Δ2-Cefepime
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Grundinformationen
- CAS
88040-25-9- Standard-SMILES
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])C(C[N+]3(C)CCCC3)=CS[C@H]12)c1csc(N)n1- Summenformel
- C23H34N6O6S2
- Durchschnittliche Molmasse
- 554,6827 g/mol
Namen und Bezeichner
- Bevorzugter Name
- Δ2-Cefepime
- Englischer Name
- Δ2-Cefepime
- Summenformel
- C23H34N6O6S2
- Molmasse
- 554.68266
Namen und Synonyme
Δ2-CefepiMe EtherateΔ2-CefepimeDelta2-CefepimeCefepime Δ - 3 IsomerCefepime Δ - 3 Isomerδ2-Cefepime Etherate, CAS 88040-25-9Δ2-CefepiMe Etherate Dihydrochloride Salt1-[[(6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-en-3-yl]Methyl]-1-MethylpyrrolidiniuM Inner Salt Etherate(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylate,ethoxyethane
Datenbank-Bezeichner
- CAS
88040-25-9- PubChem CID
- 23659442
- UNII
- S83TB3X2CL
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 151 °C · >151°C (dec.)
- storage temp.
- -20 °C · Amber Vial, -20°C Freezer, Under Inert Atmosphere
- Löslichkeit
- Water (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- InChIKey
- DBCVQAGQPYVVDA-XVKMNWMGSA-N
Chemie und Industrie
Anwendungen
VerwendenΔ2-Cefepime is the Δ2-isomer of Cefepime (C242750), a new series of cephalosporins.
Darstellung
synthetischeFirst, cefepime and N-trimethylsilylacetamide were added to dichloromethane for 0.5 h. Subsequently, triethylamine dissolved in dichloromethane was added to the reaction system between 2-5 °C. Adjust the temperature to 2-5 °C and react for 24 h. After adding water, the aqueous layer was separated, and the aqueous phase was washed with methylene chloride. Wait for the solution to cool to 2-5 °C and adjust the pH=3 with sulfuric acid. Stir the resulting slurry for 2h. Filter to collect the solids and wash with water, adjust the pH=7.5-8.0 with sodium bicarbonate aqueous solution, add carbon, and stir for 30 min. Filter the mixture to collect the filtrate and adjust pH=3 with sulfuric acid. Finally, the solids are filtered and collected, and product Δ2-Cefepime is obtained by washing and drying.
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