| GHS-Einstufung | This chemical does not meet GHS hazard criteria for 0.5% (1 of 204) of reports.DangerH271 (73.5%): May cause fire or explosionstrong Oxidizer [Danger Oxidizing liquidsOxidizing solids]H272 (23.5%): May intensify fireoxidizer [Danger Oxidizing liquidsH290 (75.5%): May be corrosive to metals [Warning Corrosive to Metals]H302 (76%): Harmful if swallowed [Warning Acute toxicity, oral]H314 (98%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]H318 (75.5%): Causes serious eye damage [Danger Serious eye damage/eye irritation]H400 (75%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]H410 (76.5%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]P210, P220, P234, P260, P264, P264+P265, P270, P273, P280, P283, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P306+P360, P316, P317, P321, P330, P363, P370+P378, P371+P380+P375, P390, P391, P405, P406, P420, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 204 reports by companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Reported as not meeting GHS hazard criteria per 1 of 204 reports by companies.There are 14 notifications provided by 203 of 204 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
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| Regulatorische Informationen | Nitric acid, palladium(2+) salt (2:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Nitric acid, palladium(2+) salt (2:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 13-01-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/19319Palladium nitrate: Does not have an individual approval but may be used under an appropriate group standard |
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| Gefahrenübersicht | An eye irritant[eChemPortal: ERMA] May cause irritation[MSDSonline] See NITRATES and NITRITES. |
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| Hazard Classes and Categories | Ox. Sol. 1 (73.5%)Ox. Sol. 2 (23.5%)Met. Corr. 1 (75.5%)Acute Tox. 4 (76%)Skin Corr. 1B (98%)Eye Dam. 1 (75.5%)Aquatic Acute 1 (75%)Aquatic Chronic 1 (76.5%) |
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| Protective Action Criteria (PAC) | 7.9 [mg/m3]87 [mg/m3]520 [mg/m3] |
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| Treatment | Methemoglobinemia can be treated with supplemental oxygen and methylene blue 1% solution administered intravenously slowly over five minutes followed by IV flush with normal saline. Methylene blue restores the iron in hemoglobin to its normal (reduced) oxygen-carrying state. (L1613) |
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| Gesundheitliche Auswirkungen | Contact with palladium may cause palladium sensitivity and allergy. Animal studies have shown that palladium may damage the liver and kidney. Nitrate and nitrite poisoning causes methemoglobinemia. Nitrites may cause pregnancy complications and developmental effects. They may also be carcinogenic. (L1137, L798) |
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| Expositionspfade | Oral (L1137)inhalation (L1137) |
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| Toxizitätsübersicht | Due to their ability to form strong complexes with both inorganic and organic ligands, palladium ions can disturb cellular equilibria, replace other essential ions, and interact with functional groups of macromolecules, such as proteins or DNA. Palladium complexes binding to DNA and RNA leads to strand breakage. Palladium ions are able to inhibit most major cellular functions, including DNA and RNA synthesis. Palladium compounds have been shown to bind to and inhibit various enzymes, including creatine kinase and prolyl hydroxylase. Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613, L798) |
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| Signs and Symptoms | Skin contact with palladium may cause contact dermatitis, erythema, and oedema. Nitrate and nitrite poisoning causes methemoglobinemia. Symptoms include cyanosis, cardiac dysrhythmias and circulatory failure, and progressive central nervous system (CNS) effects. CNS effects can range from mild dizziness and lethargy to coma and convulsions. (L1137, L798) |
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| Carcinogen Classification | Ingested nitrate or nitrite under conditions that result in endogenous nitrosation is probably carcinogenic to humans (Group 2A). (L135) |
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