Natriummercaptoacetat

Cosmetic ingredients (Sodium Thioglycolate) -> CIR (Cosmetic Ingredient Review)

Reducing; Depilatory

Thioglycolic acid, sodium salt is a white powder with a slight odor. Used in cold-waving of hair and as a dipilatory.

Liquid

Hygroscopic solid with a mild characteristic odor; Discolored by air and iron; [Merck Index] White hygroscopic powder with a stench; [Acros Organics MSDS]

This chemical does not meet GHS hazard criteria for 1% (3 of 292) of reports.

Danger

H290 (12.7%): May be corrosive to metals [Warning Corrosive to Metals]

P203, P234, P260, P261, P264, P264+P265, P270, P272, P273, P280, P301+P316, P301+P317, P302+P352, P305+P351+P338, P317, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P390, P405, P406, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 292 reports by companies from 21 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

Chemical: Acetic acid, mercapto-, monosodium salt

Acetic acid, 2-mercapto-, sodium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Acetic acid, 2-mercapto-, sodium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 09-09-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14520

Sodium thioglycolate: Does not have an individual approval but may be used under an appropriate group standard

An irritant; Can be absorbed through skin; Effects to the skin at administration site, no systemic toxicity, and no evidence of developmental toxicity or teratogenicity observed in dermal study of rabbits at doses up to 65 mg/kg/day; A dermal developmental toxicity study of rats produced no NOAEL for maternal toxicity, a developmental NOAEL of 100 mg/kg/day (decreased fetal body weights per litter), and no evidence of teratogenicity; [NTP] Causes cutaneous sensitization in acute dermal studies of rabbits and rats; Causes somnolence and convulsions in oral lethal-dose studies of mice; [RTECS] A skin and strong eye irritant; Harmful by ingestion; Toxic by skin absorption; [Acros Organics MSDS] See Thioglycolic acid. See Ammonium thioglycolate.

Acute Tox. 3 (100%)

Met. Corr. 1 (12.7%)

Eye irritation - category 2A

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Based on the available data, the CIR Expert Panel concluded that ... Sodium Thioglycolate is safe for use in hair straighteners, permanent waves, tonics, dressings, and so forth, wave sets, other non-coloring hair products, and hair dyes and colors, as described in this safety assessment, at concentrations up to 15.2% (as Thioglycolic Acid). Hairdressers should avoid skin contact and minimize consumer skin exposure. Sodium Thioglycolate in depilatories is safe when formulated to be non-irritating under conditions of recommended use.

Safe for use in cosmetics, with qualifications

CIR ingredient: Sodium Thioglycolate

Used in cosmetology (cold-waving of hair and as a depilatory), bacteriology to make thioglycolate media, and as an analytical reagent; [Merck Index]

Dressing Hair [Category: Other]

All Other Basic Organic Chemical Manufacturing

Acetic acid, 2-mercapto-, sodium salt (1:1): ACTIVE