Potassium Cyclamate
Grundinformationen
- CAS
7758-04-5- Standard-SMILES
O=S(=O)([O-])NC1CCCCC1.[K+]- InChIKey
PALPTWOXTUVPKA-UHFFFAOYSA-M- Summenformel
- C6H12KNO3S
- Durchschnittliche Molmasse
- 217,33 g/mol
- Monoisotopische Masse
- 217,0174959
Namen und Bezeichner
- Bevorzugter Name
- Potassium Cyclamate
- IUPAC
- potassium N-cyclohexylsulfamate
Namen und Synonyme
POTASSIUM CYCLAMATEPotassium cyclohexylsulfamateCyclamate potassiumMonopotassium cyclohexylsulfamateMonopotassium cyclohexanesulfamate7758-04-50DS7R9NQB0Potassium cyclohexanesulfamatePotassium cyclohexyl sulfamatePotassium N-cyclohexylsulfamateCyclohexanesulfamic acid, monopotassium saltSulfamic acid, cyclohexyl-, monopotassium salt
Weitere Namen anzeigen
DTXSID60228248Cyclamate, PotassiumRefChem:175452DTXCID80150739HSDB 1239N-Cyclohexylsulfamate de potassium [French]UNII-0DS7R9NQB0potassium;N-cyclohexylsulfamate
Datenbank-Bezeichner
- CAS
7758-04-5- PubChem CID
- 23675766
- DTXSID
DTXSID60228248- UNII
- 0DS7R9NQB0
- Nikkaji
- J1.561.357B
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 77,6 Ų
- H-Brücken-Donoren
- 1
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 2
- Schwere Atome
- 12
- Formalladung
- 0
- Komplexität
- 205
Experimentelle und physikochemische Eigenschaften
Chemical ClassesOther Uses -> Food Additives
TasteSWEET TASTE
Food AdditivesNON-NUTRITIVE SWEETENER -> FDA Substance added to food
Color/FormCRYSTALS
Physical DescriptionSolid; [HSDB]
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Gefahrenhinweise
Hazards Summary
After very high oral doses, dogs and cats have vomiting; About 20-40% of cyclamate is absorbed; Gut bacteria convert some of cyclamate into cyclohexylamine which is almost completely absorbed and excreted in urine; [HSDB] See Cyclamic acid. See Sodium cyclamate.
Toxikologische Informationen
Human Toxicity Excerpts
HUMAN SUBJECTS HAVE CONSUMED 5 TO 12 G/DAY FOR SEVERAL WEEKS; THE ONLY NOTED EFFECT WAS A CHANGE IN STOOLS TO A MUSHY CONSISTENCY. NOT ALL SUBJECTS HAD INCREASED FREQUENCY OF BOWEL MOVEMENTS, BUT IN SOME, CATHARTIC ACTION MAY BE DUE TO OSMOTIC FLUID RETENTION BY UNABSORBED CYCLAMATE. /SODIUM CYCLAMATE/
3 PT DESCRIBED DEVELOPED VESICAL CARCINOMA OF BLADDER AFTER PROLONGED PERIOD OF INGESTION OF UNUSUALLY HIGH AMT OF CYCLAMATE SWEETNER, SEVERITY APPEARED IN PROPORTION TO DOSE INGESTED.
THE LACK OF ASSOCIATION BETWEEN SACCHARIN, CYCLAMATE, & HUMAN BLADDER CANCER IS DISCUSSED. /PRC- CONTROVERSIAL/
IN VIVO, CYCLAMATE IS CONVERTED INTO CYCLOHEXYLAMINE WHICH PER SE OR AFTER BIOTRANSFORMATION MAY PROVIDE AN ULTIMATE CARCINOGEN. /CYCLAMATE/
Non-Human Toxicity Excerpts
/ACUTE ORAL DOSES 10-17 G/KG IN MICE/...SHOW ONLY INTESTINAL FLUID ACCUMULATION & SLIGHT CARDIAC DISTENSION WITH DEATH OCCURRING IN 1 TO 24 HR. IV ADMIN OF 4-5 G/KG PRODUCES RAPID EXITUS APPARENTLY IN RESPIRATORY FAILURE. VOMITING OCCURS IN DOGS & CATS AFTER LARGE ORAL DOSES. /SODIUM CYCLAMATE/
Chemie und Industrie
Pharmakologische Informationen
Metabolism/Metabolites
...BIOTRANSFORMATION IN RATS...IS BROUGHT ABOUT BY GUT MICROFLORA. ...GUT MICROFLORA IN MAN & IN ANIMALS ACQUIRE CAPACITY TO METABOLIZE CYCLAMATE INTO CYCLOHEXYLAMINE, WHEN CYCLAMATE IS ADMIN CHRONICALLY. /CYCLAMATE/
GUT MICRO-ORGANISMS, WHICH BECOME CYCLAMATE "CONVERTERS" ARE CLOSTRIDIA IN RATS, ENTEROBACTERIA IN RABBITS, & ENTEROCOCCI IN MAN. /CYCLAMATE/
MeSH Pharmacological ClassificationSubstances that sweeten food, beverages, medications, etc., such as sugar, saccharine or other low-calorie synthetic products. (From Random House Unabridged Dictionary, 2d ed)
Absorption, Distribution and Excretion
...CYCLOHEXYLAMINE FORMED IN INTESTINE IS ALMOST COMPLETELY ABSORBED & EXCRETED IN URINE, IN COMPARISON TO CYCLAMATE, WHICH IS ABSORBED TO AN EXTENT OF ONLY 20-40%. /CYCLAMATE/
...(14)C-CYCLAMATE, GIVEN IV TO WOMEN UNDERGOING THERAPEUTIC ABORTION, BY ABDOMINAL HYSTERECTOMY DURING EARLY PREGNANCY, CROSSED PLACENTA & DISPERSED IN FETAL TISSUES, PARTICULARLY IN LIVER, SPLEEN, PANCREAS, & KIDNEYS. ...MATERNAL BLOOD LEVELS...FELL RAPIDLY...INDICATING VERY RAPID ELIMINATION... /CYCLAMATE/
MAX DAILY EXCRETION OF CYCLOHEXYLAMINE...RANGED FROM 0.1 TO 0.9% OF DAILY CYCLAMATE INTAKE (5 G); URINARY OUTPUT OF CYCLOHEXYLAMINE WAS ERRATIC & CONTINUED FOR 3-4 DAYS AFTER ADMIN HAD CEASED. /CYCLAMATE/
Verwendung und Herstellung
Uses
Used as non-nutritive sweetener; [HSDB]
NON-NUTRITIVE SWEETENER
Zugehörige Reaktionen
0
Keine Reaktionsaufzeichnungen unter den aktuellen Filterkriterien.
Notizen zur Verbindung
Wird geladen…