| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 6.2% (95 of 1523) of reports.DangerH302 (51.1%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 1523 reports by companies from 28 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
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| Regulatorische Informationen | Chemical: Diphosphoric acid, tetrasodium saltDiphosphoric acid, sodium salt (1:4) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Diphosphoric acid, sodium salt (1:4) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 03-12-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/14859Tetrasodium pyrophosphate: Does not have an individual approval but may be used under an appropriate group standard |
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| Weitere Sicherheitsinformationen | IMAP assessments - Diphosphoric acid, tetrasodium salt: Human health tier I assessment |
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| Brandgefahren | Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
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| Gesundheitsgefahren | Excerpt from NIOSH Pocket Guide for Tetrasodium pyrophosphate: |
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| Gefahrenübersicht | Documentation and TLV withdrawn in 2006 because of insufficient data[ACGIH] A skin, eye, and respiratory tract irritant[ICSC] |
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| FDA-Anforderungen | Tetrasodium pyrophosphate used as a sequestrant in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice.Tetrasodium pyrophosphate used as a sequestrant in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice. |
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| Reaktive Gruppe | Anhydrides |
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| EPA Safer Chemical | Chemical: Sodium pyrophosphate |
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| FIFRA-Anforderungen | As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Tetrasodium pyrophosphate is found on List D. Case No: 4053Pesticide type: fungicide, herbicide, antimicrobialCase Status: None of the active ingredients in the case are being supported for reregistration by their registrants. All are unsupported, or some are unsupported and some are cancelled. Cases described as "unsupported" generally are being processed for cancellation.Active ingredient (AI): Tetrasodium pyrophosphateAI Status: The active ingredient is no longer contained in any registered products ... "cancelled."Residues of tetrasodium pyrophosphate are exempted from the requirement of a tolerance when used as a anticaking agent or conditioning agent in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. |
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| Reactivity Profile | TETRASODIUM PYROPHOSPHATE is basic. Reacts exothermically with acids. Incompatible with strong oxidizing agents. Decomposes in ethyl alcohol. |
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| Chemical Dangers | Decomposes on burning. The solution in water is a weak base. |
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| Flammable Limits | Noncombustible Solid |
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| Brandbekämpfung | In case of fire in the surroundings, use appropriate extinguishing media. |
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| Erste-Hilfe-Maßnahmen | Fresh air, rest. Refer for medical attention.Remove contaminated clothes. Rinse and then wash skin with water and soap.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Refer for medical attention . |
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| Erste Hilfe | Excerpt from NIOSH Pocket Guide for Tetrasodium pyrophosphate:(General first aid procedures) |
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| Entsorgungsverfahren | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
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| Verschüttetes entsorgen | Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. |
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| Preventive Measures | The worker should immediately wash the skin when it becomes contaminated.Work clothing that becomes wet or significantly contaminated should be removed and replaced.Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises. |
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| Eye Prevention | Wear safety spectacles. |
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| Inhalation Risk | Evaporation at 20 °C is negligiblea harmful concentration of airborne particles can, however, be reached quickly , especially if powdered. |
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| Skin Prevention | Protective gloves. |
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| Exposure Prevention | PREVENT DISPERSION OF DUST! |
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| Allowable Tolerances | Residues of tetrasodium pyrophosphate are exempted from the requirement of a tolerance when used as a anticaking agent or conditioning agent in accordance with good agricultural practices as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. |
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| Ingestion Prevention | Do not eat, drink, or smoke during work. |
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| Wechselwirkungen | ... Sodium pyrophosphate inhibits both the deposition of calcium salts and the formation of a calcifiable matrix in the aorta of rats treated with large doses of vitamin D. |
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| Zielorgane | Eyes, skin, respiratory system |
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| Expositionspfade | The substance can be absorbed into the body by inhalation of dust and by ingestion.inhalation, ingestion, skin and/or eye contact |
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| Toxizitätsübersicht | The CIR Expert Panel concluded that the following 31 ingredients are safe in the present practices of use and concentration in cosmetics as described in this safety assessment, when formulated to be non-irritating...Tetrasodium Pyrophosphate...Safe for use in cosmetics, with qualificationsIDENTIFICATION AND USE: This chemical is a colorless, transparent crystals or white powder or granules. It is odorlessslightly soluble in waterinsoluble in alcohol and ammonia. This chemical is used as a cleaning compoundoil well drillingwater treatment, cheese emulsificationas a general sequestering agent, to remove rust stainsas am ingredient of one fluid ink eradicators, in electrodeposition of metals. It is used in textile dyeingscouring of woolbufferfood additivedetergent builderwater softener and dispersant. HUMAN EXPOSURE AND TOXICITY: Alkaline and irritating. Nausea, vomiting and diarrhea are probable after ingestion. Medical reports of acute exposures show mild to moderate dermal and ocular responses. ANIMAL STUDIES: Tetrasodium pyrophosphate when added to the diets of rats in high concentrations it caused kidney damage. This chemical caused teratogenic effects in chicken embryos. Acute studies show that direct contact causes severe irritation and corneal injury in the rabbit eye and that it may be irritating to skin. This chemical can be considered moderately toxic on ingestion, inducing metabolic acidosis, and hypocalcemia. |
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| Signs and Symptoms | Cough. Sore throat.Redness.Redness. Pain.Nausea. Vomiting. Diarrhoea.irritation eyes, skin, nose, throatdermatitis |
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| Human Toxicity Excerpts | ALKALINE AND IRRITATING. NAUSEA, VOMITING AND DIARRHEA ARE PROBABLE AFTER INGESTION.Medical reports of acute exposures ... show mild to moderate dermal and ocular responses. |
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| Non-Human Toxicity Excerpts | WHEN TSPP WAS ADDED TO THE DIET OF RATS FOR A PERIOD OF 6 MONTHS, MAXIMUM LEVEL TOLERATED EXCEEDED 1.8%, BUT WAS LESS THAN 3.0%. EXCESS PHOSPHATE CAUSED KIDNEY DAMAGE. /FROM TABLE/WHEN TSPP WAS ADDED TO THE DIET OF RATS FOR A PERIOD OF 16 WK, MAXIMUM LEVEL TOLERATED WAS LESS THAN 1%. EXCESS PHOSPHATE CAUSED KIDNEY DAMAGE. /FROM TABLE/SIGNIFICANT TOXICITY WAS PRODUCED IN DEVELOPING CHICKEN EMBRYOS UNDER ALL TEST CONDITIONSYOLK TREATMENT (0.125-5 MG/EGG) @ 0 HR RESULTED IN ONLY 1 BIRD WITH SERIOUS ANOMALY (ECTOPIA CARDIS). TREATMENTS RESULTED IN MANY BIRDS WITH SEVERE & USUALLY MULTIPLE TERATA.Acute studies show that direct contact causes severe irritation and corneal injury in the rabbit eye and that it may be irritating to skin.For more Non-Human Toxicity Excerpts (Complete) data for TETRASODIUM PYROPHOSPHATE (6 total), please visit the HSDB record page. |
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| RAIS Toxicity Values | 1PPRTV Current4 |
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| Hazard Quotient Level 0.1 or Cancer Risk Level 1E-06 | 7.80e+041.20e+062.00e+041.5E+01(G)1.00e+00Volatile |
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| Hazard Quotient Level 3 or Cancer Risk Level 1E-04 | 2.30e+053.50e+066.00e+041.5E+01 (G)1.00e+00Volatile |
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| Alarmwort | Warnung |
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| Gefahrenhinweise | Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code H302 |
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