Natriumoleat

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Dust mask and gloves (USCG, 1999)

... /NIOSH approved respirator/ and gloves.

The CIR Expert Panel concluded that the following ingredients are safe in the present practices of use andconcentration described in the safety assessment when formulated to be non-irritating and non-sensitizing, which may be basedon a QRA...Sodium Oleate...

Safe for use in cosmetics, with qualifications

...0.05 ML OF 10% SOLN OF SODIUM OLEATE ADJUSTED WITH HYDROCHLORIC ACID TO PH 7.2 INJECTED INTO CORNEAS OF RABBITS CAUSED EYES TO BECOME INFLAMED WITHIN FEW HR & DEVELOP CORNEAL ABSCESS WITHIN FEW DAYS. EYES ULTIMATELY BECAME EXTENSIVELY SCARRED & VASCULARIZED.

IP OR IV ADMIN OF 0.1 NORMAL SODIUM OLEATE INTO RATS SIGNIFICANTLY SUPPRESSED THE VOLUME OF GASTRIC SECRETION AS COMPARED TO NORMAL SALINE CONTROLS.

Sodium oleate was added to the drinking water of groups of 50 male and 50 female F344 rats at levels of 2.5 and 5.0% for 108 weeks. The mean liver weight in males given 5% oleate was lower than that of the males given 2.5% oleate or distilled water alone. The mean thymus weight of females given 5% oleate was higher than that of females given 2.5% oleate or distilled water. There were no statistically significant differences between treated and controls rats in the results of the urine and serum analyses or hematological determinations or in the incidence of tumors, apart from pancreatic tumors. The latter, in the males, showed some increase over the concurrent controls but did not differ significantly from the reported spontaneous incidence in this strain. It was concluded that sodium oleate does not induce tumors when given orally to F344 rats.

Four commercial emulsifiers, sodium oleate, sodium stearate, sodium stearoyl-2-lactylate, and calcium stearoyl-2-lactylate, were evaluated for their effectiveness as inhibitors of Pseudomonas lipases. Each emulsifier was incubated at 0.5, 1.0, and 2.0% concn with the individual as well as a mixture of the crude lipase extracts obtained from three Pseudomonas species (Pseudomonas fluorescens, Pseudomonas putida, and Pseudomonas cepacia), in reconstituted nonfat dry milk (10%) for 30 min. At a 2% concn, all emulsifiers tested were potent inhibitors (100%) of lipase activity. The effectiveness of lipolysis inhibition declined with decreasing emulsifier concn. Sodium oleate demonstrated significant (p < 0.05) lipolysis inhibition at a 1% concn regardless of initial lipase level. Synergism in inhibiting lipolytic activity between these selected emulsifiers was not evident.

/SIMPLE HOUSEHOLD SOAPS SUCH AS SODIUM OLEATE/...ARE...LESS LETHAL THAN SYNTHETIC ANIONIC DETERGENTS & EVEN LESS THAN MOST NONIONIC DETERGENTS. ... SOAPS WITH AN APPRECIABLE CONTENT OF FREE ALKALI (EG SOME LAUNDRY SOAPS) ARE LESS BENIGN. /SOAPS/

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Sodium oleate is found on List D. Case No: 4083; Pesticide type: insecticide, fungicide, herbicide, rodenticide, antimicrobial; Case Status: RED Approved 09/92; OPP has made a decision that some/all uses of the pesticide are eligible for registration, as reflected in a Reregistration Eligibility Decision (RED) document.; Active ingredient (AI): Sodium oleate; AI Status: The active ingredient is no longer contained in any registered pesticide products ... "cancelled."