Pyrithione Sodium

FCS -> FDA Cumulative Estimated Daily Intake (CEDI)

FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR

FCS -> FDA Inventory of Effective Food Contact Substance (FCS) Notifications

CBI

Technical product is off-white solid; Formulated as liquid soluble concentrates; [Reference #1] 3811-73-2: Hygroscopic crystalline powder with a stench; [Alfa Aesar MSDS]

Danger

H302: Harmful if swallowed [Warning Acute toxicity, oral]

P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for 0.5% (5 of 962) of reports.

Danger

H302+H312+H332 (45.9%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]

Chemical: 2-Pyridinethiol, 1-oxide, sodium salt

2-Pyridinethiol, 1-oxide, sodium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Pyridinethiol, 1-oxide, sodium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 28-04-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/20845

2(1H)-Pyridinethione, 1-hydroxy-, sodium salt: Does not have an individual approval but may be used under an appropriate group standard

Sodium pyrithione: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

A mixture of two tautomers: 1-hydroxy-2(1H)-pyridinethione, sodium salt (15922-78-8) and 2-pyridinethio-1-oxide, sodium salt (3811-73-2); Not a skin sensitizer in guinea pig or human studies; Minimum to marked hind-limb atrophy observed in 13-week gavage study of rats at highest tested dose of 8 mg/kg/day (LOEL of 2 mg/kg/day based on evidence of neurotoxicity); [Reference #1] 3811-73-2: A skin and strong eye irritant; Harmful by ingestion; [Alfa Aesar MSDS]

Acute Tox. 4 (99.4%)

Acute Tox. 4 (50%)

Acute toxicity (ingestion) - category 4

Acute toxicity (Oral) - Category 4

Acute Tox. 3

Used as biocide (controls slime forming bacteria and fungi) in aqueous functional fluids (metalworking, cutting, cooling, and lubricating), latex emulsions (adhesives, caulks, patching compounds, sealants, pastes, and grouts), aqueous fiber lubricants and inks, jet-printer inks, laundry rinse additives and detergents, carpet cleaners, analytical and diagnostic reagents; Also used as in-can preservative for water based mixtures used in making concrete (not covered in this RED); [Reference #1]

Metal Machining [Category: Heat or Machine]

Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing

2-Pyridinethiol, 1-oxide, sodium salt (1:1): ACTIVE