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Kaliumhydrogentartrat

Potassium Bitartrate

HCID 23681127
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Grundinformationen

CAS
868-14-4
Standard-SMILES
O=C([O-])[C@H](O)[C@@H](O)C(=O)O.[K+]
InChIKey
KYKNRZGSIGMXFH-ZVGUSBNCSA-M
Summenformel
C4H5O6K
Durchschnittliche Molmasse
188,18 g/mol
Monoisotopische Masse
187,97231956

Überblick

Potassium bitartrate is an organic potassium salt of L-tartaric acid. It is a by-product of winemaking and occurs naturally in grapes, the major fruit used to produce wine. It has a role as an antimicrobial agent, a laxative, a food acidity regulator, a plant metabolite, a food anticaking agent, a food stabiliser, a food humectant and a raising agent. It contains a L-tartrate(1-).

Namen und Bezeichner

Bevorzugter Name
Potassium Bitartrate
IUPAC
potassium (2R,3R)-2,3,4-trihydroxy-4-oxobutanoate
Lokaler Name
Kaliumhydrogentartrat
Englischer Name
Potassium Bitartrate
Summenformel
C4H5KO6
Molmasse
189.19

Namen und Synonyme

Potassium bitartrateFaeculaFaeclaAcid potassium tartratePOTASSIUM ACID TARTRATEMonopotassium tartratePurified cream of tartarNPT6P8P3UUpotassium (2R,3R)-3-carboxy-2,3-dihydroxypropanoatePotassium bitartrate [USAN]Tartaric acid monopotassium saltINS NO.336(I)
Weitere Namen anzeigen
Potassium hydrogen tartrateRadix Notoginseng P.E.L(+)-Potassium hydrogen tartratefacclatartarfacculaWINELEES
INS-336(I)Monopotassium tartrate (336(i))NSC-155080E-336(I)DTXSID6042313CHEBI:32034POTASSIUM BITARTRATE [II]POTASSIUM BITARTRATE [MI]

Datenbank-Bezeichner

CAS
868-14-4
PubChem CID
23681127
DTXSID
DTXSID6042313
ChEMBL

Eigenschaften

Berechnete Struktureigenschaften

Polarare Oberfläche (TPSA)
118 Ų
H-Brücken-Donoren
3
H-Brücken-Akzeptoren
6
Frei drehbare Bindungen
3
Schwere Atome
11
Formalladung
0
Komplexität
157

Experimentelle und physikochemische Eigenschaften

Chemical ClassesMetals -> Organic Acids, Metal Salts
pH3,4 (1 % aqueous solution)
TastePLEASANT ACIDULOUS TASTE
Food AdditivesEMULSIFIER OR EMULSIFIER SALT, NUTRIENT SUPPLEMENT, PH CONTROL AGENT -> FDA Substance added to food
Density · 2 Einträge

1.984 @ 18 °C

1.954 @25 °C

Color/Form · 2 Einträge

COLORLESS CRYSTALS OR WHITE, CRYSTALLINE POWDER

SLIGHTLY OPAQUE CRYSTALS

Solubility · 2 Einträge

Partially soluble

1 G DISSOLVES IN 162 ML WATER, IN 16 ML BOILING WATER, IN 8820 ML ALCOHOL; READILY SOL IN DILUTED MINERAL ACIDS; SOL IN SOLN OF ALKALIES OR BORAX; IN WATER APPROX 0.4% @ 10 °C TO 6% @ 100 °C

Human Drugs · 2 Einträge

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Physical Description · 2 Einträge

Sicherheit und Regulatorisches

Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.

GHS-Klassifizierung

GHS Classification · 3 Einträge

This chemical does not meet GHS hazard criteria for 100% (168 of 168) of all reports.

Not Classified

Aggregated GHS information provided per 168 reports by companies from 1 notifications to the ECHA C&L Inventory.

Gefahrenhinweise

Regulatory Information · 4 Einträge

Chemical: Butanedioic acid, 2,3-dihydroxy- [R-(R*,R*)]-, monopotassium salt

Regulation (EC) No 1333/2008 (amended)

Status: Active Update: 03-02-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/11349

Butanedioic acid, 2,3-dihydroxy- (2R,3R)-, monopotassium salt: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Butanedioic acid, 2,3-dihydroxy- [R-(R*,R*)]-, monopotassium salt: Human health tier I assessment
Hazards SummaryEmergency treatment after ingestion: Laxatives-saline; [HSDB] May cause irritation; [MSDSonline]
FDA Requirements121.101; LIMITATIONS: GRAS, MISCELLANEOUS AND/OR GENERAL-PURPOSE FOOD ADDITIVE AND AS A SEQUESTRANT.
EPA Safer ChemicalChemical: Potassium tartrate
Hazard Classes and CategoriesNot Classified

Sicherheit und Schutzausrüstung

Protective Action Criteria (PAC)

Chemie und Industrie

Pharmakologische Informationen

Protein BindingNo pharmacokinetic data available.
PharmacodynamicsPotassium bitartrate potentiates bowel movements. In medical studies, it was shown to be an effective treatment for chronic constipationwhen combined with sodium bicarbonate in a polyethylene glycol-based suppository.
Mechanism of Action · 1 Eintrag

Potassium bitartrate is a carbon dioxide-releasing laxative that works by forming carbon dioxide gas, which creates a mechanical distension against the intestinal wall and induces bowel contractions. Rectal suppositories of carbon dioxide-releasing type of laxative were demonstrated to be useful and safe in the treatment of patients at risk for electrolyte disorders such as the elderly or patients with renal or cardiovascular disorders.

Biological Half-LifeNo pharmacokinetic data available.
Metabolism/MetabolitesNo pharmacokinetic data available.
Absorption, Distribution and Excretion · 4 Einträge

There is little systemic absorption expected following rectal administration of potassium bitartrate.

No pharmacokinetic data available.

No pharmacokinetic data available.

No pharmacokinetic data available.

Verwendung und Herstellung

Uses · 6 Einträge

Used as a mordant in textile dyeing; [www.ci.tucson.az.us/arthazards/medium.html] Obtained from sediments of wine manufacturing; [Merck Index] Used for coloring and galvanic tinning of metals; as reducer of chromium trioxide in mordants for wool; in dusting powders for gloves; to make hard candies; in baking powders and baking mixes; as metal processing agent (prevents oxidation); as intermediate for other potassium tartrates; to remove sulfur dioxide from waste gases (in solution); as medical cathartic; as veterinary laxative and diuretic; [HSDB]

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Auf dieser SeiteGrundinformationenÜberblickNamen und BezeichnerEigenschaftenSicherheit und RegulatorischesChemie und IndustrieZugehörige ReaktionenNotizen zur Verbindung
CHEMBL2105248
ChEBI
CHEBI:32034
UNII
NPT6P8P3UU
EC Number
212-769-1
Nikkaji
J9.201K

White crystalline or granulated powder

Colorless or white solid; [Merck Index] White powder; [MSDSonline]

Other Experimental Properties · 2 Einträge

COLORLESS, RHOMBIC CRYSTALS; SOL IN ACID, ALKALIES; INSOL IN ALC, ACETIC ACID; INDEX OF REFRACTION: 1.511, 1.550, 1.590 /D-FORM/

COLORLESS MONOCLINIC CRYSTALS; SOL IN MINERAL ACID, INSOL IN ALCOHOL; DENSITY: 1.954 /DL-FORM/

Physikochemische Eigenschaften

Schmelzpunkt
267 °C · 267°C (dec.)
Siedepunkt
318 ℃[at · 318℃[at 101 325 Pa]
Dichte
1.954 g/mL · 1.954 g/mL at 25 °C(lit.)
Dampfdruck
30.69 hPa · 30.69hPa at 25.2℃
Brechungsindex
1.511 · 1.511
Flammpunkt
210 ℃ · 210℃
storage temp.
Inert atmosphere,Room Temperature
Löslichkeit
5.7 g/l · 5.7g/l
Aggregatzustand
Crystals or Powder
Wichte
1.954 · 1.954
Farbe
Colorless opaque or white
PH
3.4 · 3.4-3.7 (H2O, 20℃)(saturated solution)
Geruch (Odor)
Odorless
Wasserlöslichkeit
Soluble in water and dilute mineral acid. Insoluble in alcohol.
Merck
14 · 14,7615
BRN
6119985 · 6119985
Stabilität
Stable. Incompatible with strong oxidizing agents.
Kosmetik-Inhaltsstoffe Funktionen
BUFFERING
InChI
1S/C4H6O6.K/c5-1(3(7)8)2(6)4(9)10;/h1-2,5-6H,(H,7,8)(H,9,10);/q;+1/p-1/t1-,2-;/m1./s1
InChIKey
KYKNRZGSIGMXFH-ZVGUSBNCSA-M
SMILES
[K+].O[C@H]([C@@H](O)C([O-])=O)C(O)=O
LogP
-5.14 · -5.14
CAS Datenbank
868 · 868-14-4(CAS DataBase Reference)
EPA chemische Informationen
Potassium bitartrate (868-14-4)
· 3 Einträge

87 [mg/m3]

960 [mg/m3]

5800 [mg/m3]

Toxikologische Informationen

Non-Human Toxicity Excerpts...TESTED BY INSTILLATION INTO ANTERIOR CHAMBER OF RABBITS & BY PLACING UNDER SUPERIOR RECTUS MUSCLE, & WAS FOUND TO PRODUCE NO SIGNIFICANT REACTION.

Regulatorische Informationen

FDA Requirements121.101; LIMITATIONS: GRAS, MISCELLANEOUS AND/OR GENERAL-PURPOSE FOOD ADDITIVE AND AS A SEQUESTRANT.

Sicherheitsdaten

wgk
1
tsca
TSCA listed
hs_code
29181300
RTECS-Nr.
WW8223000
safety_code
24/25
Speicherklasse
11 - Combustible Solids
Giftige Stoffe Daten
868-14-4(Hazardous Substances Data)

Electroplating [Category: Plate]

Textile arts [Category: Hobbies]

COLORING METALS, GALVANIC TINNING OF METALS; REDUCER OF CHROMIUM TRIOXIDE IN MORDANTS FOR WOOL

DUSTING POWDER ON GLOVES

IN MANUFACTURE OF HARD CANDIES

U.S. Exports · 2 Einträge

(1972) No Data

(1975) No Data

U.S. Imports · 2 Einträge

(1972) 1.13X10+9 GRAMS

(1975) 4.57X10+8 GRAMS

U.S. Production · 2 Einträge

(1972) GREATER THAN 4.54X10+5 GRAMS

(1975) GREATER THAN 4.54X10+5 GRAMS

Methods of Manufacturing · 4 Einträge

REACTION OF TARTARIC ACID, POTASSIUM SODIUM TARTRATE (ROCHELLE SALT), AND POTASSIUM SULFATE, FOLLOWED BY FILTRATION, PURIFICATION, PRECIPITATION, & DRYING

OBTAINED FROM SEDIMENTS IN MANUFACTURE OF WINE, KNOWN AS ARGOLS OR WINE LEES. SALT IS @ LEAST 99.5% PURE.

BY PURIFYING ARGOL OR TARTAR- SUBSTANCE DEPOSITED IN WINE CASKS DURING FERMENTATION OF GRAPE JUICE, WHICH SUBSTANCE CONSISTS OF ABOUT 80% POTASSIUM BITARTRATE.

FROM WINE LEES BY EXTRACTION WITH WATER & CRYSTALLIZATION.

Formulations/Preparations · 3 Einträge

THIS SALT IS ONE OF THE INGREDIENTS IN COMPD JALAP POWDER, FORMERLY IN THE NF.

SALT IS @ LEAST 99.5% PURE.

GRADES: TECHNICAL; NF; FCC.

Use Classification · 3 Einträge

EPA Safer Chemical Functional Use Classes -> Processing Aids and Additives

Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern

Food additives

General Manufacturing Information · 2 Einträge

Butanedioic acid, 2,3-dihydroxy- (2R,3R)-, potassium salt (1:1): ACTIVE

INCOMPATIBILITIES: BECAUSE IT CONTAINS AN ACIDIC HYDROGEN, IT CAN REACT WITH ALKALINE SUBSTANCES. ITS SLIGHT SOLUBILITY SOMETIMES CAUSES DIFFICULTY IN LIQ MIXTURES.

Anwendungen · 3 Einträge

BeschreibungL (+)-Potassium hydrogen tartrate (also known as potassium bitartrate) is the potassiumacid salt of tartaric acid (a carboxylic acid). It is the byproduct during the winemaking process. It can be used in baking or as a cleaning solution. When mixed with an acidic liquid such as lemon juice or white vinegar, it can be made of a paste-like cleaning agent for metals or some other cleaning applications. It can also be used as a pH buffer component in chemistry. It has been recently shown that it is capable of treating breast cancer. Approved by the FDA as a direct food substance, potassium bitartrate is used as an additive, stabilizer, pH control agent, antimicrobial agent, processing aid, or thickener in various food products. Potassium bitartrate has a long history of medical use as a laxative administered as a rectal suppository and is an approved third-class OTC drug in Japan. Potassium bitartrate was one of active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA on May 2020.

OccurrencePotassium bitartrate crystallizes in wine casks during the fermentation of grape juice, and can precipitate out of wine in bottles.The crystals (wine diamonds) will often form on the underside of a cork in wine-filled bottles that have been stored at temperatures below 10°C , and will seldom, if ever, dissolve naturally into the wine. These crystals also precipitate out of fresh grape juice that has been chilled or allowed to stand for some time. To prevent crystals forming in homemade grape jam or jelly, fresh grape juice should be chilled overnight to promote crystallisation. The potassium bitartrate crystals are removed by filtering through two layers of cheesecloth. The filtered juice may then be made into jam or jelly. In some cases they adhere to the side of the chilled container, making filtering unnecessary. The crude form (known as beeswing) is collected and purified to produce the white, odorless, acidic powder used for many culinary and other household purposes.

VerwendenLargely in baking powders; coloring metals, galvanic tinning of metals; reducer of CrO3 in mordants for wool.

Darstellung · 1 Eintrag

synthetischepotassium bitartrate is mainly produced from the mother liquor of Seignette's salt. These decolorized, purified, and filtered solutions are acidified to pH 3.5 with hydrochloric or sulfuric acid. Since cream of tartar is sparingly soluble, it precipitates and is recovered by centrifugation, dried, and ground before being packaged as fine powder.

Vor- und nachgelagerte Produkte

Vorgelagerte Rohstoffe

SchwefelwasserstoffDikaliumtartratKaliumhydroxidMaleinsäureanhydridDinatrium-3-hydroxynaphthalin-2,7-disulfonatWasserstoffperoxidKaliumcarbonat(+-)-WeinsureD(-)-Tartaric acidSchwefelsure, Kaliumsalz

Nachgelagerte Produkte

POTASSIUM ANTIMONY TARTRATE

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