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HCID 2350Erstellt: 26. Oktober 2026

4-((4-Chlorophenyl)-2-pyridinylmethoxy)-1-piperidinebutanoic Acid

rac Bepotastine · Rac-Bepotastine-d6 · YWGDOWXRIALTES-UHFFFAOYSA-N · 4-[(4-Chlorophenyl)-2-pyridinylmethoxy]-1-piperidinebutanoic acid · 1-Piperidinebutanoic acid, 4-[(4-chlorophenyl)-2-pyridinylmethoxy]-

https://huagongshe.com/de/chemical/2350

Molekülstruktur von 4-((4-Chlorophenyl)-2-pyridinylmethoxy)-1-piperidinebutanoic Acid

Identifikatoren & physikalische Daten

CAS No.1070505-53-1
SummenformelC21H25ClN2O3
Durchschnittliche Molmasse388,9 g/mol
Monoisotopische Masse388,15537034 g/mol
SMILESO=C(O)CCCN1CCC(OC(c2ccc(Cl)cc2)c2ccccn2)CC1
InChIKeyYWGDOWXRIALTES-UHFFFAOYSA-N
PubChem CID2350
ChEMBLCHEMBL4877190
DTXSIDDTXSID70869727

Chemische & physikalische Eigenschaften

XLogP1
Polarare Oberfläche (TPSA)62,7
H-Brücken-Donoren1
H-Brücken-Akzeptoren5
Frei drehbare Bindungen8
Schwere Atome27
Formalladung0
Komplexität449
Löslichkeit5.03e-02 g/L
Physical DescriptionSolid
Dichte1.26

Sicherheit & Vorschriften

ExpositionspfadeOral, Ophthalmic. Tmax, after single dose, opthalmic = 1.2 hoursCmax, 1.5%, opthalmic dose = 7.3 &#1771.9 ng/mLAfter 24 hours post-installation, levels of bepotastine are below quantifiable limit of 2 ng/mL. Minimal systemic absorption with opthalmic dosage form.
ToxizitätsübersichtBecause of a type 1 hypersensitivity reaction cascade that is triggered by antigen exposure, allergic conjunctivitis occurs. Allergen exposure is followed by conjunctival mast cell degranulation and histamine released as a result of the formation of complementary IgE cross-links on the conjunctiva. Due to the release of histamine, symptoms such as itching can be observed. Bepotastine works to relieve itchy eyes by three primary mechanisms of action. It is a non-sedating, selective antagonist of the histamine 1 (H1) receptor, a mast cell stabilizer, and it suppresses the migration of eosinophils into inflamed tissues to prevent tissue damage and worsening of allergic inflammation of the conjunctiva.
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
4-((4-Chlorophenyl)-2-pyridinylmethoxy)-1-piperidinebutanoic Acid｜Huagongshe