Benzquinamide

130-131.5

130-131.5 °C

131 °C

2H-Benzoaquinolizine-3-carboxamide, 2-(acetyloxy)-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

DROWSINESS APPEARS TO BE MOST COMMON ADVERSE EFFECT. OTHER ADVERSE REACTIONS... /INCL/ DRY MOUTH, SHIVERING, SWEATING, HICCOUGHS, FLUSHING, SALIVATION, & BLURRED VISION...HYPERTENSION, HYPOTENSION, DIZZINESS, ATRIAL FIBRILLATION, & PREMATURE AURICULAR & VENTRICULAR CONTRACTIONS...INSOMNIA, RESTLESSNESS, HEADACHE... /HCL/

...ADVERSE REACTIONS REPORTED ARE AS FOLLOWS: ...EXCITEMENT, NERVOUSNESS... ANOREXIA, NAUSEA...TWITCHING, SHAKING, TREMORS, & WEAKNESS...FATIGUE, CHILLS, INCR TEMP. /HCL/

The mechanism of action is not known, but presumably benzquinamide works via antagonism of muscarinic acetycholine receptors and histamine H1 receptors.

LIKE PHENOTHIAZINES, IT APPARENTLY INHIBITS STIMULI @ CHEMORECEPTOR TRIGGER ZONE. HOWEVER, IN CONTRAST...INCR CARDIAC OUTPUT, BLOOD PRESSURE, & RESP HAVE BEEN NOTED BOTH EXPTL & CLINICALLY WITH BENZQUINAMIDE. /HCL/

BENZQUINAMIDE YIELDS 2-ACETOXY-3-(N,N-DIETHYLCARBOXAMI DO)-1,2,3,4,6,7-HEXAHYDRO-9-HYDROXY-10-METHOXY-11BH-BENZOQUINOLIZINE & 2-ACETOXY-3-(N-ETHYLCARBOXAMIDO)-1,2,3,4,6,7-HEXAHYDRO- 9,10-DIMETHOXY-11BH-BENZOQUINOLIZINE IN MAN & DOG: WISEMAN, EH ET AL, BIOCHEM PHARMAC 13, 1421 (1964). /FROM TABLE/

BENZQUINAMIDE YIELDS 3-(N,N-DIETHYLCARBOXAMIDO)-1,2,3, 4,6,7-HEXAHYDRO-2-HYDROXY-9,10-DIMETHOXY-11BH-BENZOQUINOLIZINE IN MAN & DOG: WISEMAN, EH ET AL, BIOCHEM PHARMAC 13, 1421 (1964). /FROM TABLE/