Tegoprazan
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Grundinformationen
- CAS
942195-55-3- Standard-SMILES
Cc1nc2c(O[C@H]3CCOc4cc(F)cc(F)c43)cc(C(=O)N(C)C)cc2[nH]1- InChIKey
CLIQCDHNPDMGSL-HNNXBMFYSA-N- Summenformel
- C20H19F2N3O3
- Durchschnittliche Molmasse
- 387,4 g/mol
- Monoisotopische Masse
- 387,1394478
Namen und Bezeichner
- Bevorzugter Name
- Tegoprazan
- IUPAC
- 7-[[(4S)-5,7-difluoro-3,4-dihydro-2H-chromen-4-yl]oxy]-N,N,2-trimethyl-3H-benzimidazole-5-carboxamide
- Englischer Name
- Tegoprazan
- Summenformel
- C20H19F2N3O3
- Molmasse
- 387.38
Namen und Synonyme
Tegoprazan942195-55-3CJ-12420LXI-15028W017G7IF4S7-[[(4S)-5,7-difluoro-3,4-dihydro-2H-chromen-4-yl]oxy]-N,N,2-trimethyl-3H-benzimidazole-5-carboxamideK-CAB(S)-4-((5,7-Difluorochroman-4-yl)oxy)-N,N,2-trimethyl-1H-benzo[d]imidazole-6-carboxamide(S)-4-((5,7-difluorochroman-4-yl)oxy)-N,N,2-trimethyl-1H-benzo(d)imidazole-6-carboxamide1H-Benzimidazole-5-carboxamide, 7-(((4S)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-yl)oxy)-N,N,2-trimethyl-7-(((4S)-5,7-Difluoro-3,4-dihydro-2H-chromen-4-yl)oxy)-N,N,2-trimethyl-1H-benzimidazole-5-carboxamidetegoprazanum
Weitere Namen anzeigen
RQ-4CJ 12420TigorasanTegolazanRQ-00000004For GorazanTegopmsam Al
1H-Benzimidazole-5-carboxamide, 7-[[(4S)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-yl]oxy]-N,N,2-trimethyl-7-(((4S)-5,7-difluoro-3,4-dihydro-2H-chromen-4-yl)oxy)-N,N,2-trimethyl-3H-benzimidazole-5-carboxamideRefChem:187715Tegoprazan [INN]7-[[(4S)-5,7-Difluoro-3,4-dihydro-2H-1-benzopyran-4-yl]oxy]-N,N,2-trimethyl-1H-benzimidazole-5-carboxamideGTPL12008EX-A4304Tegoprazan (INN)
Datenbank-Bezeichner
- CAS
942195-55-3- PubChem CID
- 23582846
- ChEMBL
CHEMBL4297583- UNII
- W017G7IF4S
- Nikkaji
- J3.781.706F
Eigenschaften
Berechnete StruktureigenschaftenWird ergänzt
- XLogP
- 3,2
- Polarare Oberfläche (TPSA)
- 67,5 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 6
- Frei drehbare Bindungen
- 3
- Schwere Atome
- 28
- Formalladung
- 0
- Komplexität
- 581
Physikochemische Eigenschaften
- Siedepunkt
- 596.5 · 596.5±50.0 °C(Predicted)
- Dichte
- 1.371 · 1.371±0.06 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- Löslichkeit
- DMSO: soluble
- Aggregatzustand
- A solid
- pka
- 9.73 · 9.73±0.30(Predicted)
- Farbe
- Off-white to light yellow
- InChI
- InChI=1S/C20H19F2N3O3/c1-10-23-14-6-11(20(26)25(2)3)7-17(19(14)24-10)28-15-4-5-27-16-9-12(21)8-13(22)18(15)16/h6-9,15H,4-5H2,1-3H3,(H,23,24)/t15-/m0/s1
- InChIKey
- CLIQCDHNPDMGSL-HNNXBMFYSA-N
- SMILES
- C1(C)NC2=C(O[C@@H]3C4=C(F)C=C(F)C=C4OCC3)C=C(C(N(C)C)=O)C=C2N=1
Chemie und Industrie
Pharmakologische Informationen
ATC Code
A - Alimentary tract and metabolism；A02 - Drugs for acid related disorders；A02B - Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord)；A02BC - Proton pump inhibitors；A02BC09 - Tegoprazan
QA - Alimentary tract and metabolism；QA02 - Drugs for acid related disorders；QA02B - Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord)；QA02BC - Proton pump inhibitors；QA02BC09 - Tegoprazan
Mechanism of Action
Tegoprazan works as a potassium-competitive acid blocker that is potent and highly selective. Its mechanism of action is different from that of the proton-pump inhibitors as this drug does not require conversion into an active form and can directly inhibit H+/K+‐ATPase in a reversible and K+‐competitive way. This is because it is an acid-resistant weak base with the ability to remain in the highly acidic canaliculi of gastric parietal cells.
Anwendungen
VerwendenTegoprazan is used for remedying and treating nocturnal acid breakthrough symptoms, such as GERD, ulcer, Barrett''s esophagus, and heartburn.
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