Chondroitin, 4-(Hydrogensulfat)
SODIUM CHONDROITIN SULFATE · CHONDROITIN-4-SULFATE · CHONDROITIN SULFATE A · turkadon · Chodroitin Sulfate · chondroitinasulfate · Chondroitine sulfate · ChondroitinSulphateA
Identifikatoren & physikalische Daten
| CAS No. | 24967-93-9 |
|---|---|
| Summenformel | C13H21NO15S |
| Durchschnittliche Molmasse | 463,37 g/mol |
| Monoisotopische Masse | 463,06318997 g/mol |
| SMILES | CC(=O)N[C@@H]1[C@@H](O[C@@H]2O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@@H](OS(=O)(=O)O)O[C@H]1O |
| InChIKey | KXKPYJOVDUMHGS-OSRGNVMNSA-N |
| PubChem CID | 24766 |
| ChEMBL | CHEMBL2303614 |
| EC No. | 232-696-9 |
| DTXSID | DTXSID601017238 |
| Lokaler Name | Chondroitin, 4-(Hydrogensulfat) |
Chemische & physikalische Eigenschaften
| XLogP | -4,8 |
|---|---|
| Polarare Oberfläche (TPSA) | 267 |
| H-Brücken-Donoren | 8 |
| H-Brücken-Akzeptoren | 15 |
| Frei drehbare Bindungen | 6 |
| Schwere Atome | 30 |
| Formalladung | 0 |
| Komplexität | 739 |
| Kosmetika | AntistaticHair conditioning |
| Löslichkeit | SolubleH2O: 0.1 g/mL, slightly hazy, faintly yellow |
| Schmelzpunkt | 190-194ºC |
| Dissociation Constants | 1.5-2 |
| Lagerbedingungen | 2-8°C |
Sicherheit & Vorschriften
| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 63.6% (7 of 11) of all reports.DangerH317 (36.4%): May cause an allergic skin reaction [Warning Sensitization, Skin]P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P317, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 11 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Regulatorische Informationen | Chemical: Chondroitin, hydrogen sulfateXU - indicates a substance exempt from reporting under the Chemical Data Reporting Rule, (40 CFR 711).Chondroitin, hydrogen sulfate, sodium salt: Does not have an individual approval but may be used under an appropriate group standardChondroitin hydrogen sulfate: Does not have an individual approval but may be used under an appropriate group standard |
| Weitere Sicherheitsinformationen | IMAP assessments - Chondroitin, hydrogen sulfate: Environment tier I assessment |
| Hazard Classes and Categories | Skin Sens. 1 (36.4%) |
| F | 3-10 |
| Wassergefährdungsklasse (WGK) | 3 |
| Toxizität | mouse,LD,oral,> 15gm/kg (15000mg/kg),Zhonghua Yixue Zazhi. Chinese Medical Journal. Vol. 58, Pg. 739, 1978. |
Anwendungen & Verwendung
Beschreibung
Chondroitin 4-sulfate is a natural polymer of a disaccharide consisting of glucuronic acid and N-acetyl glucosamine which is sulfated either in the 4 or 6 position. It is a glycosaminoglycan considered as a symptomatic slow-acting drug for osteoarthritis (SYSADOA).
Verwenden
sodium chondroitin sulfate is described as a skin-conditioning agent, with possible anti-inflammatory properties. It can be found in such products as moisturizers and night skin care preparations. It is a derivative of natural mucopolysaccharides. Chondroitin 4-sulfate is an important structural component of cartilage and has been used as a dietary supplement to treat symptoms of joint discomfort.