(S)-Lisofylline
(S)-Lisofylline · (S)-Lisophylline · (S)-Lisofylline Exclusive · (S)-Lisofylline, 10 mM in DMSO · (S)Lisofylline,(S) Lisofylline · 1-[(5S)-5-hydroxyhexyl]-3,7-dimethylpurine-2,6-dione · 1H-Purine-2,6-dione, 3,7-dihydro-1-[(5S)-5-hydroxyhexyl]-3,7-dimethyl-
Identifikatoren & physikalische Daten
| CAS No. | 100324-80-9 |
|---|---|
| Summenformel | C13H20N4O3 |
| Durchschnittliche Molmasse | 280,32 g/mol |
| SMILES | C[C@H](O)CCCCn1c(=O)c2c(ncn2C)n(C)c1=O |
| InChIKey | NSMXQKNUPPXBRG-VIFPVBQESA-N |
| PubChem CID | 23519621 |
| ChEMBL | CHEMBL4300766 |
| ChEBI | CHEBI:143564 |
Chemische & physikalische Eigenschaften
| Lagerbedingungen | Store at -20°C |
|---|---|
| Löslichkeit | ≤15mg/ml in ethanol3mg/ml in DMSO12mg/ml in dimethyl formamide |
| Aggregatzustand | crystalline solid |
| Farbe | Off-white to light yellow |
Anwendungen & Verwendung
Beschreibung
LSF, a chiral metabolite of pentoxifylline, acts as a potent anti-inflammatory agent. (S)-LSF is the pharmacologically inactive optical enantiomer of (R)-LSF, the biologically active isomer. When metabolized by isolated human liver cells, pentoxifylline is exclusively reduced to (S)-LSF in the cytosol, while reduction in liver microsomes is 85% stereoselective in favor of (S)-LSF formation. Thus, pentoxifylline is an inefficient prodrug for the delivery of therapeutically relevant lisofylline.
Verwenden
LSF, a chiral metabolite of pentoxifylline, acts as a potent anti-inflammatory agent. (S)-LSF is the pharmacologically inactive optical enantiomer of (R)-LSF, the biologically active isomer. When metabolized by isolated human liver cells, pentoxifylline is exclusively reduced to (S)-LSF in the cytosol, while reduction in liver microsomes is 85% stereoselective in favor of (S)-LSF formation. Thus, pentoxifylline is an inefficient prodrug for the delivery of therapeutically relevant lisofylline.[Cayman Chemical]