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Benzylbutylphthalat
BBP · BUTYL BENZYL PHTHALATE · Benzyl butyl ester · PHTHALIC ACID, BENZYLBUTYL ESTER · CW17 · mZFM · SF01 · Sicol
Identifikatoren & physikalische Daten
| CAS No. | 85-68-7 |
|---|---|
| Summenformel | C19H20O4 |
| Durchschnittliche Molmasse | 312,4 g/mol |
| Monoisotopische Masse | 312,13615912 g/mol |
| SMILES | CCCCOC(=O)c1ccccc1C(=O)OCc1ccccc1 |
| InChIKey | IRIAEXORFWYRCZ-UHFFFAOYSA-N |
| PubChem CID | 2347 |
| ChEMBL | CHEMBL1450327 |
| ChEBI | CHEBI:34595 |
| EC No. | 201-622-7 |
| DTXSID | DTXSID3020205 |
| Lokaler Name | Benzylbutylphthalat |
Chemische & physikalische Eigenschaften
| XLogP | 4,9 |
|---|---|
| Polarare Oberfläche (TPSA) | 52,6 |
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 9 |
| Schwere Atome | 23 |
| Formalladung | 0 |
| Komplexität | 374 |
| Stoffklassen | CarcinogensPhthalateSemi-Volatile Organic Compound (SVOC) |
| Polymers | Plastics & Rubber -> Phthalate Esters |
| Kosmetika | Cosmetic ingredients (Butyl Benzyl Phthalate) -> CIR (Cosmetic Ingredient Review) |
| SpringerMaterials Properties | Boiling point |
| Pestizide | Pesticide -> EPA IRIS |
| LogP (Verteilungskoeffizient) | log Kow = 4.734.774.5 |
| Geruch | Slight odor |
| Geschmack | Bitter |
| Dichte | 1.12 at 68 °F (USCG, 1999) - Denser than waterwill sink1.119 g/cu cm at 25 °CRelative density (water = 1): 1.11.116 @25 °C1.1 g/mL at 25 °C(lit.) |
| Color/Form | Clear, oil liquid |
| Löslichkeit | less than 0.1 mg/mL at 72.5 °F (NTP, 1992)In water, 2.69 mg/L at 25 °CSolubility in water, mg/l: 0.71 (very poor)DMSO: 100 mg/mL (320.14 mM)0.000269 g/100 mL |
| Flammpunkt | 390 °F (NTP, 1992)390 °F (199 °C) (Closed Cup)198 °C>230 °F |
| Schmelzpunkt | <-35°C |
| Siedepunkt | 370°C |
| Dampfdichte | 10.8 (vs air) |
| Pour Point | -45 |
| Dampfdruck | 0.16 mm Hg ( 150 °C) |
| Brechungsindex | n20/D 1.54(lit.) |
| Lagerbedingungen | room temp |
| Aggregatzustand | Oily Liquid |
| Wichte | 1.1 |
| Farbe | Clear |
| Biologische Quelle | rabbit |
| BRN | 2062204 |
| Henry-Konstante | (x 10-6 atmm3/mol): 1.3 at 25 °C (calculated, Howard, 1989) |
| Hauptanwendungen | cleaning productscosmeticsenvironmentalfood and beveragespersonal care |
| Kosmetik-Inhaltsstoffe Funktionen | PLASTICISER |
| InChI | 1S/C19H20O4/c1-2-3-13-22-18(20)16-11-7-8-12-17(16)19(21)23-14-15-9-5-4-6-10-15/h4-12H,2-3,13-14H2,1H3 |
| InChIKey | IRIAEXORFWYRCZ-UHFFFAOYSA-N |
| SMILES | CCCCOC(=O)c1ccccc1C(=O)OCc2ccccc2 |
| LogP (Verteilungskoeffizient) | 4.84 at 20℃ |
| CAS Datenbank | 85-68-7(CAS DataBase Reference) |
| NIST chemische Informationen | Phthalic acid, benzyl butyl ester(85-68-7) |
| EPA chemische Informationen | Butyl benzyl phthalate (85-68-7) |
Sicherheit & Vorschriften
| GHS-Einstufung | DangerH360Df: May damage the unborn childSuspected of damaging fertility [Danger Reproductive toxicity]P203, P273, P280, P318, P391, P405, and P501 (click each P-code to see the statement)H360 (> 99.9%): May damage fertility or the unborn child [Danger Reproductive toxicity] |
|---|---|
| Regulatorische Informationen | Chemical: 1,2-Benzenedicarboxylic acid, 1-butyl 2-(phenylmethyl) esterHazard Traits - Developmental ToxicityEndocrine ToxicityHepatotoxicity and Digestive System ToxicityImmunotoxicityNeurotoxicityReproductive ToxicityRespiratory ToxicityRegulation (EC) No 178/2002 (amended)1,2-Benzenedicarboxylic acid, 1-butyl 2-(phenylmethyl) ester is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2-Benzenedicarboxylic acid, 1-butyl 2-(phenylmethyl) ester are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)REACH registered substance: Benzyl butyl phthalate (EC: 201-622-7)Restricted substance: Benzyl butyl phthalate (BBP) |
| Weitere Sicherheitsinformationen | IMAP assessments - C4-6 side chain transitional phthalates: Human health tier II assessment |
| DOT-Kennzeichnung | Class 9 |
| Brandgefahren | Special Hazards of Combustion Products: Irritating vapors of unburned chemical may form in fires. (USCG, 1999)Combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
| Brandpotenzial | Combustible |
| Gesundheitsgefahren | Prolonged contact with liquid causes some irritation of eyes and skin. (USCG, 1999) |
| Gefahrenübersicht | Animal tests show that this substance possibly causes toxicity to human reproduction or development. [ICSC] Like dioctyl phthalate, it may cause CNS depression and mild liver toxicity after ingestion of large amounts[HSDB] Causes damage to testes and genital tract in high-dose animal studiesNo human data[REPROTOX] Low oral toxicityOral LD50 (rat) >2000 mg/kgHas effects on the CNS, kidneys, and liver at high dosesSome evidence of carcinogenicity in male ratsFurther studies on reproductive effects in animals are needed[Reference #1] An irritant[MSDSonline] See PHTHALATE ESTERS. |
| FDA-Anforderungen | Butyl benzyl phthalate is an indirect food additive for use only as a component of adhesives. |
| Reaktive Gruppe | Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters |
| EG-Einstufung | Symbol: T, NR: 61-62-50/53S: 45-53-60-61 |
| UN-Einstufung | UN Hazard Class: 9UN Pack Group: III |
| Special Reports | DHHS/NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Butyl Benzyl Phthalate (BBP) (2003) NIH Publication No. 03-4487. BBP is one of 7 phthalate chemicals evaluated by the NTP CERHR Phthalates Expert Panel. These phthalates were selected for evaluation because of high production volume, extent of human exposures, use in children's products, and/or published evidence of reproductive or developmental toxicity. NTP-CERHR monographs are transmitted to federal and state agencies, interested parties, and the public and are available in electronic PDF format on the CERHR web site and in printed text or CD-ROM from the CERHR.[Available from, as of May 20, 2008: http://cerhr.niehs.nih.gov]European Chemicals BureauIUCLID Robust Summaries & Test Plans: Phthalate Esters Category, Benzyl butyl phthalate (85-68-7) (2000 CD-ROM edition) contains information on use, toxicology, and environmental effects of this chemical as supplied to the European Union by industry.[Available from, as of May 20, 2008: http://esis.jrc.ec.europa.eu/]Pierce RC et alNatl Res Counc Can Assoc Comm Sci Criter Environ Qual Publ 0(17583) 1-100 (1980) the Physical-chemical properties, analytical determination & environmental dynamics of phthalate esters (industrial plasticizers) are reviewed.Nat'l Research Council CanadaPhthalate Esters In The Aquatic Environment (1980) NRCC No. 17583For more Special Reports (Complete) data for BUTYL BENZYL PHTHALATE (8 total), please visit the HSDB record page. |
| Brandbekämpfung | Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:Use alcohol-resistant foam, powder, carbon dioxide, water spray. |
| Erste-Hilfe-Maßnahmen | Fresh air, rest.Remove contaminated clothes. Rinse and then wash skin with water and soap.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. |
| Erste Hilfe | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
| Sichere Lagerung | Store in an area without drain or sewer access. Separated from strong oxidants. |
| Firefighting Hazards | Poisonous gases are produced in fire. |
| Expositionsschutz und Persönliche Schutzausrüstung | 20.0 [mg/m3], inhalable fraction[German Research Foundation (DFG)] |
| Brandbekämpfungsverfahren | To fight fire, use spray or mist, carbon dioxide, dry chemical.Water may cause frothing. Use dry chemical, carbon dioxide, or foam extinguishers.From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors, or shows any signs of deforming), withdraw immediately to a secure position.If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire (Material itself does not burn or burns with difficulty.). Use dry chemical or carbon dioxide. Keep run-off water out of sewers and water sources.For more Fire Fighting Procedures (Complete) data for BUTYL BENZYL PHTHALATE (7 total), please visit the HSDB record page. |
| Lagerbedingungen | Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effectsStore in tightly closed containers in a cool, well-ventilated area away from incompatible materials. Metal containers involving the transfer of this chemical should be grounded and bonded. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only nonsparkling tools and equipment, especially when opening and closing containers of this chemical. Sources of ignition such as smoking and open flames are prohibited this chemical is used, handled, or stored in a manner that could create a potential fire or explosion hazard. |
| Reinigungsverfahren | Environmental considerations-land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./Environmental considerations-water spill: Use natural barriers or oil spill control booms to limit spill travel. Remove trapped material with suction hoses.Environmental considerations-air spill: Apply water spray or mist to knock down vapors.ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. For personal protection see section Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal. |
| Freisetung ohne Brand | Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: |
| Entsorgungsverfahren | SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in air, soil or watereffects on animal, aquatic and plant lifeand conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.Incineration: It should be atomized into an incinerator and combustion may be improved by mixing with a more flammable solvent (acetone or benzene).Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging Dispose of as unused product. |
| Verschüttetes entsorgen | Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. |
| Körperbelastung | The mean concentration of butyl benzyl phthalate detected in human adipose tissue in the US was reported as 0.19 ug/g(1). Butyl benzyl phthalate was found in the serum of 2 of 41 young (17-47 months) Puerto Rican girls with premature breast development at 54-117 ug/L(2). The degradation product of butyl benzyl phthalate, monobenzyl phthalate (MBzP), was detected at 13.0-88.7 ug/g creatinine in 97% of 2540 urine samples collected in the United States National Health and Nutrition Examination Survey (1999-2000)(3). MbzP was detected in all 25 samples collected from pregnant New York women at 5.60-120 ug/g creatininesamples were collected Mar to Sept 2000(4). MBzP was detected in >90% of the urine samples collected from 3236 people (ages 6-49 years old) during the Canadian Health Measures Survey 2007-2009(5). MBzP was detected in the serum of 350 of 501 female and 338 of 502 male seniors from Uppsala, Sweden at 0.38-17.3 and 0.41-35.7 mg/mL, respectively(6).The butyl benzyl phthalate degradation product, monobenzyl phthalate (MBzP), was analyzed in urine, breast milk and cord blood to determine exposure(1). Urine samples from 100 pregnant women were collected in the third trimester (Dec 2001-Nov 2002) and MBzP was detected in 64% of the samples at 0.08-235 ug/g. Urine samples from 30 two to three year olds (2003-2004) contained MBzP in 96% of the samples at 0.45-78.13 ug/g. Urine samples from 59 five to six year olds (2006-2007) contained MBzP in 97% of the samples at 0.35-79.10 ug/g. MBzP was detected in 3 of 30 cord blood samples that were collected upon delivery at <0.25-0.70 ug/L. MBzP was also detected in 3 of 30 breast milk samples, from this same population, at <0.25-0.70 ug/L. All samples were collected from residents of central Taiwan(1). |
| Wechselwirkungen | Although risk assessments are typically conducted on a chemical-by-chemical basis, the 1996 Food Quality Protection Act (FQPA) required the Environmental Protection Agency (EPA) to consider cumulative risk of chemicals that act via a common mechanism of toxicity. To this end, we are conducting studies with mixtures to provide a framework for assessing the cumulative effects of "antiandrogenic" chemicals. Rats were dosed during pregnancy with antiandrogens singly or in pairs at dosage levels equivalent to about one half of the ED50 for hypospadias or epididymal agenesis. The pairs include: AR antagonists (vinclozolin plus procymidone), phthalate esters (DBP plus BBP and DEHP plus DBP), a phthalate ester plus an AR antagonist (DBP plus procymidone), and linuron plus BBP. We predicted that each chemical by itself would induce few malformationshowever, by mixing any two chemicals together, about 50% of the males would be malformed. All binary combinations produced cumulative, dose-additive effects on the androgen-dependent tissues. We also conducted a mixture study combining seven "antiandrogens" together. These chemicals elicit antiandrogenic effects at two different sites in the androgen signaling pathway (i.e., AR antagonist or inhibition of androgen synthesis). In this study, the complex mixture behaved in a dose-additive manner. Our results indicate that compounds that act by disparate mechanisms of toxicity display cumulative, dose-additive effects when present in combination. /Mixtures/Butyl benzyl phthalate (BBP), an endocrine disruptor present in the environment, exerts its genomic effects via intracellular steroid receptors and elicits non-genomic effects by interfering with membrane ion-channel receptors. We previously found that BBP blocks the calcium signaling coupled with P2X receptors in PC12 cells (Liu & Chen, 2006). Osteoblast P2X receptors were recently reported to play a role in cell proliferation and bone remodeling. In this present study, the effects of BBP on ATP-induced responses were investigated in human osteosarcoma HOS cells. These receptors mRNA had been detected, named P2X4, P2X7, P2Y2, P2Y4, P2Y5, P2Y9, and P2Y11, in human osteosarcoma HOS cells by RT-PCR. The enhancement of cell proliferation and the decrease of cytoviability had both been shown to be coupled to stimulation via different concentrations of ATP. BBP suppressed the ATP-induced calcium influx (mainly coupled with P2X) and cell proliferation but not the ATP-induced intracellular calcium release (mainly coupled with P2Y) and cytotoxicity in human osteosarcoma HOS cells. Suramin, a common P2 receptor's antagonist, blocked the ATP-induced calcium signaling, cell proliferation, and cytotoxicity. We suggest that P2X is mainly responsible for cell proliferation, and P2Y might be partially responsible for the observed cytotoxicity. BBP suppressed the calcium signaling coupled with P2X, suppressing cell proliferation. Since the importance of P2X receptors during bone metastasis has recently become apparent, the possible toxic risk of environmental BBP during bone remodeling is a public problem of concern.During recent decades the prevalence of IgE-mediated (atopic) allergic diseases in Western Europe and the USA has been increasing dramatically. It has been suggested that one possible cause is the presence in the environment of chemicals that may act as adjuvants, enhancing immune and allergic responses. Certain commonly used phthalate plasticizers such as butyl benzyl phthalate (BBP) have been implicated in this way. In the current experiments, the impact of BBP, applied by a physiologically relevant exposure route, on the vigour of immune responses induced in BALB/c strain mice has been examined. Mice were immunized via subcutaneous injection with the reference allergen ovalbumin (OVA) and received concurrent topical treatment with doses of BBP that induced significant changes in liver weight. The generation of specific anti-OVA IgE and IgG1 antibodies was measured by passive cutaneous anaphylaxis and by enzyme-linked immunosorbant assays, respectively. Topical administration of BBP was without impact on anti-OVA IgE antibody responses, regardless of whether BBP was applied locally or distant to the site of OVA immunization. However, same-site treatment with high-dose BBP (100 mg) did result in a modest elevation in anti-OVA IgG1 antibody production, a subclass of antibody used as a surrogate marker of IgE responses. Taken together with human exposure data, these results suggest that the doses of phthalate encountered in the home environment are unlikely to be a major factor contributing to the increased incidence of asthma and allergy in the developed world. |
| Zielorgane | Hepatic |
| Gesundheitliche Auswirkungen | Phthalate esters are endocrine disruptors. Animal studies have shown that they disrupt reproductive development and can cause a number of malformations in affected young, such as reduced anogenital distance (AGD), cryptorchidism, hypospadias, and reduced fertility. The combination of effects associated with phthalates is called 'phthalate syndrome’. (A2883) |
| Ökotoxizitätswerte | EC50Species: Selenastrum capricornutum (alga)Concentration: 110 ug/L for 96 hrtoxic effect: chlorophyll a /Conditions of bioassay not specified in source examined/Concentration: 130 ug/L for 96 hrtoxic effect: cell number /Conditions of bioassay not specified in source examined/Species: Skeletonema costatum (alga)Concentration: 170 ug/L for 96 hrConcentration: 190 ug/L for 96 hrFor more Ecotoxicity Values (Complete) data for BUTYL BENZYL PHTHALATE (42 total), please visit the HSDB record page. |
| Umweltverhalten | TERRESTRIAL FATE: Based on a classification scheme(1), log Koc values of 3.21-3.997(2-4), indicate that butyl benzyl phthalate is expected to have low to no mobility in soil(SRC). Volatilization of butyl benzyl phthalate from moist soil surfaces is expected(SRC) given an estimated Henry's Law constant of 1.3X10-6 atm-cu m/mole(SRC), based upon its vapor pressure, 8.25X10-6 mm Hg(5), and water solubility, 2.69 mg/L(5). However, adsorption to soil is expected to attenuate volatilization(SRC). Butyl benzyl phthalate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(5). An 80.9% of theoretical BOD using activated sludge in the Japanese MITI test(6) suggests that biodegradation is an important environmental fate process in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), log Koc values of >4.7, measured in suspended solids(2), indicate that butyl benzyl phthalate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 1.3X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 8.25X10-6 mm Hg(4), and water solubility, 2.69 mg/L(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 52 and 380 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The volatilization half-life from a model pond is about 380 years when adsorption is considered(5). The hydrolysis half-life of butyl benzyl phthalate was calculated to be 1.4 years and 51 days at pH values of 7 and 8, respectively(6). According to a classification scheme(7), a BCF of 9.4 in bluegill sunfish(8), suggests bioconcentration in aquatic organisms is low(SRC). Biodegradation in river die-away tests resulted in half-lives of approximately 0.32(9) to 13 days(10), suggesting that biodegradation may be an important environmental fate process in water(SRC).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), butyl benzyl phthalate, which has a vapor pressure of 8.25X10-6 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase butyl benzyl phthalate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 35 hours(SRC), calculated from its rate constant of 1.1X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase butyl benzyl phthalate may be removed from the air by wet and dry deposition(SRC). Butyl benzyl phthalate contains chromophores that absorb at wavelengths >290 nm(4) and, therefore, may be susceptible to direct photolysis by sunlight(SRC). |
| Lebensmitteluntersuchungswerte | Butyl benzyl phthalate was analyzed for, but not detected in vodka(1). The mean butyl benzyl phthalate concentration was reported as 0.039, 0.4, 0.08, 7.4, 0.01, 0.13, 0.04, 0.005 and 0.09 ug/g in beverages, other dairy, eggs, fat and oils, fish, meat, poultry, vegetables and other foods, respectively(2). Food samples collected over four days from University P&M restaurant contained butyl benzyl phthalate at 63.0, 92.3, 3.27, 3.29 and 2.37 ng/g wet weight in lasagne, roast beef, fried vegetables, stewed apples and fruit salad, respectively(3). Butyl benzyl phthalate was not detected (detection limit 2 ng/g wet weight) in fish terrine, mixed salad, corn salad, radishes, chicken leg, mixed steak, Basmati rice, fried potatoes, plain yogurt, Gruyere cheese, Camembert cheese, granny apple or black grapes(3). |
| Unerwünschte Wirkungen | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. |
| Expositionspfade | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.Oral (L1208)inhalation (L1208)dermal (L1208) |
| Milk Concentrations | ENVIRONMENTAL: The mean concentration of butyl benzyl phthalate in dairy milk and infant formula powder was 0.0012 and 0.044 ug/g, respectively(1). |
| Toxizitätsübersicht | Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.orgIDENTIFICATION AND USE: Butyl benzyl phthalate (BBP) is a clear oily liquid that is used as a plasticizer mainly in polyvinyl chloride for vinyl floor tile, vinyl foams and carpet backing and in cellulose plastics and polyurethane. HUMAN EXPOSURE AND TOXICITY: BBP was not observed to be a primary irritant or sensitizer in skin patch tests with volunteers. Prenatal exposure to BBP may influence the risk of developing eczema in early childhood. BBP was also positively associated with airway inflammation in children. BBP was positive in E-Screen assay used to measure the proliferation of MCF-7 cells, a human breast cancer cell line. In another study proteomic changes in proteins secreted by human hepatocellular carcinomas (HepG2) cells exposed to BBP were evaluated. These proteins were found to be involved in apoptosis, signaling, tumor progression, energy metabolism, and cell structure and motility. BBP treatment of plasmacytoid DC cells suppressed IFN-gamma but enhanced IL-13 production by CD4+ T cells. ANIMAL STUDIES: The acute toxicity of this compound is low, with oral LD50 values in rats being greater than 2 g/kg body weight. Target organs following acute exposure include the hematological and central nervous systems. Repeated dose toxicity studies of this compound in the rat show decreases in body weight gain and increases in organ to body weight ratios, particularly for the kidney and liver. Histopathological effects on the pancreas and kidney and hematological effects have also been observed. At higher doses, degenerative effects on the testes and, occasionally histopathological effects on the liver have been reported. In specialized investigations, peroximal proliferation in the liver has been noted. The chronic toxicity and carcinogenicity of BBP bioassays in rats and mice, indicated that there was some evidence of carcinogenicity in male rats, based on an increased incidence of pancreatic tumors, and equivocal evidence in female rats, based on marginal increases in pancreatic and bladder tumors. Dietary restriction prevented full expression of the pancreatic tumors. There was no evidence for the carcinogenicity of BBP in mice. BBP is not genotoxic. In a range of studies, including those designed to investigate the reproductive effects of BBP on the testes and endocrine hormone in male rats, a modified mating protocol and a one generation study, adverse effects on the testes and, consequently fertility have generally been observed only at doses higher than those that induce effects on other organs (such as the kidney and liver), although decreases in sperm counts have been observed at doses similar to those that induce effects in the kidney and liver. Reduction in testes weight and daily sperm production in the offspring were reported at relatively low level in rats exposed in utero and during lactation. Neither BBP nor its principal metabolites have been uteritrophic in vivo in rats or mice, In several well conducted studies in rats and mice, butyl benzyl phthalate induced marked developmental effects, but only at dose levels that induce significant maternal toxicity. BBP administration disrupts normal learning and social behavior in rats, and these effects could be related to alterations of amygdala function. ECOTOXICITY STUDIES: A range of toxicity tests with aquatic organisms has indicated the adverse effects occur at exposure concentrations greater than 100 ug/L. Behavioral changes in fish were noted after sublethal BBP exposure.Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expression. Some phthalates have also been shown to reduce the expression of insulin-like peptide 3 (insl3), an important hormone secreted by the Leydig cell necessary for development of the gubernacular ligament. Animal studies have shown that these effects disrupt reproductive development and can cause a number of malformations in affected young. (A2883) |
| Average Daily Intake | The average daily intake of butyl benzyl phthalate was estimated as 0.085 ug/kg/day based on a food survey conducted in Albany, NY in 2011(1). The median concentration of monobenzyl phthalate in urine samples from 36 Japanese people collected May to June 2004 was 2.4 ug/Lthis translates to an exposure rate of 0.074-0.11 ug/kg/day of the parent compound butyl benzyl phthalate(2). Based on analysis of urine samples from the German population, the average daily intake of butyl benzyl phthalate was 0.2-9.2, 0.2-6.8 and 0.2-4.5 ug/kg body weight/day in children, females and males, respectively(3). |
| TSCA-Anforderungen | Pursuant to section 8(d) of TSCA, EPA promulagated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Butyl benzyl phthalate is included on this list. Effective date 04/29/83Sunset date 04/29/93. |
| CERCLA-Meldepflichtmengen | Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 100 lb or 45.4 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). |
| Landesrichtlinien für Trinkwasser | (MN) MINNESOTA 100 ug/L(FL) FLORIDA 140 ug/L |
| Wassergefährdungsklasse (WGK) | 2 |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | UN 3082 9/PG 3 |
| Zollcode | 29173400 |
| RTECS-Nr. | TH9990000 |
| R-Sätze (R) | 61-50/53-62 |
| Toxizität | Acute oral LD50 for guinea pigs 13,750 mg/kg, mice 4,170 mg/kg, rats 2,330 mg/kg (quoted, RTECS, 1985). |
| Gefahrensymbole | T,N |
| Sicherheitshinweise (S) | 53-45-60-61 |
| Gefahrenklasse | 9Aquatic Acute 1Aquatic Chronic 1Repr. 1B |
| Verpackungsgruppe | III |
| Lagerklasse | 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects |
| Gefahrstoffdaten | 85-68-7(Hazardous Substances Data) |
| Selbstentzündungstemperatur | 450 °F |
Anwendungen & Verwendung
Verwenden
A phthalate metabolite with genotoxic effect.