| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 85.8% (994 of 1158) of all reports.WarningH319 (12.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)Aggregated GHS information provided per 1158 reports by companies from 16 notifications to the ECHA C&L Inventory. |
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| Regulatorische Informationen | Chemical: Phosphoric acid, ammonium salt (1:1)Phosphoric acid, ammonium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Phosphoric acid, ammonium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 11-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15548Monoammonium phosphate: Does not have an individual approval but may be used under an appropriate group standard |
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| Weitere Sicherheitsinformationen | IMAP assessments - Phosphoric acid, monoammonium salt: Environment tier I assessment |
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| Gefahrenübersicht | A skin and eye irritant that may cause respiratory tract irritationthe diammonium form of ammonium phosphate may release enough ammonia in an enclosed space to cause pulmonary edema[CAMEO] |
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| FDA-Anforderungen | Substance added directly to human food affirmed as generally recognized as safe (GRAS).Ammonium phosphate (mono-, and dibasic) used as a general purpose food additive in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice. |
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| Special Reports | WHODiseases Caused by Phosphorus and Its Toxic CompoundsEarly Detection of Occupational Diseases pg 53-62 (1986). Review of diseases and health related effects resulting from exposure to phosphorus or phosphorus cmpd. |
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| FIFRA-Anforderungen | Residues of monoammonium phosphate are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. Use: Postharvest fumigation in formulation with aluminum phosphide. Limit: No more than 3.75% by weight in formulation. |
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| Toxic Combustion Products | Toxic and irritating fumes of ammonia and oxides of nitrogen may form in fires. |
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| Hazard Classes and Categories | Eye Irrit. 2 (12.1%) |
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| Hazardous Reactivities and Incompatibilities | A self-propagating reaction can occur when either sodium bicarbonate or potassium bicarbonate-based dry chemical extinguishing agent is mixed with monoammonium phosphate dry chemical extinguishing agent. Moisture will accelerate the reaction. Products are water, ammonia, carbon dioxide and various solid substances. In a fire extinguisher the pressure developed will blow out the valve.An explosive reaction occurred when monoammonium phosphate was used to extinguish a sodium fire. No reactions were experienced when sodium bicarbonate or potassium bicarbonate was used in a sodium fire. |
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| Entsorgungsverfahren | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal and plant lifeand conformance with environmental and public health regulations. |
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| Allowable Tolerances | Residues of monoammonium phosphate are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. Use: Postharvest fumigation in formulation with aluminum phosphide. Limit: No more than 3.75% by weight in formulation. |
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| Protective Action Criteria (PAC) | 17 [mg/m3]190 [mg/m3]1100 [mg/m3] |
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| Human Toxicity Excerpts | /SIGNS AND SYMPTOMS/ Acute ... eye contact with concentrated alkali causes conjunctival edema and corneal destruction. Alkalies penetrate skin slowly. Extent of damage therefore depends on duration of contact. Chronic poisoning (from skin contact). Chronic dermatitis may follow repeated contact ... /Alkalies and Phosphates//OTHER TOXICITY INFORMATION/ ... With large doses of ... ammonium /salts/, there arises the possibility of sufficient absorption to produce diuresis and systemic ammonia poisoning, particularly if material is administered parenterally. /Ammonium Salts/ |
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| Non-Human Toxicity Excerpts | /LABORATORY ANIMALS: Acute Exposure/... It has been shown that solutions containing 0.1 molar ... ammonium phosphate ... at pH 7-7.5 made up to 0.46 osmolar (1.5 times isotonic concentration) by addition of sodium chloride or sucrose and dripped continuously on eyes of rabbits caused edema of epithelium of the cornea within 3-3.5 hr. /Ammonium Phosphate/ |
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| Probable Routes of Human Exposure | According to the 2006 TSCA Inventory Update Reporting data, the number of persons reasonably likely to be exposed in the industrial manufacturing, processing, and use of ammonium dihydrogen phosphate is 1000 or greaterthe data may be greatly underestimated(1). |
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| Antidote and Emergency Treatment | /SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Ammonia and related compounds//SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for signs of pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mg/kg up to 200 ml of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool ... . Do not attempt to neutralize. /Ammonia and related compounds//SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Ammonium and related compounds//SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Phosphorus and related compounds/For more Antidote and Emergency Treatment (Complete) data for AMMONIUM DIHYDROGEN PHOSPHATE (6 total), please visit the HSDB record page. |
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| RAIS Toxicity Values | 48.6PPRTV Archive0.09PPRTV Current |
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| Acceptable Daily Intakes | FAO/WHO Expert Committee on Food Additives ... recommended ... /levels/ for total dietary phosphorus ... unconditional acceptance level /of less than 30 mg/kg body wt/ is considered safe in any type of diet ... conditional acceptance level /of 30-70 mg/kg body wt/ is acceptable only when dietary calcium level is high. /Phosphates/ |
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| Non-Human Toxicity Values | LD50 Rabbit dermal >7940 mg/kg bwLD50 Rat oral 5750 mg/kg bw |
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| EPA Provisional Peer-Reviewed Toxicity Values | Monoammonium phosphate9 x 10^-2 mg/kg-dayPDF DocumentInadequate information to assess carcinogenic potential2021 |
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| TSCA-Inventar-Status | TSCA listed |
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