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Kupferchlorid
COPPER CHLORIDE · COPPER ATOMIC SPECTROSCOPY STANDARD · Un2802 · HAMP-OL · Kirticopper · CUPRIC CHLORIDE · Einecs 215-704-5 · Copper, diaquadichloro-
Identifikatoren & physikalische Daten
| CAS No. | 1344-67-8 |
|---|---|
| Summenformel | Cl2Cu |
| Durchschnittliche Molmasse | 134,45 g/mol |
| SMILES | [Cl][Cu][Cl] |
| InChIKey | ORTQZVOHEJQUHG-UHFFFAOYSA-L |
| PubChem CID | 24014 |
| ChEMBL | CHEMBL444436 |
| ChEBI | CHEBI:49553 |
| EC No. | 215-704-5 |
| Lokaler Name | Kupferchlorid |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 0 |
|---|---|
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 0 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 3 |
| Formalladung | 0 |
| Komplexität | 2,8 |
| Stoffklassen | Metals -> Metals, Inorganic CompoundsCorrosives |
| SpringerMaterials Properties | dielectric constant |
| Dichte | 2.54 at 68 °F (USCG, 1999) - Denser than waterwill sink3.39 @ 25 °C/4 °C3.4 @25 °C3.386 g/mL at 25 °C(lit.) |
| Color/Form | Yellow to brown, microcrystalline powderYellow-brown, monoclinic crystals |
| Löslichkeit | Green to blue powder or orthorhombic, bipyramidal crystalsdeliquescent in moist air, efflorescent in dry airwater loss occurs from 70-200 °Cmp 100 °C... freely sol in water, methanol, ethanolmoderately sol in acetone, ethyl acetateslightly sol in ether. The aq soln is acid to litmuspH of 0.2 molar soln 3.6/Dihydrate/Soluble in acetone.SOL IN HOT SULFURIC ACID.70.6 g/100 cc water @ 0 °C, 107.9 g/100 cc water @ 100 °C53 g/100 cc alcohol @ 15 °CFor more Solubility (Complete) data for COPPER(II) CHLORIDE (6 total), please visit the HSDB record page.H2O: soluble |
| Corrosivity | It is corrosive to aluminum. |
| Human Drugs | FDA approved drugs -> Active ingredient |
| Siedepunkt | 993 °C DECOMP TO CUPROUS CHLORIDE993 °C @760 [mm Hg] |
| Decomposition | ... WHEN HEATED TO DECOMP ... THEY EVOLVE TOXIC FUMES OF /HYDROGEN CHLORIDE/.993 °C DECOMP TO CUPROUS CHLORIDE |
| Schmelzpunkt | 630 °C (extrapolated)598 °C620 °C(lit.) |
| Physical Description | Copper chloride appears as a yellowish-brown powder (the anhydrous form) or a green crystalline solid (the dihydrate). Noncombustible but hydrogen chloride gas may form when heated in a fire. Corrosive to aluminum. Used to manufacture other chemicals, in dyeing, in printing, in fungicides, as a wood preservative.Cupric chloride and ammonia contains various concentrations of cupric chloride in ammonium hydroxide. This forms a copper ammonia complex. It is corrosive to skin, eyes, mucous membranes and metal. This material is used to etch copper from printed circuit boards.LiquidWet SolidDry PowderLarge CrystalsOther SolidYellow to brown deliquescent solidForms dihydrate in moist airSoluble in water[Merck Index] Yellow-brown powder[MSDSonline] |
| Stability/Shelf Life | Forms dihydrate in moist air. |
| Lagerbedingungen | 2-8°C |
| Aggregatzustand | powder |
| InChI | InChI=1S/ClH.Cu/h1H |
| InChIKey | NNIYFVYSVUWTOA-UHFFFAOYSA-N |
| SMILES | Cl.[Cu] |
| CAS Datenbank | 1344-67-8(CAS DataBase Reference) |
| EPA chemische Informationen | Copper chloride (1344-67-8) |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 0.9% (5 of 550) of reports.DangerH290 (10.4%): May be corrosive to metals [Warning Corrosive to Metals]P234, P264, P264+P265, P270, P273, P280, P301+P317, P302+P352, P305+P351+P338, P305+P354+P338, P317, P321, P330, P332+P317, P337+P317, P362+P364, P390, P391, P406, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 550 reports by companies from 33 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | Chemical: Copper chloride (CuCl2)Chemical: Copper chlorideCommission Regulation No 844/2012Copper chloride (CuCl2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Copper chloride (CuCl2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 11-11-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/14831Copper chloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right. |
| Weitere Sicherheitsinformationen | IMAP assessments - Copper chloride: Human health tier I assessmentIMAP assessments - Copper chloride (CuCl2): Human health tier I assessment |
| DOT-Kennzeichnung | CorrosiveClass 9 |
| Brandgefahren | Special Hazards of Combustion Products: Irritating hydrogen chloride gas may form in fire. (USCG, 1999)Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:· Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. |
| Brandpotenzial | It is noncombustible. |
| Gesundheitsgefahren | Inhalation causes coughing and sneezing. Ingestion causes pain and vomiting. Contact with solutions irritates eyescontact with solid causes severe eye surface injury and skin irritation. (USCG, 1999)Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:· TOXIC and/or CORROSIVEinhalation, ingestion or skin contact with material may cause severe injury or death. |
| Gefahrenübersicht | A skin and mucous membrane irritant[Merck Index] A skin and eye irritantSolid can cause severe injury to surface of eyes[CAMEO] Contact with solid causes eye injury and skin irritation[CHRIS] A corrosive substance that can cause injury to the skin, eyes, and mucous membranes[MSDSonline] See Copper. |
| DOT-Nummer und Handbuch | 2802 154 |
| Reaktive Gruppe | Salts, AcidicAmines, Phosphines, and Pyridines |
| Reactivity Profile | Solutions of COPPER CHLORIDE are acidic (they contain moderate concentrations of hydrogen ions and have pH's of less than 7.0). They react as acids to neutralize bases. These neutralizations generate heat, but far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid.CUPRIC CHLORIDE SOLUTION, [AMMONIATED] has weak oxidizing or reducing powers. Redox reactions can however still occur. The majority of compounds in this class are slightly soluble or insoluble in water. If soluble in water, then the solutions are usually neither strongly acidic nor strongly basic. These compounds are not water-reactive. |
| DOT Emergency Guidelines | /GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Health: TOXICinhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution./GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated./GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas./GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLYit is not effective in spill situations where direct contact with the substance is possible.For more DOT Emergency Guidelines (Complete) data for COPPER(II) CHLORIDE (8 total), please visit the HSDB record page. |
| DOT Hazard Classification | Copper chlorideSevere marine pollutantCupric chlorideUN2802 |
| Brandbekämpfung | Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: |
| Freisetungsmaßnahmen | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. |
| Erste Hilfe | INHALATION: move to fresh air.Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:General First Aid: |
| Expositionsschutz und Persönliche Schutzausrüstung | · Wear positive pressure self-contained breathing apparatus (SCBA).0.01 [mg/m3], respirable fraction (Cu, inorganic cmpnds)[German Research Foundation (DFG)] |
| Brandbekämpfungsverfahren | If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) |
| Lagerbedingungen | ... MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMP INTO TOXIC COMPONENTS DUE TO CONTACT WITH HEAT, MOISTURE, ACIDS, OR ACID FUMES, SHOULD BE STORED IN COOL, WELL-VENTILATED PLACE, OUT OF DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, & SHOULD BE PERIODICALLY INSPECTED AND MONITORED. INCOMPATIBLE MATERIALS SHOULD BE ISOLATED FROM EACH OTHER. /CHLORIDES/ |
| Reinigungsverfahren | Environmental consideration - land spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.Environmental consideration - water spill: Neutralize with agricultural lime (calcium oxide), crushed limestone (calcium carbonate), or sodium bicarbonate (NaHCO3). Use mechanical dredges or lifts to remove immobilized masses of pollutants & precipitates. |
| Freisetung ohne Brand | Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: |
| Entsorgungsverfahren | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
| Preventive Measures | If material not involved in fire: Keep material out of water sources & sewers. Build dikes to contain flow as necessary.Personnel protection: Keep upwind. ... Avoid breathing vapors or dusts. Wash away any material which may have contacted the body with copious amt of water or soap & water.SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place. |
| Isolation and Evacuation | Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:Immediate precautionary measure |
| Minimum Risk Level | Acute Oral: 0.01 mg/kg/day (L134) Intermediate Oral: 0.01 mg/kg/day (L134) |
| Treatment | EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration. |
| Wechselwirkungen | The effects of superoxide dismutase, catalase, copper(II) (3,5-diisopropylsalicylate)2 and other copper compounds on radiation transformation in vitro using C3H 10T1/2 cells have been studied. When present only during irradiation, cupric chloride and cuprous chloride inhibited the initiation phase of radiation transformation.The ameliorating effects of copper(+2) and sulfate(2-) ions on concurrent selenite toxicity were compared in two factorial experiments in weanling rats. 0, 500 and 1,000 mg copper (as cupric chloride)/kg diet were fed in conjuction with 0, 5, 10 and 20 mg selenium (as Na2Se)3)/kg diet. Cupric(+2) ion, but not sulfate(2-) ion, prevented mortality among selenite intoxicated rats. There were significant copper-selenium interaction effects on feed intake, daily gain, packed cell volume, serum copper and iron, sperm counts, and weights of liver, kidney and testis. Sulfate increased liver copper concentrations.Oral LD50 values (at 24 and 168 hr) for 8 metal salts were detected in female mice pretreated orally with small doses (1/10 of the challenge doses) of the same metal ions or with deionized water at 24 hr prior to the challenge doses. Pretreatment with copper(2+), had little effect on the lethality of the same ion. Pretreatment with copper(2+), mercury(2+), or zinc(2+) protected mice against the toxic action of cadmium(2+).Salts of metals which are carcinogenic, noncarcinogenic, or of unknown carcinogenicity were assayed for their abilities to modulate ultraviolet induced mutagenesis in Escherichia coli WP2. Copper chloride acted as comutagen in E coli WP2, which has wild type DNA repair capability, but was much less comutagenic in the repair deficient strain WP2S (uvra). The survival of irradiated or unirradiated cells was not affected by the compound. The comutagenic effects might occur either via metal induced decreases in the fidelity of repair replication or via metal induced depurination.For more Interactions (Complete) data for COPPER(II) CHLORIDE (6 total), please visit the HSDB record page. |
| Gesundheitliche Auswirkungen | People must absorb small amounts of copper every day because copper is essential for good health, however, high levels of copper can be harmful. Very-high doses of copper can cause damage to your liver and kidneys, and can even cause death. Copper may induce allergic responses in sensitive individuals. (L278, L279) |
| Ökotoxizitätswerte | EC50 Selenastrum capricornatum (green alga) 85 ug/l/14 days /Cell volume bioassay/EC50 Thalassiosira pseudonana (alga, saltwater) 5 ug/l/72 hr /Growth rate bioassay/EC50 Nitschia closterium (alga, saltwater) 33 ug/l/96 hr /Growth rate bioassay/EC50 Chlorella stigmatophora (alga, saltwater) 70 ug/l/21 days /Cell volume bioassay/For more Ecotoxicity Values (Complete) data for COPPER(II) CHLORIDE (7 total), please visit the HSDB record page. |
| Unerwünschte Wirkungen | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. |
| Expositionspfade | Oral (L277)inhalation (L277)dermal (L277) |
| Toxizitätsübersicht | For healthy, non-occupationally-exposed humans the major route of exposure to copper is oral. The mean daily dietary intake of copper in adults ranges between 0.9 and 2.2 mg. ... In some cases, drinking water may make a substantial additional contribution to the total daily intake of copper, particularly in households where corrosive waters have stood in copper pipes. ... All other intakes of copper (inhalation and dermal) are insignificant in comparison to the oral route. Inhalation adds 0.3-2.0 ug/day from dusts and smoke. Women using copper IUDs are exposed to only 80ug or less of copper per day from this source. The homeostasis of copper involves the dual essentiality and toxicity of the element. Its essentiality arises from its specific incorporation into a large number of proteins for catalytic and structural purposes. The cellular pathways of uptake, incorporation into protein and export of copper are conserved in mammals and modulated by the metal itself. Copper is mainly absorbed through the gastrointestinal tract. From 20 to 60% of the dietary copper is absorbed, with the rest being excreted through the feces. Once the metal passes through the basolateral membrane it is transported to the liver bound to serum albumin. The liver is the critical organ for copper homeostatis. The copper is partitioned for excretion through the bile or incorporation into intra- and extracellular proteins. The primary route of excretion is through the bile. The transport of copper to the peripheral tissues is accomplished through the plasma attached to serum albumin, ceruloplasmin or low-molecular weight complexes. ... The biochemical toxicity of copper, when it exceeds homeostatic control, is derived from its effects on the structure and function of biomolecules, such as DNA, membranes and proteins directly or through oxygen-radical mechanisms. The toxicity of a single oral dose of copper varies widely between species. ... The major soluble salts (copper(II) sulfate, copper(II) chloride) are generally more toxic than the less soluble salts (copper(II) hydroxide, copper (II) oxide). Death is preceded by gastric hemorrhage, tachycardia, hypotension, hemolytic crisis, convulsions and paralysis. ... Long-term exposure in rats and mice showed no overt signs of toxicity other than a dose-related reduction in growth after ingestion ... The effects included inflammation of the liver and degeneration of kidney tubule epithelium. ... Some testicular degeneration and reduced neonatal body and organ weights were seen in rats ... and fetotoxic effects and malformations were seen at high dose levels. ... Neurochemical changes have been reported after oral administration ... A limited number of immunotoxicity studies showed humoral and cell-mediated immune function impairment in mice after oral intakes in drinking-water ... Copper is an essential element and adverse health effects /in humans/ are related to deficiency as well as excess. Copper deficiency is associated with anemia, neutropenia and bone abnormalities but clinically evident deficiency is relatively infrequent in humans. .. Except for occasional acute incidents of copper poisoning, few effects are noted in normal /human/ populations. Effects of single exposure following suicidal or accidental oral exposure have been reported as metallic taste, epigastric pain, headache, nausea, dizziness, vomiting and diarrhea, tachycardia, respiratory difficulty, hemolytic anemia, hematuria, massive gastrointestinal bleeding, liver and kidney failure, and death. Gastrointestinal effects have also resulted from single and repeated ingestion of drinking-water containing high copper concentrations, and liver failure has been reported following chronic ingestion of copper. Dermal exposure has not been associated with systemic toxicity but copper may induce allergic responses in sensitive individuals. Metal fume fever from inhalation of high concentrations in the air in occupational settings have been reported ... A number of groups are described where apparent disorders in copper homeostasis result in greater sensitivity to copper deficit or excess than the general population. Some disorders have a well-defined genetic basis. These include Menkes disease, a generally fatal manifestation of copper deficiencyWilson disease (hepatolenticular degeneration), a condition leading to progressive accumulation of copperand hereditary aceruloplasminemia, with clinical symptoms of copper overload. Indian childhood cirrhosis and idiopathic copper toxicosis are conditions related to excess copper which may be associated with genetically based copper sensitivity ... These are fatal conditions in early childhood where copper accumulates in the liver. ... Other groups potentially sensitive to copper excess are hemodialysis patients and subjects with chronic liver disease. Groups at risk of copper deficiency include infants (particularly low birth weight/preterm babies, children recovering from malnutrition, and babies fed exclusively with cow's milk), people with maladsorption syndrome (e.g., celiac disease, sprue, cystic fibrosis), and patients on total parenteral nutrition. Copper deficiency has been implicated in the pathogenesis of cardiovascular disease. The adverse effects of copper must be balanced against its essentiality. Copper is an essential element for all biota ... At least 12 major proteins require copper as an integral part of their structure. It is essential for the utilization of iron in the formation of hemoglobin, and most crustaceans and molluscs possess the copper-containing hemocyanin as their main oxygen-carrying blood protein. ... A critical factor in assessing the hazard of copper is its bioavailablity. Adsorption of copper to particles and complexation by organic matter can greatly limit the degree to which copper will be accumulated ... At many sites, physiochemical factors limiting bioavailability will warrant higher copper limits. ...Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes become saturated and copper accumulates in the nucleus, causing nuclear damage. This damage is possibly a result of oxidative damage, including lipid peroxidation. Copper inhibits the sulfhydryl group enzymes such as glucose-6-phosphate 1-dehydrogenase, glutathione reductase, and paraoxonases, which protect the cell from free oxygen radicals. It also influences gene expression and is a co-factor for oxidative enzymes such as cytochrome C oxidase and lysyl oxidase. In addition, the oxidative stress induced by copper is thought to activate acid sphingomyelinase, which lead to the production of ceramide, an apoptotic signal, as well as cause hemolytic anemia. Copper-induced emesis results from stimulation of the vagus nerve. (L277, T49, A174, L280) |
| Signs and Symptoms | Breathing high levels of copper can cause irritation of the nose and throat. Ingesting high levels of copper can cause nausea, vomiting, diarrhea, headache, dizziness, and respiratory difficulty. (L278, L279) |
| Human Toxicity Excerpts | IN GENERAL SOL IONIZED SALTS OF COPPER ARE MUCH MORE TOXIC THAN INSOL OR SLIGHTLY DISSOCIATED CMPD. PROBABLY THE MOST POISONOUS SALTS ARE CHLORIDE & SUBACETATE. |
| Carcinogen Classification | No indication of carcinogenicity to humans (not listed by IARC). |
| Drug Induced Liver Injury | Drug Induced Liver Injury Rank (DILIrank 2.0)Cupric chloridevNo-DILI-concernNo matchDOI:10.1016/j.drudis.2016.02.015 |
| Non-Human Toxicity Excerpts | COPPER CHLORIDE APPLIED IN 0.08 TO 0.16 MOLAR SOLN TO CORNEAS OF RABBITS AFTER REMOVAL OF EPITHELIUM, OR INJECTED INTO STROMA, CAUSES SEVERE REACTION WITH PERMANENT OPACIFICATION.... 25 MG OF COPPER CHLORIDE INJECTED SC IN 1% SOLN IN RABBITS CAUSED LOCAL NECROSIS & LOSS IN WT. ...The freshwater teleost Tilapia mossambica was subjected to lethal (6.0 mg/l= LC50/48 hr) and sublethal (1.5 mg/l) copper treatment for 1, 7, and 14 days. The whole animal oxygen consumption and the activity levels of succinate dehydrogenase and lactate dehydrogenase in liver and muscle were studied. The decrease in oxygen consumption and succinate dehydrogenase activity and significant increase in lactate dehydrogenase activity suggest that the stressed fish is meeting its energy requirement through anaerobic oxidation and these enzymes can be used as indicators in monitoring metal induced toxicity in fish.The role of lysosomes in the pathogenesis of copper induced hepatotoxicity was studied in mice. Two strains of female C57B1-mice (conventional and beige) were injected intraperitoneally with 0 or 8 milligrams per kilogram aqueous copper (II) chloride daily for up to 4 weeks. Macroscopically, the livers of mice treated for 1 week were similar to those of the controls. After 2 weeks, livers of treated animals were diffusely tan to red and the edges of the individual lobes were blunted. At 4 weeks, the livers were gray to tan, and their lobes were marked rounded. Hepatic lesions consisting of karyomegaly, accumulation of lipofuscin within hepatocytes, and Kupffer cells, acute necrosis of random hepatocytes, and aggregation of leukocytes within the sinusoids developed in both strainshowever, they developed more quickly and were more severe in beige mice. In both strains, the onset of the hepatic lesions closely paralleled the appearance and distribution of copper within the leukocytes. Beige mice are more susceptible to copper mediated hepatotoxicity, suggesting that normal lysosomes have protective effects for hepatocytes by sequestering copper from other cytoplasmic components.For more Non-Human Toxicity Excerpts (Complete) data for COPPER(II) CHLORIDE (13 total), please visit the HSDB record page. |
| CERCLA-Meldepflichtmengen | Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 10 lb or 4.54 kg. The toll free number of the NRC is (800) 424-8802In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). |
| Clean Water Act Anforderungen | Cupric chloride is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance.Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Copper and cmpd/ |
| Landesrichtlinien für Trinkwasser | (AZ) ARIZONA 1300 ug/l /Copper/ |
| Federal Drinking Water Standards | EPA 1300 ug/l (Action Level) /Copper/ |
| Bundesrichtlinien für Trinkwasser | EPA 1000 ug/l /Copper/ |
| F | 3 |
| Wassergefährdungsklasse (WGK) | 2 |
| TSCA-Inventar-Status | TSCA listed |
| UN-Transportnummer | UN 3264 8/PG 3 |
| RTECS-Nr. | GL7000000 |
| R-Sätze (R) | 52/53 |
| Gefahrensymbole | N |
| Sicherheitshinweise (S) | 61 |
Anwendungen & Verwendung
Verwenden
Isomerization and cracking catalyst, mordant in dyeing and printing fabrics, sympathetic ink, disinfectant, pyrotechnics, wood preservation, fungicides, metallurgy, preservation of pulpwood, deodorizing and desulfurizing petroleum distillates, photography, water purification, feed additive, electroplating baths, pigment for glass and ceramics, acrylonitrile manufacturing.