Bromazepam

KL-001 · laxvii · Normoc · La xvii · Lekotam · Lexomil · Lexotan · Lectopam

Identifikatoren & physikalische Daten

CAS No.	1812-30-2
Summenformel	C14H10BrN3O
Durchschnittliche Molmasse	316,15 g/mol
Monoisotopische Masse	315,00072 g/mol
SMILES	O=C1CN=C(c2ccccn2)c2cc(Br)ccc2N1
InChIKey	VMIYHDSEFNYJSL-UHFFFAOYSA-N
PubChem CID	2441
ChEMBL	CHEMBL277062
ChEBI	CHEBI:31302
EC No.	217-322-4
DTXSID	DTXSID40171081
Lokaler Name	Bromazepam

Chemische & physikalische Eigenschaften

XLogP	1,7
Polarare Oberfläche (TPSA)	54,4
H-Brücken-Donoren	1
H-Brücken-Akzeptoren	3
Frei drehbare Bindungen	1
Schwere Atome	19
Formalladung	0
Komplexität	385
LogP (Verteilungskoeffizient)	2.05
Löslichkeit	3.99e-02 g/LPractically insoluble in water, slightly soluble or sparingly soluble in ethanol (96 per cent) and in methylene chloride.
Physical Description	Solid
Kovats Retention Index	259126262601261326332637.7
Collision Cross Section	159.8 Å² [M+H]+ [CCS Type: TWMethod: Major Mix IMS/Tof Calibration Kit (Waters)]
Schmelzpunkt	237-238.5oC (dec.)
Siedepunkt	490.7±45.0 °C(Predicted)
Dichte	1.5573 (rough estimate)
Brechungsindex	1.6520 (estimate)
Flammpunkt	11 °C
Lagerbedingungen	2-8°C
pKa (Säurekonstante)	pKa 2.5(spectro, polarographic) (Uncertain)5.2(spectro, polarographic) (Uncertain)11.8(spectro, polarographic) (Uncertain)
Aggregatzustand	A crystalline solid
CAS Datenbank	1812-30-2(CAS DataBase Reference)
NIST chemische Informationen	Bromazepam(1812-30-2)

Sicherheit & Vorschriften

GHS-Einstufung	WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]H315 (87.8%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (87.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H335 (87.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 49 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Regulatorische Informationen	DEA schedule IV controlled substance2H-1,4-Benzodiazepin-2-one, 7-bromo-1,3-dihydro-5-(2-pyridinyl)-: Does not have an individual approval but may be used under an appropriate group standard
Weitere Sicherheitsinformationen	IMAP assessments - 2H-1,4-Benzodiazepin-2-one, 7-bromo-1,3-dihydro-5-(2-pyridinyl)-: Environment tier I assessmentIMAP assessments - 2H-1,4-Benzodiazepin-2-one, 7-bromo-1,3-dihydro-5-(2-pyridinyl)-: Human health tier I assessment
Hazard Classes and Categories	Acute Tox. 4 (100%)Skin Irrit. 2 (87.8%)Eye Irrit. 2 (87.8%)STOT SE 3 (87.8%)
Treatment	General supportive measures should be employed, along with intravenous fluids, and an adequate airway maintained. Hypotension may be combated by the use of norepinephrine or metaraminol. Dialysis is of limited value. Flumazenil (Anexate) is a competitive benzodiazepine receptor antagonist that can be used as an antidote for benzodiazepine overdose. In particular, flumazenil is very effective at reversing the CNS depression associated with benzodiazepines but is less effective at reversing respiratory depression. Its use, however, is controversial as it has numerous contraindications. It is contraindicated in patients who are on long-term benzodiazepines, those who have ingested a substance that lowers the seizure threshold, or in patients who have tachycardia or a history of seizures. As a general rule, medical observation and supportive care are the mainstay of treatment of benzodiazepine overdose. Although benzodiazepines are absorbed by activated charcoal, gastric decontamination with activated charcoal is not beneficial in pure benzodiazepine overdose as the risk of adverse effects often outweigh any potential benefit from the procedure. It is recommended only if benzodiazepines have been taken in combination with other drugs that may benefit from decontamination. Gastric lavage (stomach pumping) or whole bowel irrigation are also not recommended.

Anwendungen & Verwendung

Beschreibung

Bromazepam is a psychoactive benzodiazepine derivative and prescription drug that is commonly abused and often used in ‘drug-facilitated crimes’. This product is intended for forensic and research applications.

Verwenden

Controlled substance (depressant). Anxiolytic.