10,16-Docosadienoic acid, 11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-, calcium salt (1:1), (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-
Grundinformationen
- CAS
56092-82-1- Standard-SMILES
C[C@H](CCC(=O)O)C[C@H](C)C[C@H](C)C(=O)/C=C(\O)[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@@](C)([C@H]2CC[C@@](C)([C@@H](C)O)O2)O1.[Ca]- InChIKey
MERVBOMMKAULKQ-WYGBAUISSA-N- Summenformel
- C41H72CaO9
- Durchschnittliche Molmasse
- 749,1 g/mol
- Monoisotopische Masse
- 748,4802247
Überblick
See also: ionomycin calcium salt (annotation moved to).
Namen und Bezeichner
- Bevorzugter Name
- 10,16-Docosadienoic acid, 11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-, calcium salt (1:1), (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-
- Englischer Name
- IONOMYCIN CALCIUM SALT
- Summenformel
- C41H70CaO9
- Molmasse
- 749.08
Namen und Synonyme
10,16-Docosadienoic acid, 11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-, calcium salt (1:1), (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-10,16-Docosadienoic acid, 11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-((2S,2'R,5S,5'S)-octahydro-5'-((1R)-1-hydroxyethyl)-2,5'-dimethyl(2,2'-bifuran)-5-yl)-9-oxo-, calcium salt (1:1), (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-RefChem:43694256092-82-1AKOS040733458ATCC 31005Ionomycin,IonIONOMYCIN (CA)SQ23377 calciumIONOMYCIN CA-SALTionomycin calciumCalcium ionomycin.
Weitere Namen anzeigen
Ionomycin Ca2+ saltIONOMYCIN CALCIUM SALTIONOMYCIN CALCIUM SALT 1MG
Eigenschaften
Berechnete Struktureigenschaften
- Polarare Oberfläche (TPSA)
- 154 Ų
- H-Brücken-Donoren
- 5
- H-Brücken-Akzeptoren
- 9
- Frei drehbare Bindungen
- 22
- Schwere Atome
- 51
- Formalladung
- 0
- Komplexität
- 1.120
Physikochemische Eigenschaften
- Schmelzpunkt
- 205 · 205-206 C
- Flammpunkt
- 87 °C · 87 °C
- storage temp.
- 20 °C · −20°C
- Löslichkeit
- Soluble in DMSO (10mg/ml). Also soluble in ethanol or methanol
- Aggregatzustand
- White to off-white solid
- Farbe
- white to off-white
- Biologische Quelle
- Streptomyces conglobatus
- BRN
- 1416163 · 1416163
- Stabilität
- 1 year · Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
- InChIKey
- WKRWUYKLUMMAKG-WYGBAUISSA-L
Sicherheit und Regulatorisches
Sicherheitsangaben dienen nur zur Orientierung und ersetzen weder das Sicherheitsdatenblatt (SDB) des Lieferanten noch geltende Vorschriften oder eine fachliche Bewertung.
Gefahrenhinweise
Regulatory Information
10,16-Docosadienoic acid, 11,19,21-trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-, calcium salt (1:1), (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-: Does not have an individual approval but may be used under an appropriate group standard
Sicherheitsdaten
- wgk
- 3
- hs_code
- 29419090
- RTECS-Nr.
- NO0650000
- risk_code
- 22
- hazard_code
- Xn
- safety_code
- 36
- hazard_class
- 3
- Speicherklasse
- 11 - Combustible Solids
- Hazard Classifications
- Acute Tox. 4 Oral
Chemie und Industrie
Anwendungen
BeschreibungIonomycin is a calcium ionophore originally isolated from S. conglobatus. It induces intracellular calcium mobilization in X. laevis oocytes when used at a concentration of 5 μM. Ionomycin (5 μM) induces the formation of neutrophil extracellular traps (NETs) in isolated human neutrophils. Ionomycin in combination with phorbol 12-myristate 13-acetate (PMA; ) has commonly been used to induce the proliferation and activation of T cells, as well as to stimulate cytokine production in macrophages, in vitro.
VerwendenIonomycin calcium salt is used as a polyether antibiotic and apoptotic degeneration inducer. Ionomycin induces apoptotic degeneration of embryonic cortical neurons and cell cycle arrest at G1 phase. It is more effective than A23187 (sc-3591) and provides a useful tool for increasing intracellular Ca2+ concentration.
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上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
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