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HCID 23667635Erstellt: 27. Oktober 2026

Natriumperiodat

NaIO4 · SODIUM METAPERIODATE · metaperiodate · SODIUM M-PERIODATE · Sodium metapriodate · IONAM · Sodium periodate · Periodate sodium

https://huagongshe.com/de/chemical/23667635

Molekülstruktur von Natriumperiodat

Identifikatoren & physikalische Daten

CAS No.7790-28-5
SummenformelNa.I.O4
Durchschnittliche Molmasse213,892 g/mol
Monoisotopische Masse213,87390076 g/mol
SMILES[Na+].[O-][I+3]([O-])([O-])[O-]
InChIKeyJQWHASGSAFIOCM-UHFFFAOYSA-M
PubChem CID23667635
ChEBICHEBI:75226
EC No.232-197-6
DTXSIDDTXSID30894075
Lokaler NameNatriumperiodat

Chemische & physikalische Eigenschaften

Polarare Oberfläche (TPSA)74,3
H-Brücken-Donoren0
H-Brücken-Akzeptoren4
Frei drehbare Bindungen0
Schwere Atome6
Formalladung0
Komplexität118
StoffklassenOther Classes -> Halogens, Inorganic Compounds
Dichte3.865 at 16 °CWhite, efflorescent, trigonal crystalsdensity 3.219 at 18 °Cdecomposes at 175 °C1 gm dissolves in 8 ml water at 20 °C /Trihydrate/3.865 @25 °C
Color/FormWhite, tetragonal crystals
LöslichkeitSoluble in cold water, sulfuric, nitric, acetic acidsH2O: 0.5 M at 20 °C, clear, colorless80 g/L (20 ºC)
SiedepunktDecomposes approx 300 °C300°C
DecompositionWhen heated to decomposition it emit toxic fumes of /hydrogen iodide and sodium oxide/.
Physical DescriptionWhite solid[Merck Index] Colorless odorless powder[MSDSonline]
Schmelzpunkt300 °C (dec.) (lit.)
Dampfdruck0Pa at 20℃
LagerbedingungenStore at +5°C to +30°C.
AggregatzustandSolid
Wichte4.174
FarbeWhite to almost white
GeruchOdorless
pH3.5-5.5 (25℃, 0.5M in H2O)
Merck14,8640
StabilitätStable. Incompatible with organic materials, combustible materials. Forms explosive mixtures with reducing agents, finely powdered metals, magnesium.
InChI1S/HIO4.Na/c2-1(3,4)5/h(H,2,3,4,5)/q+1/p-1
InChIKeyJQWHASGSAFIOCM-UHFFFAOYSA-M
SMILES[Na+].[O-]I(=O)(=O)=O
LogP (Verteilungskoeffizient)-1 at 20℃
CAS Datenbank7790-28-5(CAS DataBase Reference)
EPA chemische InformationenPeriodic acid (HIO4), sodium salt (7790-28-5)
Absorptioncut-off at 350nm in H2O at 0.05M

Sicherheit & Vorschriften

GHS-EinstufungDangerH271 (54.1%): May cause fire or explosionstrong Oxidizer [Danger Oxidizing liquidsOxidizing solids]P210, P220, P260, P261, P264, P264+P265, P270, P271, P273, P280, P283, P301+P316, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P306+P360, P316, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P370+P378, P371+P380+P375, P391, P403+P233, P405, P420, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 320 reports by companies from 29 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H272: May intensify fireoxidizer [Danger Oxidizing liquids
Regulatorische InformationenChemical: Periodic acid (HIO4), sodium saltStatus: Active Update: 30-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/5745Periodic acid, sodium salt: HSNO Approval: HSR001353 Approved with controls
Weitere SicherheitsinformationenIMAP assessments - Periodic acid and its salts: Human health tier II assessment
GefahrenübersichtA strong oxidizer[ChemIDplus] May cause skin, eye, and respiratory tract irritation[HSDB] An eye and mild skin irritant[eChemPortal: ERMA] May cause fire on contact with combustible materialAn irritant[MSDSonline] See Metaperiodic acid.
Hazard Classes and CategoriesOx. Sol. 1 (54.1%)Acute toxicity (ingestion) - category 4Oxidizing solids - Category 2
Skin, Eye, and Respiratory IrritationsEye Contact: May cause irritation, redness and pain.Inhalation: May irritate the respiratory tract, with symptoms of coughing and possible shortness of breath.
EntsorgungsverfahrenSRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality

Anwendungen & Verwendung

Beschreibung

Sodium periodate is an inorganic salt, composed of a sodium cation and the periodate anion. It may also be regarded as the sodium salt of periodic acid. Like many periodates it can exist in two different forms: sodium metaperiodate, which has the formula NaIO4, and sodium orthoperiodate, normally this means sodium hydrogen periodate (Na2H3IO6) but the fully reacted sodium orthoperiodate salt, Na5IO6, can also be prepared. Both salts are useful oxidising agents.

Verwenden

Sodium Periodate is the sodium salt of periodic acid used to oxidize cellulose. Sodium Periodate oxidation is often used to selectively label RNA, saccharides and other compounds with vicinal diols.

potential migration in soil or water
effects on animal, aquatic, and plant life
and conformance with environmental and public health regulations.
Protective Action Criteria (PAC)0.19 [mg/m3]2.1 [mg/m3]13 [mg/m3]
WechselwirkungenHuman peripheral blood mononuclear cells when activated with the oxidizing mitogens, neuraminidase/galactose oxidase or sodium periodate, express cytolytic activity for freshly isolated tumor cells and for a variety of cell lines, including NK-resistant solid tumor lines. Normal lymphoid cells are not targets for cytotoxicity and do not inhibit lysis of susceptible targets mediated by the oxidizing mitogen-activated mononuclear cells. The cytotoxic response is rapidly generated and reaches peak levels at 48 hr. The oxidizing mitogens induce expression of IL 2 receptors on peripheral blood mononuclear cells. Combined treatment of cells with IL 2 and the oxidizing mitogens results in a marked enhancement of cytotoxicity. Enhancement is achieved at levels of IL 2 that alone result in minimal generation of cytotoxic cells.
Human Toxicity Excerpts/SIGNS and SYMPTOMS/ Inhalation: May irritate the respiratory tract, with symptoms of coughing and possible shortness of breath./SIGNS and SYMPTOMS/ Ingestion: May cause gastrointestinal upset with symptoms of abdominal pain, vomiting, and diarrhea./SIGNS and SYMPTOMS/ Skin Contact: Possible irritation or reddening of moist skin on prolonged contact. Eye Contact: May cause irritation, redness and pain./OTHER TOXICITY INFORMATION/ Chronic Exposure: Repeated ingestions may cause kidney dysfunction or failure and blood conditions such as hemolysis. Central nervous system may be affected.
Non-Human Toxicity Excerpts/ALTERNATIVE IN VITRO TESTS/ Sodium periodate treated lymphocytes engage in cell to cell interaction and also yield a soluble growth factor that stimulates DNA synthesis when added to naive autologous cells. Adherent cells enhance the factor mediated activity. Sodium periodate stimulated lymphocytes, treated with mitomycin C, produced no growth factor activity. Partial characterization of the factor indicates that it is non-dialyzable, resistant to ribonuclease, and sensitive to heat, trypsin, and papain./ALTERNATIVE IN VITRO TESTS/ T lymphocytes oxidized with the mitogen sodium periodate undergo a proliferative response when cultured in the presence of Ia+ accessory cells. ... /The authors/ have evaluated the role of Ia and the requirement for interleukin 1 (IL 1) in periodate mitogenicity by using the Ia+ cloned tumor cell lines P388AD (Ia+, IL 1 inducible) and P388NA (Ia+, IL 1 noninducible) as accessory cells. P388AD but not P388NA was able to supply accessory cell function to periodate-treated T cells, suggesting that Ia expression alone was not sufficient to reconstitute a response. Monoclonal anti-I-Ad and anti-I-Ed antibody blocked the accessory cell function of P388AD. In addition, monoclonal antibody GK 1.5, directed against the T cell determinant L3T4a, blocked the P388AD/periodate-treated T cell interaction, confirming that this interaction was restricted by class II molecules. Although Ia expression was required, the response was not major histocompatibility complex (MHC) restricted, because allogeneic as well as syngeneic macrophages were capable of supplying accessory cell function to periodate-treated T cells. Exogenous IL 1 alone was able to trigger periodate-treated T cells, suggesting that Ia was required for the induction of IL 1 synthesis by the accessory cells. Furthermore, purified IL 2, devoid of IL 1 activity, was able to fully reconstitute the proliferative response of accessory cell-depleted oxidized T cells to a level equal to that of whole spleen accessory cells or P388AD. These data suggest that periodate-treated T cells can proliferate with IL 1 alone and that Ia+ accessory cells in periodate-mediated T cell mitogenicity may function in the release of IL 1 and the induction of IL 2 synthesis by the T cells./OTHER TOXICITY INFORMATION/ Animal experiments suggest a potential for kidney and blood cell damage, similar to that of the bromates and chlorates.
Populations at Special RiskAggravation of Pre-existing Conditions: Persons with impaired liver or kidney function may be more susceptible to the effects of this substance.
Antidote and Emergency TreatmentBasic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/
Non-Human Toxicity ValuesLD50 Mouse intraperitoneal 58 mg/kg
F8
Wassergefährdungsklasse (WGK)3
TSCA-Inventar-StatusTSCA listed
UN-TransportnummerUN 3087 5.1/PG 2
Zollcode28299080
RTECS-Nr.SD4550000
R-Sätze (R)8-22-36/37/38-20/21/22-50-48/25-34
GefahrensymboleO,Xn,Xi,N,C,T
Sicherheitshinweise (S)26-36/37/39-17-61-45-37
Gefahrenklasse5.1Aquatic Acute 1Aquatic Chronic 1Eye Dam. 1Ox. Sol. 1Skin Corr. 1CSTOT RE 1
VerpackungsgruppeII
Lagerklasse5.1A - Strongly oxidizing hazardous materials
Gefahrstoffdaten7790-28-5(Hazardous Substances Data)