Grundinformationen
- Standard-SMILES
O=S(=O)([O-])[O-].[Ba+2]- InChIKey
TZCXTZWJZNENPQ-UHFFFAOYSA-L- Summenformel
- BaSO4
- Durchschnittliche Molmasse
- 233,39 g/mol
- Monoisotopische Masse
- 233,85697668
Überblick
Barium sulfate appears as white or yellowish odorless powder or small crystals. Mp: 1580 °C (with decomposition). Density: 4.25 -4.5 g cm-3. Insoluble in water, dilute acids, alcohol. Soluble in hot concentrated sulfuric acid. Used as a weighting mud in oil-drilling, in paints, paper coatings, linoleum, textiles, rubber. Administered internally ("barium cocktail") as a radio-opaque diagnostic aid.
Namen und Bezeichner
- Bevorzugter Name
- Barium Sulfate
- IUPAC
- barium(2+) sulfate
Namen und Synonyme
Weitere Namen anzeigen
Datenbank-Bezeichner
- CAS
13462-86-7、7727-43-7- PubChem CID
- 24414
- DTXSID
DTXSID0050471- ChEMBL
CHEMBL2105897- ChEBI
CHEBI:133326- UNII
- 25BB7EKE2E
- EC Number
- 231-784-4、236-664-5、643-039-4
- Nikkaji
- J2.268C
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 88,6 Ų
- H-Brücken-Donoren
- 0
- H-Brücken-Akzeptoren
- 4
- Frei drehbare Bindungen
- 0
- Schwere Atome
- 6
- Formalladung
- 0
- Komplexität
- 62,2
Experimentelle und physikochemische Eigenschaften
Polymers
Plastics -> Pigments agents
Plastics -> Polyolefin-I; PUR; Polyolefin-II; PVC (soft); ABS; PVC (rigid); PET; PMMA; PA; PC; (E)PS
Cosmetics
Cosmetic ingredients (Barium Sulfate) -> CIR (Cosmetic Ingredient Review)
Cosmetic colorant; Opacifying
Density
4.25 to 4.5 (NIOSH, 2024)
4.49 g/cu cm
4.5 g/cm³
4.25-4.5
4.49 @25 °C
4.25-4.5
Color/Form
Fine, heavy powder or polymorphous crystals
White, orthorhombic crystals
White or yellowish powder
Opaque powder
Solubility
0.0002 % at 64 °F (NIOSH, 2024)
Very slightly soluble in cold water
SOLUBILITY IN WATER INCREASES CONSIDERABLY IN PRESENCE OF CHLORIDE & OTHER ANIONS
0.00031 g/100 g water at 20 °C; insol in ethanol
Soluble in hot concentrated sulfuric acid; practically insoluble in dilute acids and alcohol
Practically insoluble in organic solvents; very slightly soluble in alkalis and in solution of many salts
Human Drugs
Breast Feeding; Lactation; Contrast Media; Barium Compounds;
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Diagnostic agents > Radiocontrast media
Boiling Point
2912 °F at 760 mmHg (Decomposes) (NIOSH, 2024)
decomposes
2912 °F (decomposes)
2912 °F (Decomposes)
Decomposition
When heated to decomposition it emits toxic fumes of /sulfur oxides/.
Decomposes above 1600 °C
1600 °C
Sicherheit und Regulatorisches
GHS-Klassifizierung
GHS Classification
This chemical does not meet GHS hazard criteria for 91% (1648 of 1811) of all reports.
Not Classified
Aggregated GHS information provided per 1811 reports by companies from 18 notifications to the ECHA C&L Inventory.
This chemical does not meet GHS hazard criteria for 83.4% (276 of 331) of all reports.
Warning
H302 (16.6%): Harmful if swallowed [Warning Acute toxicity, oral]
Gefahrenhinweise
Regulatory Information
Chemical: Sulfuric acid, barium salt (1:1)
Chemical: Barite (Ba(SO4))
Sulfuric acid, barium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Sulfuric acid, barium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Barite (Ba(SO4)) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Barite (Ba(SO4)) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 01-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/15235
Barytes: Does not have an individual approval but may be used under an appropriate group standard
Other Safety Information
IMAP assessments - Barite (Ba(SO4)): Human health tier I assessment
IMAP assessments - Sulfuric acid, barium salt (1:1): Human health tier I assessment
Fire Hazards
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:
Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.
Hazards Summary
TLV Basis: Pneumoconiosis; Therefore, because barium sulfate is a relatively low toxicity particle, but high levels of particles can cause inflammation or a benign pneumoconiosis, a TLV-TWA of 5 mg/m3 or inhalable particulate matter containing no asbestos and < 1% crystalline silica is recommended. [ACGIH] See the disease Pneumoconioses, benign.
RCRA Requirements
D005; A solid waste containing barium may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste. /Barium/
FIFRA Requirements
Residues of barium sulfate are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only. Use: carrier.
Residues of barium sulfate are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to animals. Use: carrier, density control agent.
Sicherheit und Schutzausrüstung
Fire Fighting
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:
In case of fire in the surroundings, use appropriate extinguishing media.
First Aid Measures
Fresh air, rest.
Remove contaminated clothes. Rinse skin with plenty of water or shower.
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Rinse mouth.
First Aid
Excerpt from NIOSH Pocket Guide for Barium sulfate:
(General first aid procedures)
Exposure Control and Personal Protection
TIH (Toxic Inhalation Hazard) - Term used to describe gases and volatile liquids that are toxic when inhaled. Some are TIH materials themselves, e.g., chlorine, and some release TIH gases when spilled in water, e.g., chlorosilanes. [ERG 2016].
4.0 [mg/m3] (inhalable fraction), 0.3 mg/m3 (respirable fraction)[German Research Foundation (DFG)]
Fire Fighting Procedures
Use dry chemical, carbon dioxide, water spray, or alcohol foam extinguishers ... If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors or shows any signs of deforming), withdraw immediately to a secure position ... The only respirators recommended for fire fighting are self-contained breathing apparatuses that have full facepieces and are operated in a pressure-demand or other positive-pressure mode.
If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide. Keep run-off water out of sewers and water sources. /Barium compounds, NOS/
Wear positive pressure self-contained breathing apparatus. /Barium compounds NOS/
Storage Conditions
Store at 25 °C (77 °F); excursions permitted to 15 to 30 °C (59 to 86 °F)
Store in tightly closed containers in a cool, well ventilated area away from incompatible materials ... A regulated, marked area should be established where this chemical is handled, used, or stored ...
Cleanup Methods
Spill handling: evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. Ventilate area of spill or lead after clean-up is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations.
The sulfate may be brushed up and treated as normal refuse. Soluble barium salts should be scooped up and treated as for waste disposal. Wash the spill area thoroughly with water.
Environmental considerations - land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water. Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents. /Barium/
Environmental considerations - water spill: Use natural barriers or oil spill control booms to limit spill travel. Use natural deep water pockets, excavated lagoons, or sand bag barriers to trap material at bottom. Remove trapped material with suction hoses. /Barium/
Environmental considerations - air spill: Apply water spray or mist to knock down vapors. /Barium/
Disposal Methods
Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D005, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.
Barite (barium sulfate) may be recovered from drilling muds for re-use as an alternative to disposal.
... Ion exchange, lime softening and reverse osmosis are effective to remove barium from drinking water. Conventional coagulation/filtration processes are not effective to remove barium from drinking water. /Barium ion/
Package lots. Place in a separate labeled container for recycling or disposal. Small quantities. Wear nitrile rubber gloves, laboratory coat, and eye protection. Avoid breathing dust. Dissolve the barium salt in the minimum volume of water. For each gram of barium salt, add 15 mL of 10% sodium sulfate solution. Let stand for 1 week. Test for completeness of precipitation by adding a few drops of 10% sodium sulfate solution. If required, add more sodium sulfate solution until no further precipitation occurs. Decant supernatant liquid or filter solid. Treat solid as normal refuse. Wash liquid into drain. /Barium salt/
Preventive Measures
Wear protective gloves and clothing to prevent any possibility of skin contact ... Wear dust-proof chemical goggles and face shield unless full facepiece respiratory protection is worn.
... Efforts should ... be made to reduce atmospheric concentration of barite dust to a minimum. /Barite dust/
SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.
SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.
For more Preventive Measures (Complete) data for Barium sulfate (8 total), please visit the HSDB record page.
Toxikologische Informationen
Health Effects
The health effects of the different barium compounds depend on how well the compound dissolves in water or the stomach contents. At low doses, barium acts as a muscle stimulant, while higher doses affect the nervous system, causing cardiac irregularities, tremors, weakness, anxiety, dyspnea, paralysisand possibly death. Barium may also cause gastrointestinal disturbances, damage the kidneys and cause decreases in body weight. (L214)
Ecotoxicity Values
EC50; Species: Daphnia magna (Water Flea); Conditions: freshwater, static, 11.5-14.5 °C, pH 7.2-7.8, dissolved oxygen 5.2-6.5 mg/L; Concentration: 52820 ug/L (43200-68140 ug/L) for 24 hr; Effect: intoxicaiton, immobilization
EC50; Species: Daphnia magna (Water Flea); Conditions: freshwater, static, 11.5-14.5 °C, pH 7.2-7.8, dissolved oxygen 5.2-6.5 mg/L; Concentration: 32000 ug/L for 48 hr; Effect: intoxicaiton, immobilization
Exposure Routes
The substance can be absorbed into the body by inhalation of its aerosol.
inhalation, skin and/or eye contact
Oral (L214) ; inhalation (L214)
Toxicity Summary
The CIR Expert Panel concluded that barium sulfate is safe in the present practices of use and concentration in cosmetics, when formulated to be non-irritating.
Safe for use in cosmetics, with qualifications
IDENTIFICATION: In nature barium occurs in a combined state, the principal forms being barite (barium sulfate) and witherite (barium carbonate). Barium sulfate has a very low water solubility. Barite ore is the raw material from which nearly all other barium compounds are derived. Barium and its compounds are used in diverse industrial products ranging from ceramics to lubricants. It is used in the manufacture of alloys, as a loader for paper, soap, rubber and linoleum, in the manufacture of valves and as an extinguisher for radium, uranium and plutonium fires. Anthropogenic sources of barium are primarily industrial. Emissions may result from mining, refining or processing barium minerals and the manufacture of barium products. Mining and processing of barite ore releases particulates into the air and from fugitive dusts from the use of barite in oil drilling and oil related industries. HUMAN EXPOSURE: It is difficult to assess the uptake of ingested barium because of a number of factors affect absorption. The presence of sulfate in food results in the precipitation of barium sulfate. ANIMAL/PLANT STUDIES: Insoluble barium compounds such as barium sulfate, accumulate in the lungs and are cleared slowly ciliary action.
Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis. Some of these barium's effects may also be due to barium induced neuromuscular blockade and membrane depolarization. (L214)
Ecotoxicity Excerpts
/AQUATIC SPECIES/ Barite affected the composition of estuarine communities developed from planktonic larvae in aquaria containing sand and flowing estuarine water. A significant number of annelids & mollusks decreased; however, clam growth, laevicardium mortoni, was not affected. Large amt of barium sulfate could adversely affect colonization of benthic animals. /Barite/
Signs and Symptoms
irritation eyes, nose, upper respiratory system; benign pneumoconiosis (baritosis)
Ingesting excess barium may cause vomiting, abdominal cramps, diarrhea, difficulties in breathing, increased or decreased blood pressure, numbness around the face, and muscle weakness. High levels may result in changes in heart rhythm or paralysis and possibly death. (L214)
Medical Surveillance
Persons manifesting resp disorders should be /protected from exposure/.
Workers who are to be exposed to the inhalation of barite dust should be subject to a preemployment exam.
Natural Pollution Sources
Large deposits of barite are found in China, Germany, India, Morocco, and in the U.S.
Occurs in nature as the mineral barite; also as barytes, heavy spar.
Barium is a naturally occurring element found in the earth's crust(1) that enters the environment through the weathering of rocks and minerals(SRC). The principal barium minerals are barite (barium sulfate) and witherite (barium carbonate)(1).
Barite, natural barium sulfate, occurs in the USA in Alaska, Arkansas ... Georgia, Missouri, Nevada, and Tennessee ... and was produced at 38 mines in the seven states in 1973, with Nevada supplying 50% of the tonnage. Missouri ranked second.
Most commercial sources of barite are replacement deposits in limestone, dolomitic sandstone and shales, or residual deposits caused by differential weathering that result in lumps of barite enclosed in clay. Barite sometimes occurs in veins and as a gangue mineral in metallic ores, such as lead, zinc, and silver, and is frequently associated with fluorspar. /Barite/
Human Toxicity Excerpts
/HUMAN EXPOSURE STUDIES/ Following a successful claim for damages by a speech pathologist, who was diagnosed with thyroid cancer after a period of employment including involvement in modified barium swallow procedures, a detailed study on occupational dose was commissioned. In this study radiation doses were measured routinely over 8 clinical periods using TLD100H dosimeters for staff involved with modified barium swallow radiological studies at three hospitals. The regions monitored included the unshielded thyroid, waist under apron, and axilla. Average unshielded thyroid doses for the speech pathologists were measured as 0.017, 0.003, and nil mGy per procedure over the hospitals surveyed, with dose measurements also found for the unshielded thyroid of the radiologist and nurse. This compares to thyroid doses of 0.200 and 0.055 mGy per procedure typically for cardiologists and orthopedic surgeons involved in radiological work, respectively. The use of a thyroid collar will substantially reduce this dose by a factor of about 40. While the worst-case doses are very small, attention should be given to education for staff involved in radiological procedures as well as ensuring that sound procedure protocols are in place and used.
/SIGNS AND SYMPTOMS/ Short Term Exposure: Irritates eyes and respiratory tract. Exposure to either form can affect the nervous system and cause hypokalemia, which can cause heart disorders. Long Term Exposure: Lungs may be affected by repeated or prolonged exposure to dust particles, resulting in baritosis (a form of benign pneumoconiosis). Animal studies have found increased blood pressure and changes in the heart from ingesting barium over a long time.
/SIGNS AND SYMPTOMS/ Inhalation of barium sulfate dust causes a benign pneumoconiosis ("baritosis") with conspicuous radiographic manifestations but no impairment of pulmonary function.
/SIGNS AND SYMPTOMS/ Several case reports and a prospective study ... have reported baritosis in barium exposed workers. Baritosis is considered a benign pneumoconiosis resulting from the inhalation of barite ore or barium sulfate. The most outstanding feature of baritosis is the intense radiopacity of the discrete opacities that are usually profusely disseminated throughout the lung fields; in some cases the opacities may be so numerous that they appear confluent. The Third Conference of Experts on Pneumoconiosis ... noted that barium sulfate produced a noncollagenous type of pneumoconiosis in which there is a minimal stromal reaction that consists mainly of reticulin fibers, intact alveolar architecture, and potentially reversible lesions. The available human data on baritosis suggest that the accumulation of barium in the lungs does not result in medical disability or symptomatology. /Barite ore/
For more Human Toxicity Excerpts (Complete) data for Barium sulfate (19 total), please visit the HSDB record page.
Regulatorische Informationen
RCRA Requirements
D005; A solid waste containing barium may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste. /Barium/
FIFRA Requirements
Residues of barium sulfate are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops only. Use: carrier.
Residues of barium sulfate are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to animals. Use: carrier, density control agent.
CERCLA Reportable Quantities
Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). /Barium/
State Drinking Water Guidelines
(AZ) ARIZONA 1500 ug/L /Barium/
(ME) MAINE 1500 ug/L /Barium/
(MN) MINNESOTA 2000 ug/L /Barium/
Federal Drinking Water Standards
Maximum Contaminant Level: 2 mg/L /Barium/
Maximum Contaminant Level Goal: 2 mg/L /Barium/
EPA 2000 ug/L /Barium/
Chemie und Industrie
Pharmakologische Informationen
Mechanism of Action
Barium sulfate is a heavy metal with a high atomic number (Z=56) and a K shell binding energy (K-edge of 37.4 keV) very close to that of most diagnostic x-ray beams. Due to these characteristics, barium is an ideal medium for the absorption of x-rays. Barium sulfate is essentially not absorbed from the GI tract nor metabolized in the body. Barium sulfate is used to fill the gastrointestinal tract lumen or to coat the mucosal surface and is administered orally, rectally, or instilled into an enterostomy tube or catheter,. Barium sulfate enhances delineation of the GI tract. The barium suspension covers the mucosal surface of the GI tract, allowing its shape, distensibility, motion, integrity, continuity, location within the torso, relationship to other organs to be closely examined. Various abnormalities, such as benign or malignant tumors, ulcers, strictures, diverticula, inflammation or infection, altered motility, displacement and other pathology can thereby be identified,. At lower concentrations (higher dilution), barium enhances the conspicuity of the GI tract to differentiate the GI tract from various abdominal organs in computed tomography examinations (CT scans) of the abdomen. Improved delineation of the gastrointestinal tract lumen and mucosa may be reached by contrast provided by gas (by the addition of bicarbonate or gas-filled balloons) in addition to the barium. This is known as a _double-contrast procedure_. Osmotically active agents (for example, sorbitol) are also used to induce fluid accumulation and distension of the GI system to enhance visualization.
Biological Half-Life
... In rats barium sulfate disappeared from the injection site with a half-life of 26 days ...
In Syrian hamsters, barium sulfate was found to be cleared from the lungs with a biological half-life of 8-9 days ...
(131)BaSO4 was found to be cleared from the lungs, with a biological half-life time of 8-9 days, through absorption into the general circulation with subsequent urinary clearance.
Measurements of the clearance of tracer levels of (131)barium sulfate (estimated maximum initial burden of 90 ug or 0.09 mg/kg from a 30 to 90 minute exposure) from the respiratory tract of female beagle dogs (10 + or - 1 kg) were performed. The biological half-life was eight days.
/Barium/ sulfate ... /has a calculated/ half-life of 26 days /in rats/.
Metabolism/Metabolites
Barium sulfate is poorly water soluble and shows negligible levels of absorption from the gastrointestinal tract following both oral or rectal administration. In healthy subjects, orally administered barium sulfate is generally excreted within 24 hours. Rectally administered barium sulfate is eliminated with clearance of the enema.
The in vivo solubility in rats of barium chloride, barium carbonate, barium sulfate, and barium fused in clay /was studied/. The chloride and the carbonate disappeared rapidly from the injection site. The sulfate dissolved more slowly; a half-life of 26 days was calculated. The fused clay was largely retained, the half-life being calculated as 1390 days.
Barium compounds are absorbed via ingestion and inhalation, the extent of which depends on the individual compound. In the body, the majority of the barium is found in the bone, while small amounts exists in the muscle, adipose, skin, and connective tissue. Barium is not metabolized in the body, but it may be transported or incorporated into complexes or tissues. Barium is excreted in the urine and faeces. (L214)
FDA Pharmacological Classification
25BB7EKE2E
BARIUM SULFATE
Established Pharmacologic Class [EPC] - Radiographic Contrast Agent
Mechanisms of Action [MoA] - X-Ray Contrast Activity
Barium sulfate is a Radiographic Contrast Agent. The mechanism of action of barium sulfate is as a X-Ray Contrast Activity.
BARIUM SULFATE
MeSH Pharmacological Classification
Substances used to allow enhanced visualization of tissues.
Chemical or physical agents that protect the skin from sunburn and erythema by absorbing or blocking ultraviolet radiation.
Absorption, Distribution and Excretion
Barium sulfate is not absorbed following oral or rectal administration with a normal gastrointestinal tract. In patients with a normal GI tract, barium sulfate is normally excreted within 24 hr after oral ingestion. Post rectal administration of barium sulfate suspensions, the drug is generally excreted when the enema is released. Some barium may remain in the colon for several weeks, however, and eventually clears, especially in patients with impaired intestinal peristalsis. It is difficult to quantify the uptake of ingested barium because of a number of factors affect its absorption. The presence of sulfate in food can cause the precipitation of barium sulfate. The following is the approximate time to peak opacification of organs by barium sulfate in a healthy GI tract: Esophagus, stomach, and duodenum uptake of barium sulfate occurs almost immediately after oral administration. Small intestine uptake is dependent on gastric emptying rate and viscosity of the preparation; it may be delayed 15-90 minutes post ingestion. Small intestine (enteroclysis studies) uptake is immediate, following direct instillation. Colon and distal small intestine uptake are dependent on patient positioning. Hydrostatic pressure also determines the rate and degree of opacification.
Barium sulfate is excreted unchanged in the feces.
The rate of excretion of barium sulfate is dependent on the route of administration and the status of peristaltic activity and motility of the gastrointestinal tract.
/In female beagle dog,/ (131)barium sulfate was found to be cleared from lung, with a biological half-time of 8-9 days ... . This indicated some solubility ... In body fluids, possibly in colloidal form. ... Barium sulfate ... Clearance rate /depends/ on specific surface area of inhaled particles and was lower for heat treated than for untreated particles.
In an extensive study, temperature and pulse rate measurements were taken as an indication of an acute inflammatory response for 291 humans administered a single unstated dose of a 50% w/v barium sulfate suspension for bronchographic purposes. The method of administration was unstated, but the suspension was presumed to have been instilled into the trachea and then blown into the lungs. In 154 patients, there was radiological evidence of the presence of barium sulfate in the bronchial tree at the time of the last available X-ray (various time points ranging from < 1 week to > 1 year after administration); in 135 patients, on the other hand, there was no radiological evidence of residual barium sulfate in the lungs 1 year after bronchography. Forty-one of these patients exhibited complete elimination of the barium sulfate from the lungs within 1 week; it was stated that in some of these patients, this clearance occurred within 24 hr.
After inhalation exposure of rats to a BaSO4 aerosol at 40 mg/cu m, 5 hr daily for 2 months, lymphatic transport was slight. The skeletal concentration of Ba was 0.8-1.5 mg/g dry substance (10-100 times the pulmonary concentration). Skeletal uptake decreased somewhat with advancing age.
Verwendung und Herstellung
Uses
CIR ingredient: Barium Sulfate
Used in paper, paints, textiles, plastics, batteries, and x-ray contrast dye; [HSDB]
Battery Manufacturing [Category: Industry]
Manufacture of photographic papers, artificial ivory, cellophane; filler for rubber, linoleum, oil cloth, polymeric fibers and resins, paper, lithographic inks; as a water color pigment for colored paper, in wallpaper; as a size for modifying colors of other pigments, in heavy concrete for radiation shield.
Weighting mud in oil-drilling, paper coatings, paints, filler and delustrant for textiles, plastics and lithograph inks; base for lake colors, X-ray photography, opaque medium for gastrointestinal radiography; in battery plate expanders.
Pigment extender for oil & water based paints; pigment (as component of lithopone) in paint & fabrics, plaster; filler in cosmetics (eg, lipstick); hardening agent for cement.
U.S. Exports
(1986) 7.26X10+6 g (crude barite) /estimate/
(1998) 14,700 tons /Barite/
(1986) 6,000 tons; (1987) 8,000 tons; (1988) 1,000 tons
Barite: Salient Statistics for the United States [Table#5074]
U.S. Imports
(1977) 7.89X10+9 G
(1979) 7.04X10+9 G
(1986) 6.80X10+8 g (crude barite) /estimate/
(1998) 21,300 tons /Barite/
For more U.S. Imports (Complete) data for Barium sulfate (6 total), please visit the HSDB record page.
U.S. Production
2023: 55,000,000 - <70,000,000 lb
2023: 100,000,000 - <500,000,000 lb
(1986) 3.43X10+8 g /estimate/
(1987) 3,769 short tons
(1998) 476,000 tons
(1972) 96,000 tons
Consumption Patterns
Over 65% of barite produced was used as a weighting agent in oil and gas well drilling fluids (1985).
50% Decrease in demand for barite in 1986 ... due primarily to a severe downturn in oil and gas well drilling activity prompted by ... soft world oil prices.
(1998) 3,275,000 tons
(1986) 1,105,000 tons; (1987) 1,304,000 tons; (1988) 1,798,000 tons
For more Consumption Patterns (Complete) data for Barium sulfate (7 total), please visit the HSDB record page.
Industry Uses
Swelling agent
Not Known or Reasonably Ascertainable
Methods of Manufacturing
(a) By treating a soln of a barium salt with sodium sulfate (salt cake). (b) by-product in manufacture of hydrogen peroxide. (c) occurs in nature as the mineral barite ...
Medical grade barium sulfate may be made by the reaction of barium carbonate or barium chloride with sulfuric acid.
Blanc fixe is made by mixing aq soln of barium sulfide and sodium sulfate under controlled conditions in order to produce a precipitate of uniform particles of pigmentary fineness. /Precipitated barium sulfate/
Formulations/Preparations
Anatrast is a cherry flavored, ready-to-use barium sulfate USP suspension paste. The product contains 100% w/v (56% w/w) barium sulfate USP, sorbitol, suspending and dispersing agents, simethicone, flavoring, preservatives and water.
Baricon is a lemon-vanilla flavored, high density barium sulfate formulation. The product contains 98% w/w barium sulfate USP, sucrose, simethicone, suspending agents, sorbitol, flavoring, sodium citrate and saccharin sodium.
Baro-cat is a banana-pineapple flavored ready-to-use barium sulfate suspension. The contrast medium contains 1.5% w/w (w/v) barium sulfate USP, with sorbitol, simethicone, suspending agent, potassium sorbate, citric acid, flavoring, saccharin sodium and water.
Barobag is a complete 3 liter enema kit containing a barium sulfate formulation for aqueous suspension. The contrast medium contains approximately 97% w/w barium sulfate USP, suspending agents, dispersing agents, and simethicone.
For more Formulations/Preparations (Complete) data for Barium sulfate (22 total), please visit the HSDB record page.
Household Products
Information on 134 consumer products that contain Barium sulfate in the following categories is provided:
Information on 3 consumer products that contain Barite in the following categories is provided:
Use Classification
Plastics -> Pigments agents
Plastics -> Polymer Type -> Polyolefin-I; PUR; Polyolefin-II; PVC (soft); ABS; PVC (rigid); PET; PMMA; PA; PC; (E)PS
Cosmetics -> Cosmetic colorant; Opacifying
Zugehörige Reaktionen
Verknüpfte Notizen
Wird geladen…