HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Natriumthiosulfat
na2s2o3 · SODIUM THIOSULPHATE · Thiosulfate · SODIUM HYPOSULFITE · HYPO · Na2O3S2 · Sodium Thiosulfite · Sodium Thiosulfat
Identifikatoren & physikalische Daten
| CAS No. | 7772-98-7 |
|---|---|
| Summenformel | Na2O3S2 |
| Durchschnittliche Molmasse | 158,11 g/mol |
| Monoisotopische Masse | 157,90842442 g/mol |
| SMILES | O=S([O-])([O-])=S.[Na+].[Na+] |
| InChIKey | AKHNMLFCWUSKQB-UHFFFAOYSA-L |
| PubChem CID | 24477 |
| ChEMBL | CHEMBL2096650 |
| ChEBI | CHEBI:132112 |
| EC No. | 231-867-5 |
| DTXSID | DTXSID9042417 |
| Lokaler Name | Natriumthiosulfat |
Chemische & physikalische Eigenschaften
| Polarare Oberfläche (TPSA) | 104 |
|---|---|
| H-Brücken-Donoren | 0 |
| H-Brücken-Akzeptoren | 4 |
| Frei drehbare Bindungen | 0 |
| Schwere Atome | 7 |
| Formalladung | 0 |
| Komplexität | 82,6 |
| Stoffklassen | Other Classes -> Sulfur Compounds |
| Kosmetika | Reducing |
| LogP (Verteilungskoeffizient) | -4.35 (calculated) |
| Dichte | 1.6671.7 g/cm³1.01 g/mL at 25 °C |
| Color/Form | POWDERCOLORLESS MONOCLINIC CRYSTALS |
| Löslichkeit | PRACTICALLY INSOL IN ALCOHOL50 G SOL IN 100 CC WATER231 G @ 100 °CSolubility in water, g/100ml at 20 °C: 20.9Immiscible with alcohol.Soluble in water. Insoluble in alcohol. |
| Human Drugs | FDA approved drugs -> Active ingredientEMA approved medicines: Human medicineAntidotes and other substances used in poisonings > Specific |
| Animal Drugs | Pharmaceuticals -> UK Veterinary Medicines Directorate List |
| Decomposition | DANGEROUSWHEN HEATED TO DECOMP, THEY EMIT HIGHLY TOXIC FUMES OF /DISODIUM OXIDE AND SULFUR OXIDES/.300 °C |
| Schmelzpunkt | 48.5 °C48°C |
| Dampfdruck | Vapor pressure at 20 °C: negligible |
| Brechungsindex | INDEX OF REFRACTION: 1.489 ALPHA, 1.508 BETA, 1.536 GAMMAOPTIC SIGN + |
| Siedepunkt | 100°C |
| Lagerbedingungen | Store at +5°C to +30°C. |
| Aggregatzustand | Solid |
| Wichte | 1.667 |
| Farbe | White |
| pH | 6.0-8.5 (25℃, 50mg/mL in H2O) |
| Merck | 14,8694 |
| Stabilität | Stable. Incompatible with strong acids, strong oxidizing agents, iodine, mercury. |
| Kosmetik-Inhaltsstoffe Funktionen | REDUCING |
| InChI | 1S/2Na.H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/q2*+1/p-2 |
| InChIKey | AKHNMLFCWUSKQB-UHFFFAOYSA-L |
| SMILES | [Na+].[Na+].[O-]S([O-])(=O)=S |
| LogP (Verteilungskoeffizient) | -0.428 (est) |
| CAS Datenbank | 7772-98-7(CAS DataBase Reference) |
| EPA chemische Informationen | Sodium thiosulfate (7772-98-7) |
Sicherheit & Vorschriften
| GHS-Einstufung | Not ClassifiedAggregated GHS information provided per 2963 reports by companies from 8 notifications to the ECHA C&L Inventory. |
|---|---|
| Regulatorische Informationen | Chemical: Thiosulfuric acid (H2S2O3), disodium saltThiosulfuric acid (H2S2O3), sodium salt (1:2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Thiosulfuric acid (H2S2O3), sodium salt (1:2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 24-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/14321Sodium thiosulphate: Does not have an individual approval but may be used under an appropriate group standard |
| Weitere Sicherheitsinformationen | IMAP assessments - Thiosulfuric acid (H2S2O3), disodium salt: Environment tier I assessment |
| Brandgefahren | Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. Risk of explosion on contact with oxidizing agents. |
| Gefahrenübersicht | Potential combustible dust hazardDecomposes slowly in water with potential generation of toxic and flammable hydrogen sulfide and corrosive hydrogen sulfite and sulfuric acidVery soluble in waterExtremely low vapor pressureMay violently decomposes at 223 deg C[CHEMINFO] ADI = 0-0.7 mg/kg[JECFA] May be used in food up to 0.1%[Hawley] See Potassium thiosulfate. |
| FDA-Anforderungen | 121.101LIMITATIONS: GRAS, SEQUESTRANT IN SALT UP TO 0.1% |
| EPA Safer Chemical | Chemical: Sodium thiosulfate |
| Chemical Dangers | Decomposes on heating. This produces toxic fumes including sulfur oxides. Reacts violently with strong oxidants. |
| Hazard Classes and Categories | Not Classified |
| Explosive Limits and Potential | DRY TRITURATION WITH OXIDIZING AGENTS SUCH AS POTASSIUM CHLORATE, POTASSIUM PERMANGANATE, OR NITRATE MAY CAUSE EXPLOSION.WHEN SODIUM NITRITE & THIOSULFATE MIXT WAS HEATED TO EVAPORATE TO DRYNESS, VIOLENT EXPLOSION OCCURRED. |
| Brandbekämpfung | In case of fire in the surroundings, use appropriate extinguishing media. |
| Erste-Hilfe-Maßnahmen | Fresh air, rest.Rinse and then wash skin with water and soap.Rinse with plenty of water for several minutes (remove contact lenses if easily possible).Rinse mouth. |
| Sichere Lagerung | Separated from strong oxidants. |
| Verschüttetes entsorgen | Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. |
| Eye Prevention | Wear safety goggles. |
| Fire Prevention | NO contact with oxidizing agents. |
| Inhalation Risk | A nuisance-causing concentration of airborne particles can be reached quickly when dispersed. |
| Ingestion Prevention | Do not eat, drink, or smoke during work. |
| Inhalation Prevention | Avoid inhalation of dust. |
| Protective Action Criteria (PAC) | 5.8 [mg/m3]64 [mg/m3]380 [mg/m3] |
| Signs and Symptoms | Redness. |
| Human Toxicity Excerpts | REMARKABLY INERT IN VIVO, EXCEPT FOR OSMOTIC DISTURBANCES. ... ACTS AS OSMOTIC CATHARTIC. |
| Drug Induced Liver Injury | Drug Induced Liver Injury Rank (DILIrank 2.0)Sodium thiosulfatevNo-DILI-concernNo matchDOI:10.1016/j.drudis.2016.02.015 |
| F | 3 |
| Wassergefährdungsklasse (WGK) | 1 |
| TSCA-Inventar-Status | TSCA listed |
| Zollcode | 28323000 |
| RTECS-Nr. | XN6476000 |
| R-Sätze (R) | 36/37/38 |
| Toxizität | LD50 orally in Rabbit: > 5000 mg/kg |
| Gefahrensymbole | Xi |
| Sicherheitshinweise (S) | 24/25-23-36-26 |
| Lagerklasse | 11 - Combustible Solids |
| Gefahrstoffdaten | 7772-98-7(Hazardous Substances Data) |
Anwendungen & Verwendung
Verwenden
Sodium thiosulfate is a common analytical reagent used in iodometric titration to analyze chlorine, bromine, and sulfide. Other uses are in bleaching paper pulp, bleaching straw, ivory, and bones, for removing chlorine from solutions, silver extraction from its ores, a mordant in dyeing and printing textiles, and as an antidote to cyanide poisoning. Another major application is in photography, where it is used as a fixer to dissolve unchanged silver salts from exposed negatives. Sodium Thiosulfate is used primarily as a medicament against cyanide poisoning, able to convert cyanide into thiocyanate, a reaction which is catalyzed by the enzyme Rhodanese. Antioxidant.
Herstellung & Synthese
synthetische
Sodium thiosulfate is a common reducing agent. It reduces iodine to iodide anion forming sodium tetrathionate. This reaction is utilized in the so-called iodometric titration: 2S2O32ˉ + I2 → S4O62ˉ + 2IˉSodium thiosulfate reacts with chlorine to form sodium bisulfate and hydrochloric acid. This reaction removes chlorine from aqueous solutions:Na2S2O3 + 4Cl2 + 5H2O → 2NaHSO4 + 8HClSodium thiosulfate reacts with hydrochloric acid, decomposing to sulfur and sulfur dioxide: Na2S2O3 + 2HCl → 2NaCl + S + SO2 + H2O.