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Vanadium trichloride oxide

HCID 24410
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Grundinformationen

CAS
7727-18-6
Standard-SMILES
Cl.Cl.Cl.[O]=[V]
InChIKey
JNKMSLLEOBTKQY-UHFFFAOYSA-N
Summenformel
Cl3H3OV
Durchschnittliche Molmasse
176,32 g/mol

Überblick

Vanadium oxytrichloride is a vanadium coordination entity. It has a role as a NMR chemical shift reference compound, a catalyst and an oxidising agent.

Namen und Bezeichner

Bevorzugter Name
Vanadium trichloride oxide
IUPAC
oxovanadium;trihydrochloride

Namen und Synonyme

Vanadium trichloride oxideRefChem:901659VANADIUM OXYTRICHLORIDE7727-18-6Vanadyl trichlorideVanadium(V) oxytrichlorideTrichlorooxovanadiumTrichlorooxovanadium oxideVanadium, trichlorooxo-, (T-4)-Vanadium oxide trichlorideTrichlorooxo vanadiumVanadium monoxide trichloride
Weitere Namen anzeigen
Vanadium trichloride monoxideVanadium trichloride monooxideVanadium(V) trichloride oxideVanadium, trichlorooxo-Vanadyl chloride (VOCl3)VOCl3HSDB 1023Vanadium chloride oxide (VOCl3)

Datenbank-Bezeichner

CAS
7727-18-6
PubChem CID
24410
DTXSID
DTXSID7064784
ChEBI
CHEBI:231500
EC Number
231-780-2

Eigenschaften

Berechnete StruktureigenschaftenWird ergänzt

Polarare Oberfläche (TPSA)
17,1 Ų
H-Brücken-Donoren
3
H-Brücken-Akzeptoren
1
Frei drehbare Bindungen
0
Schwere Atome
5
Formalladung
0
Komplexität
6,9

Sicherheit und Regulatorisches

Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.

GHS-Klassifizierung

GHS Classification · 6 Einträge

This chemical does not meet GHS hazard criteria for 4.7% (5 of 107) of reports.

Danger

H301 (92.5%): Toxic if swallowed [Danger Acute toxicity, oral]

P260, P262, P264, P264+P265, P270, P273, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P361+P364, P363, P391, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 107 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

Gefahrenhinweise

Regulatory InformationStatus: Active Update: 21-01-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/12388
Hazard Classes and Categories · 3 Einträge

Acute Tox. 3 (92.5%)

Acute toxicity (Oral) - Category 2

Acute toxicity (Oral) - Category 3

Sicherheit und Schutzausrüstung

Minimum Risk LevelAcute Inhalation: 0.0002 mg/m3 (L134) Intermediate Oral: 0.003 mg/kg/day (L134)

Toxikologische Informationen

Treatment · 1 Eintrag

EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.

Chemie und Industrie

Pharmakologische Informationen

Metabolism/Metabolites · 1 Eintrag

Vanadium is absorbed mainly via inhalation, though small amounts can be absorbed through the skin and gastrointestional tract. It is rapidly distributed in the plasma, mainly to the kidney, liver, lungs, heart, bone, where it tends to accumulate. With the help of cytochrome P-450 enzymes, it can interconvert between its two oxidation states, vanadyl (V+4) and vanadate (V+5). Both states of vanadium can reversibly bind to transferrin protein in the blood and then be taken up into erythrocytes. Vanadium is excreted mainly in the urine. (L837)

Verwendung und Herstellung

UsesVanadium oxytrichloride is used as a reagent in organic synthesis. (L841)

Zugehörige Reaktionen

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Reaktionsaufzeichnung erstellen
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HRID 26178als Eduktuspto-grants-1979_04
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Reaktionsgleichung von HRID 597602
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Reaktionsgleichung von HRID 1264191
HRID 1264191als Katalysatoruspto-grants-2003_04
Reaktionsgleichung von HRID 1462975
HRID 1462975als Katalysatoruspto-grants-1984_07
Reaktionsgleichung von HRID 1462976
HRID 1462976als Katalysatoruspto-grants-1984_07
Reaktionsgleichung von HRID 1462978
HRID 1462978als Katalysatoruspto-grants-1984_07
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Health EffectsBreathing high levels of vanadium affects the lungs, throat, and eyes. Ingestion of vanadium may cause kidney and liver damage, birth defects, or death. (L837)
Exposure RoutesOral (L837) ; inhalation (L837) ; dermal (L837)
Toxicity Summary · 1 Eintrag

Vanadium damages alveolar macrophages by decreasing the macrophage membrane integrity, thus impairing the cells' phagocytotic ability and viability. The pentavalent form of vanadium, vanadate, is a potent inhibitor of the Ca+-ATPase and Na+,K+-ATPase of plasma membranes, which decreases intracellular ATP concentration. Vanadium is also believed to induce the production of reactive oxygen species. This may damage DNA and also cause oxidative stress, which can damage the reproductive system. Vanadium also inhibits protein tyrosine phosphatases, producing insulin-like effects. (L837, A247, A248, A249, A250, A251)

Signs and SymptomsInhalation of vanadium causes lung irritation, coughing, wheezing, chest pain, runny nose, and a sore throat. (L837)
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Toxicity DataLD50: 140 mg/kg (Oral, Rat) (T14)