Methylprednisolone sodium succinate
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Grundinformationen
- CAS
2375-03-3- Standard-SMILES
C[C@H]1C[C@@H]2[C@H]([C@@H](O)C[C@@]3(C)[C@H]2CC[C@]3(O)C(=O)COC(=O)CCC(=O)[O-])[C@@]2(C)C=CC(=O)C=C12.[Na+]- InChIKey
FQISKWAFAHGMGT-SGJOWKDISA-M- Summenformel
- C26H33NaO8
- Durchschnittliche Molmasse
- 496,532 g/mol
- Monoisotopische Masse
- 496,2073123
Namen und Bezeichner
- Bevorzugter Name
- Methylprednisolone sodium succinate
- IUPAC
- Sodium 4-[(11beta,17-dihydroxy-6alpha-methyl-3,20-dioxopregna-1,4-dien-21-yl)oxy]-4-oxobutanoate
- Englischer Name
- Methylprednisolone sodium succinate
- Summenformel
- C26H33O8.Na
- Molmasse
- 497.53
Namen und Synonyme
METHYLPREDNISOLONE SODIUM SUCCINATEMethylprednisolone succinate sodium6α-methylprednisolone 21-hemisuccinate sodium salt6α-Methylprednisolone 21-hemisuccinate sodium salt1,4-PREGNADIEN-6-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-SUCCINATE, SODIUM SALT6ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 21-HEMISUCCINATE SODIUM SALT(6alpha,11beta)-21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-pregna-1,4-diene-3,20-dione monosodium saltu9088MetypredNSC 48989
Datenbank-Bezeichner
- CAS
2375-03-3- PubChem CID
- 23680530
- DTXSID
DTXSID2023303- ChEMBL
CHEMBL1201081- ChEBI
CHEBI:6890- UNII
- LEC9GKY20K
- EC Number
- 219-156-8
- Nikkaji
- J7.880H
Eigenschaften
Physikochemische Eigenschaften
- Schmelzpunkt
- 186 °C · >186°C (dec.)
- storage temp.
- Inert atmosphere,Room Temperature
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- lyophilized powder
- pka
- 4.5 · 4.5
- Farbe
- White to Off-White
- Biologische Quelle
- synthetic
- Wasserlöslichkeit
- 50 mg/mL, · water: 50mg/mL, clear, colorless to faintly yellow
- InChIKey
- FQISKWAFAHGMGT-JXAFMBTDNA-M
- SMILES
- [C@]12(C[C@@H](C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@H](C[C@]1(C)[C@@](CC[C@@]21[H])(O)C(=O)COC(=O)CCC([O-])=O)O)C)[H].[Na+] |&1:0,2,9,11,13,15,17,20,r|
- CAS Datenbank
- 2375 · 2375-03-3(CAS DataBase Reference)
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Sicherheitsdaten
- wgk
- 3
- RTECS-Nr.
- TU4154060
- risk_code
- 61-40
- Toxizität
- LD50 oral in rat: > 5gm/kg
- hazard_code
- T
- safety_code
- 53-22-36/37/39-45
- Speicherklasse
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- Hazard Classifications
- Carc. 2Repr. 1B
Chemie und Industrie
Anwendungen
BeschreibungMethylprednisolone Sodium Succinate is the sodium succinate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and anti-inflammatory effects. It is converted into active prednisolone in the body, which activates glucocorticoid receptor-mediated gene expression. This includes inducing the synthesis of the anti-inflammatory protein IkappaB-alpha and inhibiting the synthesis of nuclear factor kappa B (NF-kappaB). As a result, proinflammatory cytokine production, such as IL-1, IL-2, and IL-6, is down-regulated, and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved.
Verwenden6α-Methylprednisolone 21-Hemisuccinate is a glucocorticosteroid used in anti-inflammatory medication in the treatment of spinal cord injuries.
Anbieter92 Anbieter
北京华美互利生物化工010-56205725 · [email protected]
Hebei Chuanghai Biotechnology Co., Ltd+86-17732866630 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
武汉敬康恩生物医药科技有限公司13720134139 086-15871494362 13720134139 · [email protected]
艾吉析科技（上海）有限公司17717235263 · [email protected]
咸宁深蓝生物医药研发有限公司18171815831 · [email protected]
济南洣林医药技术有限公司0531-68659554 +8613031714605 · [email protected]
Yiwu Huixian Trading Co., Ltd+undefined86-19158725587 · [email protected]
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