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Bemegrid

Bemegride

HCID 2310
NotizenReaktionen
GrundinformationenÜberblickNamen und BezeichnerEigenschaftenSicherheit und RegulatorischesChemie und IndustrieZugehörige ReaktionenNotizen zur Verbindung
TeilstruktursucheÄhnliche Strukturen suchen

Grundinformationen

CAS
64-65-3
Standard-SMILES
CCC1(C)CC(=O)NC(=O)C1
InChIKey
ORRZGUBHBVWWOP-UHFFFAOYSA-N
Summenformel
C8H13NO2
Durchschnittliche Molmasse
155,19 g/mol
Monoisotopische Masse
155,09462866

Überblick

Bemegride is a white crystalline solid. Sublimes at 212 °F and 200 mm pressure. (NTP, 1992)

Namen und Bezeichner

Bevorzugter Name
Bemegride
IUPAC
4-ethyl-4-methylpiperidine-2,6-dione
Lokaler Name
Bemegrid
Englischer Name
3-Ethyl-3-methylglutarimide
Summenformel
C8H13NO2
Molmasse
155.19

Namen und Synonyme

bemegride64-65-33-Ethyl-3-methylglutarimide4-ethyl-4-methylpiperidine-2,6-dioneMethetharimideMegibalMegimideMikedimideEukratonZentraleptinBemegridAhypnon
Weitere Namen anzeigen
NP-13DPX6573
MalysolMegimidAntibarbiAgipnonBemegrida3-Methyl-3-ethylglutarimideBemegridumbeta-Ethyl-beta-methylglutarimide

Datenbank-Bezeichner

CAS
64-65-3
PubChem CID
2310
DTXSID
DTXSID0045250
ChEMBL
CHEMBL1214192
ChEBI
CHEBI:92269
UNII
57DQA39DO2
EC Number
200-588-0
Nikkaji
J1.404D

Eigenschaften

Berechnete Struktureigenschaften

XLogP
0,7
Polarare Oberfläche (TPSA)
46,2 Ų
H-Brücken-Donoren
1
H-Brücken-Akzeptoren
2
Frei drehbare Bindungen
1
Schwere Atome
11
Formalladung
0
Komplexität
182

Experimentelle und physikochemische Eigenschaften

DrugsDEA NFLIS-Drug Category -> Stimulants
Solubilityless than 1 mg/mL at 68 °F (NTP, 1992)
Melting Point259 to 261 °F (NTP, 1992)
Physical DescriptionBemegride is a white crystalline solid. Sublimes at 212 °F and 200 mm pressure. (NTP, 1992)

Physikochemische Eigenschaften

Schmelzpunkt
126 · 126-127 °C(lit.)
Siedepunkt
279 °C · 279°C (rough estimate)
Dichte
1.1174 · 1.1174 (rough estimate)
Brechungsindex
1.486 · 1.4860 (estimate)
storage temp.
2 · Sealed in dry,2-8°C
Wasserlöslichkeit
Soluble in water
Löslichkeit
31 · DMSO:31.0(Max Conc. mg/mL);199.76(Max Conc. mM)Ethanol:31.0(Max Conc. mg/mL);199.76(Max Conc. mM)

Sicherheit und Regulatorisches

Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.

GHS-Klassifizierung

GHS Classification · 4 Einträge

Danger

H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]

P261, P262, P264, P270, P271, P280, P301+P316, P302+P352, P304+P340, P316, P321, P330, P361+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 40 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Gefahrenhinweise

DOT LabelPoison
Fire HazardsFlash point data for this chemical are not available. It is probably not flammable. (NTP, 1992)
Health HazardsACUTE/CHRONIC HAZARDS: When heated to decomposition it emits toxic fumes. (NTP, 1992)
Reactive GroupAmides and Imides
Reactivity Profile · 1 Eintrag

BEMEGRIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Air and Water ReactionsInsoluble in water.
Hazard Classes and CategoriesAcute Tox. 2 (100%)

Chemie und Industrie

Pharmakologische Informationen

ATC Code · 2 Einträge

R - Respiratory system

QR - Respiratory system

MeSH Pharmacological Classification · 3 Einträge

A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.

Substances that act in the brain stem or spinal cord to produce tonic or clonic convulsions, often by removing normal inhibitory tone. They were formerly used to stimulate respiration or as antidotes to barbiturate overdose. They are now most commonly used as experimental tools.

Drugs used for their effects on the respiratory system.

Verwendung und Herstellung

General Manufacturing Information2,6-Piperidinedione, 4-ethyl-4-methyl-: INACTIVE

Anwendungen

VerwendenCNS stimulant;GABA antagonist

Anbieter77 Anbieter

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Zugehörige Reaktionen

0
Reaktionsaufzeichnung erstellen

Keine Reaktionsaufzeichnungen unter den aktuellen Filterkriterien.

Notizen zur Verbindung

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Auf dieser SeiteGrundinformationenÜberblickNamen und BezeichnerEigenschaftenSicherheit und RegulatorischesChemie und IndustrieZugehörige ReaktionenNotizen zur Verbindung
Aggregatzustand
powder
pka
11.7 · pKa 11.7 (Uncertain)
Farbe
white
Merck
14 · 14,1027
InChI
InChI=1S/C8H13NO2/c1-3-8(2)4-6(10)9-7(11)5-8/h3-5H2,1-2H3,(H,9,10,11)
InChIKey
ORRZGUBHBVWWOP-UHFFFAOYSA-N
SMILES
N1C(=O)CC(CC)(C)CC1=O
CAS Datenbank
64 · 64-65-3(CAS DataBase Reference)
EPA chemische Informationen
Bemegride (64-65-3)

Sicherheit und Schutzausrüstung

Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 Eintrag

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 Eintrag

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Isolation and EvacuationExcerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:
Personal Protective Equipment (PPE) · 1 Eintrag

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

Sicherheitsdaten

wgk
3
tsca
TSCA listed
ridadr
UN 2811 6.1/PG 2
hs_code
2933399990
RTECS-Nr.
MA4550000
risk_code
23/24/25
Toxizität
LD50 in male mice (mg/kg): 20.1 ±1.41 i.v., 43.0 ±1.8 s.c.; LD50 in male rats (mg/kg): 16.3 ±1.24 i.v., 23.5 ±1.67 i.p (Hahn, Oberdorf)
hazard_code
T
safety_code
22-36/37/39-45
hazard_class
6.1(a)
packing_group
II
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