SR 0987
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Grundinformationen
- CAS
303126-97-8- Standard-SMILES
O=C(Nc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1)c1ccccc1Cl- InChIKey
IZVBONMVWLTLNT-UHFFFAOYSA-N- Summenformel
- C16H10ClF6NO2
- Durchschnittliche Molmasse
- 397,7 g/mol
Namen und Bezeichner
- Bevorzugter Name
- SR 0987
- Englischer Name
- SR 0987
- Summenformel
- C16H10ClF6NO2
- Molmasse
- 397.7
Namen und Synonyme
SR 0987SR0987 >=98% (HPLC)SR0987, 10 mM in DMSOSR 0987SR-0987SR0987303126-97-8SR0987,ROR,SR-0987,Inhibitor,SR 0987,inhibit,RAR-related orphan receptor2-chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)benzamide2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamideBenzamide, 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-
Datenbank-Bezeichner
- CAS
303126-97-8- PubChem CID
- 2323435
- ChEMBL
CHEMBL5265778- EC Number
- 110-754-3
- Nikkaji
- J3.781.073H
Eigenschaften
Physikochemische Eigenschaften
- Siedepunkt
- 378.8 · 378.8±42.0 °C(Predicted)
- Dichte
- 1.525 · 1.525±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · Sealed in dry,Store in freezer, under -20°C
- Löslichkeit
- Soluble in DMSO (up to at least 25 mg/ml) and Ethanol (up to at least 25 mg/ml)
- pka
- 9.22 · 9.22±0.15(Predicted)
- Aggregatzustand
- solid
- Farbe
- White
- Stabilität
- 1 year · Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- InChIKey
- IZVBONMVWLTLNT-UHFFFAOYSA-N
- SMILES
- FC(F)(F)C(O)(C(F)(F)F)c1ccc(cc1)NC(=O)c2c(cccc2)Cl
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- WGK 3
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Acute Tox. 4 OralAquatic Acute 1Aquatic Chronic 1
Chemie und Industrie
Anwendungen
BeschreibungSR 0987 is an agonist of the T cell-specific isoform of RORγ (RORγt, retinoic acid receptor-related orphan receptor-γt), inducing reporter gene expression with an EC50 value of ~800 nM. Stimulation of mouse EL4 T lymphocytes with SR 0987, following activation with PMA and ionomycin , increases expression of the RORγt target IL-17, while expression of the programmed cell death protein PD-1 is decreased and granzyme B is unchanged. Decreased cell surface PD-1 protein, assessed by flow cytometry, is observed in a variety of T cells treated with SR 0987.
VerwendenSR 0987 is a RORγt agonist.
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