Group: III |
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| Special Reports | The Environmental Protection Agency (EPA), the Occupational Safety and Health Administration (OSHA), and the Bureau of Alcohol, Tobacco, Firearms, and Explosives (ATF) ("we") are issuing this advisory as part of an ongoing federal effort to improve chemical risk management, and to advance safety and protect human health and the environment. This advisory contains information on recent and past accidents involving AMMONIUM NITRATE (commonly referred to as AN), on the hazards of AN, how to manage these hazards, and appropriate steps for community emergency planning and proper emergency response. It is focused primarily on safe handling and storage of higher density, solid AN pellets and prills (a prill is a small bead) used in fertilizers. This advisory is intended to broadly disseminate lessons learned from recent incidents involving AN so that such incidents can be prevented in the future. Also provided is a list of information resources, including relevant codes and standards, industry publications, and applicable statutes and regulations that will help facilities handling AN and first responders better understand the hazards so they can effectively manage the risks. The information provided is not intended to cover all the hazards, safe practices or technical challenges associated with the manufacturing of ANliquid fertilizers containing ANmanufacturing, storage or use of explosives or blasting agents containing ANor the transportation of AN. For these particular situations, please consult other sources including the appropriate references, standards and regulations, cited at the end of this document.[EPA/OSHA/ATFChemical Advisory: Safe Storage, Handling, and Management of Ammonium Nitrate EPA 550-S-13-001, p.6 (August 2013). Available from, as of November 21, 2013: http://www.epa.gov/oem/docs/chem/AN_advisory.pdf]Environment CanadaTech Info for Problem Spills: Ammonium Nitrate (Draft) (1981) |
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| EPA Safer Chemical | Chemical: Ammonium nitrate |
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| FIFRA-Anforderungen | Residues of ammonium nitrate are exempted from the requirement of a tolerance when used as a adjuvant/intensifier for herbicides in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only. |
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| Brandbekämpfung | Excerpt from ERG Guide 140 [Oxidizers]:Excerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:Use water in large amounts. NO other agents. In case of fire in the surroundings, use appropriate extinguishing media. In case of fire: keep drums, etc., cool by spraying with water. Combat fire from a sheltered position. |
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| Erste-Hilfe-Maßnahmen | Fresh air, rest. Seek medical attention if you feel unwell.Rinse skin with plenty of water or shower. Remove contaminated clothes.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Refer for medical attention . |
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| Freisetungsmaßnahmen | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· Keep combustibles (wood, paper, oil, etc.) away from spilled material. |
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| Erste Hilfe | Excerpt from ERG Guide 140 [Oxidizers]:Excerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]:General First Aid: |
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| Sichere Lagerung | Separated from combustible substances and reducing agents. Dry. Well closed. |
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| Firefighting Hazards | If subjected to strong shocks or heated under confinement causing a pressure buildup, may undergo detonation.Ammonium nitrate by itself does not burn, but in contact with other combustible materials, it increases the fire hazard. It can support and intensify a fire even in the absence of air. Fires involving ammonium nitrate can release toxic nitrogen oxides and ammonia. A fire involving ammonium nitrate in an enclosed space could lead to an explosion. Closed containers may rupture violently when heated.During a fire in a facility where ammonium nitrate is present, the ammonium nitrate can become hot and molten which makes the material very sensitive to shock and detonation, particularly if it becomes contaminated with incompatible material such as combustibles, flammable liquids, acids, chlorates, chlorides, sulfur, metals, charcoal, sawdust, etc. If a molten mass becomes confined (e.g., in drains, pipes or machinery), it can explode.Solid ammonium nitrate readily absorbs moisture, which can lead to caking, self-compression and self confinement. This in turn increases susceptibility to explosion in a fire. |
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| Expositionsschutz und Persönliche Schutzausrüstung | · Wear positive pressure self-contained breathing apparatus (SCBA). |
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| Brandbekämpfungsverfahren | Cool exposed containers with water. Continue cooling after fire has been extinguished.Use flooding quantities of water. Fight fire from protected location or maximum possible distance. Approach fire from upwind to avoid hazardous vapors & toxic decomposition products. Fire situations may require evacuation.If material on fire or involved in fire: Dangerously explosive. Do not fight fires in a cargo of explosives. Evacuate area and let burn. /explosives/If material on fire or involved in fire: Flood with water. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. /oxidizer and liquid (oxidizer)/For more Fire Fighting Procedures (Complete) data for AMMONIUM NITRATE (7 total), please visit the HSDB record page. |
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| Lagerbedingungen | Closed containers may rupture violently when heated.KEEP WELL CLOSED.Separate from acids, alkalies, reducing agents, combustible materials. Store in a cool, dry, well ventilated location.Fire protection: Ammonium nitrate storage areas should be equipped with an automatic sprinkler system, or have an automatic fire detection and alarm system if the areas are not continuously occupied. This is especially important when the facility in question is close to the public surrounding the facility. Facilities should NOT store more than 2500 tons of bagged ammonium nitrate without an automatic sprinkler system. An automatic sprinkler system, if installed, should be provided in accordance with NFPA 13, Standard for the Installation of Sprinkler Systems. Suitable fire control devices such as hoses and appropriate portable fire extinguishers (ammonium nitrate is an oxidizer and not all fire extinguishers are appropriate) shall be provided throughout the warehouse and loading areas. Water supplies and fire hydrants should be available. Store ammonium nitrate fertilizer in separate buildings or separated by approved fire walls from organic, combustible or reactive materials, such as grains, wood or other organic materials, urea and urea compounds, flammable liquids or gases, corrosive acids, chlorates, chromates nitrites, permanganates or finely divided metals or sulfur. Ammonium nitrate fertilizer should NOT be stored in the same building with explosives or blasting agents unless conditions in ATF's Table of Separation Distances of Ammonium Nitrate and Blasting Agents from Explosives and Blasting Agents, 27 CFR 555.220, are met. Prohibit smoking in ammonium nitrate storage areas.For more Storage Conditions (Complete) data for AMMONIUM NITRATE (8 total), please visit the HSDB record page. |
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| Reinigungsverfahren | Prompt cleanup and removal are necessary in order to prevent contamination with combustible materials. |
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| Freisetung ohne Brand | Excerpt from ERG Guide 140 [Oxidizers]:Excerpt from ERG Guide 112 [Explosives - Division 1.1, 1.2, 1.3 or 1.5]: |
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| Entsorgungsverfahren | SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.Remove slowly into a large container of water. Add Na2CO3 /sodium carbonate/ slightly by stirring. After 24 hr, decant or siphon into another container. Neutralize with 6 M-HCL /6 M-hydrochloric acid/ ... . |
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| Treatment | Methemoglobinemia can be treated with supplemental oxygen and methylene blue 1% solution administered intravenously slowly over five minutes followed by IV flush with normal saline. Methylene blue restores the iron in hemoglobin to its normal (reduced) oxygen-carrying state. (L1613) |
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| Wechselwirkungen | ... The objective of our study was to examine how realistic, sublethal environmental levels of ammonium nitrate fertilizer (0, 10, 20 mg/L and ammonium chloride control) and the common insecticide carbaryl (0 or 2.5 mg/L) individually and interactively affect the development, size, and survival of green frog (Rana clamitans) tadpoles. /The authors/ reared tadpoles for 95 days in outdoor 1,000-L polyethylene ponds. /They/ found that the combination of carbaryl and nitrate had a negative effect on development and mass of tadpoles compared to the positive effect that either contaminant had alone. Presence of carbaryl was generally associated with short-term increases in algal resources, including ponds exposed to both carbaryl and nitrate. However, with exposure to nitrate and carbaryl, tadpole mass and development were not positively affected as with one chemical stressor alone... |
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| Gesundheitliche Auswirkungen | Nitrate and nitrite poisoning causes methemoglobinemia. Nitrites may cause pregnancy complications and developmental effects. They may also be carcinogenic. (L1137) |
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| Ökotoxizitätswerte | LC50Species: /Oncorhynchus mykiss (Rainbow trout)/ 6000 mg/L for 96 hr /Conditions of bioassay not specified/Species: Xenopus laevis (African clawed frog) tadpoles age 14 days, weight 17 mg, gosner stage 26-27Conditions: freshwater, static-renewal, 22 °C, pH 7.0-7.6, hardness 58.4 mg/L CaCO3, alkalinity 52.0 mg/L CaCO3, conductivity 156.0 uS/cm, dissolved oxygen 7.2 mg/LConcentration: 52.9 mg/L for 10 days (95% confidence interval: 46.6-60.0 mg/L) /99% pure/Concentration: 100.7 mg/L for 96 hr (95% confidence interval: 87.8-115.4 mg/L) /99% pure/Species: Cyprinus carpio (common carp) fry, weight 33.6 gConditions: freshwater, renewal, 13.5 °C (12.0-15.2 °C), pH 7.6 (7.2-8.2), dissolved oxygen 9.4 mg/L (9.0-9.8 mg/L)Concentration: 74 mg/L for 48 hr (95% confidence interval: 65-85 mg/L) /99% pure/For more Ecotoxicity Values (Complete) data for AMMONIUM NITRATE (13 total), please visit the HSDB record page. |
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| Umweltverhalten | Ammonium nitrate is quite soluble in water (250 g/100 mL at 20 °C). Thus, if precipitation occurs prior to clean up, or if water is used to disperse the spilled chemical, the solution of ammonium nitrate produced can infiltrate the soil and migrate downward. |
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| Unerwünschte Wirkungen | Methemoglobinemia - The presence of increased methemoglobin in the bloodthe compound is classified as secondary toxic effect |
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| Expositionspfade | The substance can be absorbed into the body by inhalation and by ingestion.Oral (L1137)inhalation (L1137) |
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| Toxizitätsübersicht | Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613) |
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| Ökotoxizitätsauszüge | /AQUATIC SPECIES/ Temporary ponds where many amphibians breed experience a gradual desiccation that leads to growing larval densities, which can reduce tadpole survival rates and increase cannibalistic interactions among carnivorous salamander larvae. Concentrations of many agrochemicals, including nitrogenous fertilizers, can also increase as the water volume decreases. /The investigators/ analyzed the effects of ammonium nitrate fertilizer at two larval densities on growth and survival of Rana dalmatina /agile frog/ tadpoles, and on cannibalistic behaviors of Salamandra salamandra /fire salamander/ larvae. /The investigators/ observed synergistic lethal effects until day 17 of exposure, when ammonium nitrate-related mortality of tadpoles was five times greater at high than at low density. The fertilizer impaired tadpole growth. This effect was stronger at low density than at high density. In the absence of ammonium nitrate, the incidence of cannibalism was higher at high than at low larval density. However, fertilizer exposure removed this density-dependent effect, which, under field conditions, would negate some potentially advantageous effects of cannibalism such as reduced intraspecific competition and the stimulation of defensive behaviors./AQUATIC SPECIES/ In static renewal experiments, ...how developmental stage influences the effect of ammonium nitrate on embryonic and larval stages of anuran amphibians /was studied/. The observed lethal effects caused by ammonium nitrate increased with both concentration and duration of exposure. Significant differences were observed in sensitivity to ammonium nitrate as a function of developmental stage in Discoglossus galganoi /Iberian painted frog/, Pelobates cultripes /western spadefoot toad/, and Bufo calamita /natterjack toad/. In D. galganoi and P. cultripes, younger individuals displayed greater acute effects from the chemical fertilizer compared with older individuals. For example, 100% of P. cultripes hatchlings died after 4 days of exposure to a nominal concentration of 225.8 mg N-NO3NH4/L, whereas <40% of individuals from older larval stages died when exposed to this concentration. A delay of 4 days in the beginning of the exposure to the chemical was enough to cause significant differences in sensitivity. Bufo calamita showed a higher sensitivity in later larval stages after 12 days of exposure. Hyla meridionalis /Mediterranean tree frog/ and B. calamita were less sensitive than the other two species. Peak ammonium nitrate concentrations usually occur when amphibians are breeding and, thus, when the most sensitive aquatic stage is in the water. The developmental stage of the test animals should be considered when evaluating the risk of ammonium nitrate to amphibians./AQUATIC SPECIES/ The min lethal toxicity of ... ammonium nitrate ... for Rana temporaria chensinensis /Chinese brown frog/ tadpoles was 0.91 g/L, and the max tolerance concn was 0.83 g/L. In field experiments, ammonium nitrate at concn of 0.25 g/L had no adverse effect on the tadpoles as reflected by their growth rate./AQUATIC SPECIES/ The effects of ammonium nitrate, ammonium chloride, ammonium sulfate, and sodium nitrate on survival and growth of Pacific treefrog (Pseudacris regilla [Baird and Girard]) and African clawed frog (Xenopus laevis [Daudin]) tadpoles were determined in static-renewal tests. The 10-day ammonium nitrate and ammonium sulfate LC50s for P. regilla were 55.2 and 89.7 mg/L NH4-N, respectively. The 10-day LC50s for X. laevis for the three ammonium compounds ranged from 45 to 64 mg/L NH4-N. The 10-day sodium nitrate LC50s were 266.2 mg/L NO3-N for P. regilla and 1,236.2 mg/L NO3-N for X. laevis. The lowest observed adverse effect level (LOAEL) of ammonium compound based on reduced length or weight was 24.6 mg/L NH4-N for P. regilla and 99.5 mg/L NH4-N for X. laevis. The lowest sodium nitrate LOAELs based on reduced length or weight were <30.1 mg/L NO3-N for P. regilla and 126.3 mg/L NO3-N for X. laevis. Calculated un-ionized NH3 comprised 0.3 to 1.0% of measured NH4-N concentrations. Potential harm to amphibians could occur if sensitive life stages were impacted by NH4-N and NO3-N in agricultural runoff or drainage for a sufficiently long period.For more Ecotoxicity Excerpts (Complete) data for AMMONIUM NITRATE (11 total), please visit the HSDB record page. |
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| Signs and Symptoms | Cough.Redness.Redness. Pain.Vomiting. Diarrhoea. Blue lips, fingernails and skin. Weakness.Nitrate and nitrite poisoning causes methemoglobinemia. Symptoms include cyanosis, cardiac dysrhythmias and circulatory failure, and progressive central nervous system (CNS) effects. CNS effects can range from mild dizziness and lethargy to coma and convulsions. (L1137) |
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| Ongoing Test Status | The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from, as of November 11, 2013: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=6484-52-2] |
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| ICSC Environmental Data | Avoid release to the environment in circumstances different to normal use. |
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| DHS Chemicals of Interest (COI) | Ammonium nitrate, [with more than 0.2 percent combustible substances, including any organic substance calculated as carbon, to the exclusion of any other added substance]A Commercial Grade5,000400Explosive chemical that can be released at a facility. |
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